CP-94253

CP-94253
Identifiers
	IUPAC name 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine;
CAS Number	131084-35-0 ;
PubChem CID	4029677;
IUPHAR/BPS	3221;
ChemSpider	3246572 ;
Chemical and physical data
Formula	C15H19N3O
Molar mass	257.337 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES c13nc(OCCC)ccc1[nH]cc3C2=CCNCC2;
	InChI InChI=1S/C15H19N3O/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11/h3-5,10,16-17H,2,6-9H2,1H3 ; Key:KWQWBZIGHIOKIO-UHFFFAOYSA-N ;
	(what is this?) (verify)

Short description: Potent and selective serotonin 5-HT1B receptor agonist

CP-94253 is a drug which acts as a potent and selective serotonin 5-HT_1B receptor agonist, with approximately 25× and 40× selectivity over the closely related 5-HT_1D and 5-HT_1A receptors.^[1] It has a range of behavioral effects, based on animal testing. The effects include the following: promoting wakefulness by increasing dopamine release in the brain;^[2]^[3] reducing food intake and promoting satiety;^[4]^[5]^[6] enhancing the reinforcing effects of cocaine;^[7]^[8]^[9]^[10] and possible antidepressant effects.^[11] A recent study^[12] found that "Regardless of sex, CP94253 decreased cocaine intake after abstinence and during resumption of SA [self-administration] and decreased cue reactivity" suggesting that agonism of the inhibitory 5-HT2B receptors may diminish the cognitive reward of cocaine usage and increased use of the drug without a period of abstinence may be a product of test subjects trying to achieve a previously rewarding experience through larger dosages of cocaine.

References

↑ "Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253". Drug Development Research 26 (3): 241–250. 1992. doi:10.1002/ddr.430260305.
↑ "Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat". Neuropharmacology 34 (12): 1647–1651. December 1995. doi:10.1016/0028-3908(95)00112-3. PMID 8788962.
↑ "Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization". The Journal of Pharmacology and Experimental Therapeutics 277 (1): 40–47. April 1996. PMID 8613947.
↑ "The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence". Physiology & Behavior 60 (3): 933–939. September 1996. doi:10.1016/0031-9384(96)00073-x. PMID 8873272.
↑ "CP-94, 253: a selective serotonin1B (5-HT1B) agonist that promotes satiety". Psychopharmacology 131 (3): 264–270. June 1997. doi:10.1007/s002130050292. PMID 9203237.
↑ "5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253". Psychopharmacology 164 (1): 49–60. October 2002. doi:10.1007/s00213-002-1162-7. PMID 12373419.
↑ "Serotonin1B receptor stimulation enhances cocaine reinforcement". The Journal of Neuroscience 18 (23): 10078–10089. December 1998. doi:10.1523/JNEUROSCI.18-23-10078.1998. PMID 9822762.
↑ "Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats". Behavioural Pharmacology 12 (2): 109–116. April 2001. doi:10.1097/00008877-200104000-00004. PMID 11396515.
↑ "Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats". European Journal of Pharmacology 559 (2–3): 165–172. March 2007. doi:10.1016/j.ejphar.2006.12.012. PMID 17291490.
↑ "Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats". Pharmacological Reports 60 (6): 798–810. 2008. PMID 19211971.
↑ "Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action". European Journal of Pharmacology 516 (1): 46–50. May 2005. doi:10.1016/j.ejphar.2005.04.025. PMID 15913599.
↑ "5-HT_1B receptor agonist attenuates cocaine self-administration after protracted abstinence and relapse in rats". Journal of Psychopharmacology 35 (10): 1216–1225. October 2021. doi:10.1177/02698811211019279. PMID 34049460.

0.00

(0 votes)

Original source: https://en.wikipedia.org/wiki/CP-94253. Read more

[1] "Biochemical and behavioral studies of the 5-HT1B receptor agonist, CP-94,253". Drug Development Research 26 (3): 241–250. 1992. doi:10.1002/ddr.430260305.

[2] "Effects of selective activation of the 5-HT1B receptor with CP-94,253 on sleep and wakefulness in the rat". Neuropharmacology 34 (12): 1647–1651. December 1995. doi:10.1016/0028-3908(95)00112-3. PMID 8788962.

[3] "Serotonin-mediated increase in prefrontal cortex dopamine release: pharmacological characterization". The Journal of Pharmacology and Experimental Therapeutics 277 (1): 40–47. April 1996. PMID 8613947.

[4] "The 5-HT1B receptor agonist CP-94,253 reduces food intake and preserves the behavioural satiety sequence". Physiology & Behavior 60 (3): 933–939. September 1996. doi:10.1016/0031-9384(96)00073-x. PMID 8873272.

[5] "CP-94, 253: a selective serotonin1B (5-HT1B) agonist that promotes satiety". Psychopharmacology 131 (3): 264–270. June 1997. doi:10.1007/s002130050292. PMID 9203237.

[6] "5-HT1B receptors modulate components of satiety in the rat: behavioural and pharmacological analyses of the selective serotonin1B agonist CP-94,253". Psychopharmacology 164 (1): 49–60. October 2002. doi:10.1007/s00213-002-1162-7. PMID 12373419.

[7] "Serotonin1B receptor stimulation enhances cocaine reinforcement". The Journal of Neuroscience 18 (23): 10078–10089. December 1998. doi:10.1523/JNEUROSCI.18-23-10078.1998. PMID 9822762.

[8] "Effect of serotonin (5-HT)1B receptor ligands on cocaine sensitization in rats". Behavioural Pharmacology 12 (2): 109–116. April 2001. doi:10.1097/00008877-200104000-00004. PMID 11396515.

[pmid17291490-9] "Effects of serotonin 5-HT1B receptor ligands on the cocaine- and food-maintained self-administration in rats". European Journal of Pharmacology 559 (2–3): 165–172. March 2007. doi:10.1016/j.ejphar.2006.12.012. PMID 17291490.

[pmid19211971-10] "Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats". Pharmacological Reports 60 (6): 798–810. 2008. PMID 19211971.

[11] "Antidepressant-like effect of the selective 5-HT1B receptor agonist CP 94253: a possible mechanism of action". European Journal of Pharmacology 516 (1): 46–50. May 2005. doi:10.1016/j.ejphar.2005.04.025. PMID 15913599.

[12] "5-HT_1B receptor agonist attenuates cocaine self-administration after protracted abstinence and relapse in rats". Journal of Psychopharmacology 35 (10): 1216–1225. October 2021. doi:10.1177/02698811211019279. PMID 34049460.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

[12]

Identifiers

IUPAC name 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine
CAS Number	131084-35-0^Y
PubChem CID	4029677
IUPHAR/BPS	3221
ChemSpider	3246572^N
Chemical and physical data
Formula	C₁₅H₁₉N₃O
Molar mass	257.337 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES c13nc(OCCC)ccc1[nH]cc3C2=CCNCC2
InChI InChI=1S/C15H19N3O/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11/h3-5,10,16-17H,2,6-9H2,1H3^N Key:KWQWBZIGHIOKIO-UHFFFAOYSA-N^N
^NY (what is this?) (verify)

CP-94253

Topic: Chemistry

References