Chitosan diacetate

Chitosan diacetate (CDA) is a chemical derivative of chitosan that can be synthesized by reaction with iodoacetic acid,. This polymer can be crosslinked with zinc chloride (ZnCl₂), aluminum chloride (AlCl₃), or calcium chloride (CaCl₂), and the resulting matrices can be loaded with any drug. This crosslinking of chitosan diacetate matrices can modulate the drug release properties.^[1]^[2]

References

↑ AlKhatib, Hatim S.; Aiedeh, Khaled M.; Bustanji, Yasser; Hamed, Saja; Mohammad, M.K.; AlKhalidi, Bashar; Najjar, Samer (November 2008). "Modulation of buspirone HCl release from hypromellose matrices using chitosan succinate: Implications for pH-independent release". European Journal of Pharmaceutics and Biopharmaceutics 70 (3): 804–812. doi:10.1016/j.ejpb.2008.06.017.
↑ Aiedeh, Khaled M.; Taha, Mutasem O.; Al-Hiari, Yusuf; Bustanji, Yasser; AlKhatib, Hatim S. (January 2007). "Effect of Ionic Crosslinking on the Drug Release Properties ofChitosan Diacetate Matrices". Journal of Pharmaceutical Sciences 96 (1): 38–43. doi:10.1002/jps.20764.

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[AlKhatib-1] AlKhatib, Hatim S.; Aiedeh, Khaled M.; Bustanji, Yasser; Hamed, Saja; Mohammad, M.K.; AlKhalidi, Bashar; Najjar, Samer (November 2008). "Modulation of buspirone HCl release from hypromellose matrices using chitosan succinate: Implications for pH-independent release". European Journal of Pharmaceutics and Biopharmaceutics 70 (3): 804–812. doi:10.1016/j.ejpb.2008.06.017.

[2] Aiedeh, Khaled M.; Taha, Mutasem O.; Al-Hiari, Yusuf; Bustanji, Yasser; AlKhatib, Hatim S. (January 2007). "Effect of Ionic Crosslinking on the Drug Release Properties ofChitosan Diacetate Matrices". Journal of Pharmaceutical Sciences 96 (1): 38–43. doi:10.1002/jps.20764.

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Chitosan diacetate

Topic: Chemistry

References