Categories
Cod-THC
Topic: Chemistry
From HandWiki - Reading time: 5 min
Cod-THC (Codeine Δ9-tetrahydrocannabinol carbonate) is a synthetic codrug formed by linking tetrahydrocannabinol with codeine via a carbonate bridge. It is well absorbed orally and shows superior analgesic effects in animal studies compared to a simple mixture of the two drugs.[1][2][3]
THC can partially inhibit CYP2D6, which is the enzyme that transforms codeine into its active metabolite morphine.[4][5] It's not well understood how THC may impact codeines metabolism in humans.
See also
- Benorilate
- Codeine-6-glucuronide
- Fenethylline
- THC-methylcarbonate
- THC-O-acetate
- THC-VHS
References
- ↑ ""Breaking bud": the effect of direct chemical modifications of phytocannabinoids on their bioavailability, physiological effects, and therapeutic potential". Organic & Biomolecular Chemistry 21 (18): 3715–3732. May 2023. doi:10.1039/d3ob00068k. PMID 36825573.
- ↑ Holtman JR, Crooks PA, Dhooper HK, "Novel synergistic opioid-cannabinoid codrug for pain management", US patent 2008176885A1, published 24 July 2008, assigned to University of Kentuckyand Insys Therapeutics Inc
- ↑ "Improving the Use of Drug Combinations Through the Codrug Approach". Prodrugs and Targeted Delivery. Methods and Principles in Medicinal Chemistry. 47. 2010. pp. 345–383. doi:10.1002/9783527633166.ch13. ISBN 978-3-527-32603-7.
- ↑ "Cannabinoid Metabolites as Inhibitors of Major Hepatic CYP450 Enzymes, with Implications for Cannabis-Drug Interactions". Drug Metabolism and Disposition 49 (12): 1070–1080. December 2021. doi:10.1124/dmd.121.000442. PMID 34493602.
- ↑ "Differential Interactions of Selected Phytocannabinoids with Human CYP2D6 Polymorphisms". Biochemistry 60 (37): 2749–2760. September 2021. doi:10.1021/acs.biochem.1c00158. PMID 34491040.
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