Copper ibuprofenate

Copper ibuprofenate
Names
	IUPAC name bis[2-(4-isobutylphenyl)propionato]copper(II)
Identifiers
CAS Number	66840-44-6 ;
3D model (JSmol)	Interactive image;
	InChI InChI=1S/4C13H17O2.2Cu/c41-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15;;/h44-7,9-10H,8H2,1-3H3;;/q4-3;2+6 Key: HEFOJHHJEKPEDO-UHFFFAOYSA-N;
	SMILES c0cc(CC(C)C)ccc0C(C)[C-](O[Cu+2]123)O[Cu+2](O[C-](O1)C(C)c0ccc(CC(C)C)cc0)(O[C-](O2)C(C)c0ccc(CC(C)C)cc0)O[C-](O3)C(C)c0ccc(CC(C)C)cc0;
Properties
Chemical formula	C52H68Cu2O8
Molar mass	948.200 g·mol−1
Appearance	Green powder
Solubility in water	Slightly soluble
Solubility in isopropanol	Slightly soluble
Related compounds
Related compounds	Copper aspirinate Ibuprofen
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Copper ibuprofenate is a chemical complex consisting of copper(II) and the chelate form of the anti-inflammatory drug ibuprofen.^[1]^[2] The compound is prepared by the reaction of sodium ibuprofenate with copper(II) sulfate.

It has been suggested that copper complexes of anti-inflammatory drugs are more active than the parent drug^[3] and produce fewer gastrointestinal side-effects.^[4] In 2008, a United States patent was issued for the utilization of ibuprofenate complexes (including copper ibuprofenate) as a wood preservative.^[5]

References

↑ Frazier, D. R.; S. K. Lynch; G. O. Carlisle (1981). "Synthesis and magnetic properties of bis[2-(4-isobutylphenyl)propionato]copper(II)". Journal of Inorganic and Nuclear Chemistry 43 (11): 2747–2748. doi:10.1016/0022-1902(81)80610-0.
↑ Abuhijleh AL (September 1994). "Mononuclear and binuclear copper(II) complexes of the antiinflammatory drug ibuprofen: synthesis, characterization, and catecholase-mimetic activity". J. Inorg. Biochem. 55 (4): 255–62. doi:10.1016/0162-0134(94)85010-0. PMID 7964714.
↑ Sorenson JR (1989). "Copper complexes offer a physiological approach to treatment of chronic diseases". Prog Med Chem. Progress in Medicinal Chemistry 26: 437–568. doi:10.1016/s0079-6468(08)70246-7. ISBN 9780444810380. PMID 2690187.
↑ "Immobilization of ibuprofen and copper-ibuprofen drugs on layered double hydroxides". J Pharm Sci 94 (5): 1135–48. May 2005. doi:10.1002/jps.20336. PMID 15793807.
↑ US patent 7462227, Anderson, Albert Gordon; Feaster, John; Patel, Damini; Scialdone, Mark, "Ibuprofen complexes as wood preservatives", issued 2007-07-26

Copper ibuprofenate

Topic: Chemistry

References

Further reading