Categories
Cortifen
Topic: Chemistry
From HandWiki - Reading time: 4 min
Short description: Chemical compound
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| Other names | Cortiphen; Kortifen; Fencoron; 11-Deoxycortisol 21-(4-(bis(2-chloroethyl)amino)phenyl)acetate; 11-Desoxy-17α-hydroxy-21-[n-di-2(chlorethyl)aminophenyl acetate]corticosterone |
| Drug class | Cytostatic antineoplastic agent; Corticosteroid; Glucocorticoid |
| Identifiers | |
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| PubChem CID | |
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| Chemical and physical data | |
| Formula | C33H43Cl2NO5 |
| Molar mass | 604.61 g·mol−1 |
| 3D model (JSmol) | |
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Cortifen, also known as cortiphen or kortifen, as well as fencoron, is a synthetic glucocorticoid corticosteroid and cytostatic antineoplastic agent which was developed in Russia for potential treatment of tumors.[1][2][3] It is a hydrophobic chlorphenacyl nitrogen mustard ester of 11-deoxycortisol (cortodoxone).[1][2][3][4]
See also
References
- ↑ 1.0 1.1 "[Experimental study of the antitumor properties and mechanism of action of kortifen]" (in ru). Voprosy Onkologii 35 (4): 450–456. 1989. PMID 2728387.
- ↑ 2.0 2.1 "Biopharmaceutical investigation of a new medicinal form of the antitumor drug cortifen". Pharmaceutical Chemistry Journal 33 (10): 540–542. 1999. doi:10.1007/BF02508377. ISSN 0091-150X.
- ↑ 3.0 3.1 "Dependence of antitumor effect of hormonal cytostatic cortifen on expression of glucocorticoid receptors in brain tumor cells". Bulletin of Experimental Biology and Medicine 127 (3): 299–300. 1999. doi:10.1007/BF02433363. ISSN 0007-4888.
- ↑ "[Pharmacological aspects in the development of liposomal medicinal preparations for the internal injection of hydrophobic cytostatics]" (in ru). Vestnik Rossiiskoi Akademii Meditsinskikh Nauk (1): 42–45. 2002. PMID 11882971.
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