Cytidine

Cytidine
Names
	IUPAC name Cytidine
	Systematic IUPAC name 4-Amino-1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2(1H)-one
	Other names 4-Amino-1-β-D-ribofuranosyl-2(1H)-pyrimidinone; 4-Amino-1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2-one
Identifiers
CAS Number	65-46-3 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:17562 ;
ChEMBL	ChEMBL95606 ;
ChemSpider	5940 ;
IUPHAR/BPS	4728;
KEGG	D07769 ;
MeSH	Cytidine
PubChem CID	6175;
UNII	5CSZ8459RP ;
	InChI InChI=1S/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 Key: UHDGCWIWMRVCDJ-XVFCMESISA-N ; InChI=1/C9H13N3O5/c10-5-1-2-12(9(16)11-5)8-7(15)6(14)4(3-13)17-8/h1-2,4,6-8,13-15H,3H2,(H2,10,11,16)/t4-,6-,7-,8-/m1/s1 Key: UHDGCWIWMRVCDJ-XVFCMESIBD;
	SMILES O=C1/N=C(/N)\C=C/N1[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO;
Properties
Chemical formula	C9H13N3O5
Molar mass	243.217
Appearance	white, crystalline powder
Melting point	230 °C (decomposes)
Magnetic susceptibility (χ)	-123.7·10−6 cm3/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Cytidine (symbol C or Cyd) is a nucleoside molecule that is formed when cytosine is attached to a ribose ring (also known as a ribofuranose) via a β-N₁-glycosidic bond. Cytidine is a component of RNA. It is a white water-soluble solid.^[2] which is only slightly soluble in ethanol.^[1]

Dietary sources

Dietary sources of cytidine include foods with high RNA (ribonucleic acid) content,^[3] such as organ meats, brewer's yeast, as well as pyrimidine-rich foods such as beer. During digestion, RNA-rich foods are broken-down into ribosyl pyrimidines (cytidine and uridine), which are absorbed intact.^[3] In humans, dietary cytidine is converted into uridine,^[4] which is probably the compound behind cytidine's metabolic effects.

Cytidine analogues

A variety of cytidine analogues are known, some with potentially useful pharmacology. For example, KP-1461 is an anti-HIV agent that works as a viral mutagen,^[5] and zebularine exists in E. coli and is being examined for chemotherapy. Low doses of azacitidine and its analog decitabine have shown results against cancer through epigenetic demethylation.^[6]

Biological actions

In addition to its role as a pyrimidine component of RNA, cytidine has been found to control neuronal-glial glutamate cycling, with supplementation decreasing midfrontal/cerebral glutamate/glutamine levels.^[7] As such, cytidine has generated interest as a potential glutamatergic antidepressant drug.^[7]

Related compounds

Deoxycytidine is cytosine attached to a deoxyribose.

Properties

References

↑ ^1.0 ^1.1 ^1.2 William M. Haynes (2016). CRC Handbook of Chemistry and Physics (97th ed.). Boca Raton: CRC Press. pp. 3–140. ISBN 978-1-4987-5429-3. https://books.google.com/books?id=VVezDAAAQBAJ.
↑ ^2.0 ^2.1 Robert A. Lewis, Michael D. Larrañaga, Richard J. Lewis Sr. (2016). Hawley's Condensed Chemical Dictionary (16th ed.). Hoboken, New Jersey: John Wiley & Sons, Inc.. p. 688. ISBN 978-1-118-13515-0.
↑ ^3.0 ^3.1 Jonas DA; Elmadfa I; Engel KH et al. (2001). "Safety considerations of DNA in food". Ann Nutr Metab 45 (6): 235–54. doi:10.1159/000046734. PMID 11786646. http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=anm45235.
↑ "Effect of oral CDP-choline on plasma choline and uridine levels in humans". Biochem. Pharmacol. 60 (7): 989–92. Oct 2000. doi:10.1016/S0006-2952(00)00436-6. PMID 10974208.
↑ John S. James. "New Kind of Antiretroviral, KP-1461". AIDS Treatment News. http://www.aidsnews.org/2007/10/kp-1461.html.
↑ "Scientists reprogram cancer cells with low doses of epigenetic drugs". Medical XPress. March 22, 2012. http://medicalxpress.com/news/2012-03-scientists-reprogram-cancer-cells-doses.html.
↑ ^7.0 ^7.1 Machado-Vieira, Rodrigo; Salvadore, Giacomo; DiazGranados, Nancy; Ibrahim, Lobna; Latov, David; Wheeler-Castillo, Cristina; Baumann, Jacqueline; Henter, Ioline D. et al. (2010). "New Therapeutic Targets for Mood Disorders". The Scientific World Journal 10: 713–726. doi:10.1100/tsw.2010.65. ISSN 1537-744X. PMID 20419280.

External links

Cytidine MS Spectrum

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Original source: https://en.wikipedia.org/wiki/Cytidine. Read more

[crc97-1] 1.0 ^1.1 ^1.2 William M. Haynes (2016). CRC Handbook of Chemistry and Physics (97th ed.). Boca Raton: CRC Press. pp. 3–140. ISBN 978-1-4987-5429-3. https://books.google.com/books?id=VVezDAAAQBAJ.

[hawleys-2] 2.0 ^2.1 Robert A. Lewis, Michael D. Larrañaga, Richard J. Lewis Sr. (2016). Hawley's Condensed Chemical Dictionary (16th ed.). Hoboken, New Jersey: John Wiley & Sons, Inc.. p. 688. ISBN 978-1-118-13515-0.

[Jonas-3] 3.0 ^3.1 Jonas DA; Elmadfa I; Engel KH et al. (2001). "Safety considerations of DNA in food". Ann Nutr Metab 45 (6): 235–54. doi:10.1159/000046734. PMID 11786646. http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=anm45235.

[4] "Effect of oral CDP-choline on plasma choline and uridine levels in humans". Biochem. Pharmacol. 60 (7): 989–92. Oct 2000. doi:10.1016/S0006-2952(00)00436-6. PMID 10974208.

[5] John S. James. "New Kind of Antiretroviral, KP-1461". AIDS Treatment News. http://www.aidsnews.org/2007/10/kp-1461.html.

[6] "Scientists reprogram cancer cells with low doses of epigenetic drugs". Medical XPress. March 22, 2012. http://medicalxpress.com/news/2012-03-scientists-reprogram-cancer-cells-doses.html.

[Machado-VieiraSalvadore2010-7] 7.0 ^7.1 Machado-Vieira, Rodrigo; Salvadore, Giacomo; DiazGranados, Nancy; Ibrahim, Lobna; Latov, David; Wheeler-Castillo, Cristina; Baumann, Jacqueline; Henter, Ioline D. et al. (2010). "New Therapeutic Targets for Mood Disorders". The Scientific World Journal 10: 713–726. doi:10.1100/tsw.2010.65. ISSN 1537-744X. PMID 20419280.

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