DCPG

DCPG
Identifiers
	IUPAC name 4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]phthalic acid;
CAS Number	201730-11-2 ;
PubChem CID	16062593;
IUPHAR/BPS	1407;
ChemSpider	17222214 ;
UNII	W3Y53JA9W3;
Chemical and physical data
Formula	C10H9NO6
Molar mass	239.183 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(O)[C@@H](N)c1cc(c(C(=O)O)cc1)C(=O)O;
	InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1 ; Key:IJVMOGKBEVRBPP-ZETCQYMHSA-N ;
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Short description: Chemical

DCPG ((S)-3,4-DCPG) is a drug used in scientific research, which acts as a potent and subtype-selective agonist for the metabotropic glutamate receptor mGluR₈. It has anticonvulsant effects in animal studies,^[1]^[2] and has also been investigated as a possible treatment for hyperalgesia.^[3]

References

↑ "Glutamate metabotropic receptors as targets for drug therapy in epilepsy". European Journal of Pharmacology 476 (1–2): 3–16. August 2003. doi:10.1016/s0014-2999(03)02149-6. PMID 12969743.
↑ "Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid". Neuropharmacology 54 (4): 665–75. March 2008. doi:10.1016/j.neuropharm.2007.11.015. PMID 18191956.
↑ "Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice". Neuropharmacology 52 (2): 253–62. February 2007. doi:10.1016/j.neuropharm.2006.04.006. PMID 17113112.

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[1] "Glutamate metabotropic receptors as targets for drug therapy in epilepsy". European Journal of Pharmacology 476 (1–2): 3–16. August 2003. doi:10.1016/s0014-2999(03)02149-6. PMID 12969743.

[2] "Anticonvulsant and neuroprotective effect of (S)-3,4-dicarboxyphenylglycine against seizures induced in immature rats by homocysteic acid". Neuropharmacology 54 (4): 665–75. March 2008. doi:10.1016/j.neuropharm.2007.11.015. PMID 18191956.

[3] "Effects of (S)-3,4-DCPG, an mGlu8 receptor agonist, on inflammatory and neuropathic pain in mice". Neuropharmacology 52 (2): 253–62. February 2007. doi:10.1016/j.neuropharm.2006.04.006. PMID 17113112.

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Identifiers

IUPAC name 4-[(1S)-1-amino-2-hydroxy-2-oxoethyl]phthalic acid
CAS Number	201730-11-2^Y
PubChem CID	16062593
IUPHAR/BPS	1407
ChemSpider	17222214^N
UNII	W3Y53JA9W3
Chemical and physical data
Formula	C₁₀H₉NO₆
Molar mass	239.183 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C(O)[C@@H](N)c1cc(c(C(=O)O)cc1)C(=O)O
InChI InChI=1S/C10H9NO6/c11-7(10(16)17)4-1-2-5(8(12)13)6(3-4)9(14)15/h1-3,7H,11H2,(H,12,13)(H,14,15)(H,16,17)/t7-/m0/s1^N Key:IJVMOGKBEVRBPP-ZETCQYMHSA-N^N
^NY (what is this?) (verify)

DCPG

Topic: Chemistry

References