FPPQ

FPPQ is an experimental drug related to quipazine, which acts as a selective antagonist of both the 5-HT₃ and 5-HT₆ serotonin receptors. It has antipsychotic and memory-enhancing effects in animal studies.^[1]^[2]

References

↑ "Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT₃ and 5-HT₆ Receptor Antagonist with Antipsychotic and Procognitive Properties". Journal of Medicinal Chemistry 64 (18): 13279–13298. September 2021. doi:10.1021/acs.jmedchem.1c00224. PMID 34467765.
↑ "Dual 5-HT3 and 5-HT6 Receptor Antagonist FPPQ Normalizes Phencyclidine-Induced Disruption of Brain Oscillatory Activity in Rats". The International Journal of Neuropsychopharmacology 25 (5): 425–431. May 2022. doi:10.1093/ijnp/pyac003. PMID 35022720.

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[1] "Structure-Based Design and Optimization of FPPQ, a Dual-Acting 5-HT₃ and 5-HT₆ Receptor Antagonist with Antipsychotic and Procognitive Properties". Journal of Medicinal Chemistry 64 (18): 13279–13298. September 2021. doi:10.1021/acs.jmedchem.1c00224. PMID 34467765.

[2] "Dual 5-HT3 and 5-HT6 Receptor Antagonist FPPQ Normalizes Phencyclidine-Induced Disruption of Brain Oscillatory Activity in Rats". The International Journal of Neuropsychopharmacology 25 (5): 425–431. May 2022. doi:10.1093/ijnp/pyac003. PMID 35022720.

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FPPQ

Topic: Chemistry

References