Fentanyl tropane
Topic: Chemistry
From HandWiki - Reading time: 6 min
Short description: Chemical compound
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| Formula | C24H30N2O |
| Molar mass | 362.517 g·mol−1 |
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Fentanyl tropane (tropafentanyl) is an opioid derivative which is an analogue of fentanyl, where the central piperidine ring has been bridged with a two carbon chain to form a tropane ring. It is made from tropinone in a similar manner to how fentanyl is made from 4-piperidone, and has two isomers, with the 3β isomer being around half the potency of fentanyl while the 3α isomer is much weaker, only around the same potency as morphine.[1][2]
See also
- Fentanyl azepane
- Secofentanyl
- Phenaridine
- List of fentanyl analogues
References
- ↑ "4-Anilidopiperidine analgesics. 2. A study of the conformational aspects of the analgesic activity of the 4-anilidopiperidines utilizing isomeric N-substituted 3-(propananilido)nortropane analogues". Journal of Medicinal Chemistry 22 (10): 1167–71. October 1979. doi:10.1021/jm00196a004. PMID 513063.
- ↑ Central Analgetics. Wiley. 1982. p. 188-189. ISBN 0-471-08314-3.
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