GSK-789,472

GSK-789,472
Clinical data
ATC code	none;
Identifiers
	IUPAC name 4,5-dihydro-1-phenyl-3-(piperidin-2-yl)methylimidazol-2(1H)one;
CAS Number	1257326-24-1;
ChemSpider	59650715;
Chemical and physical data
Formula	C15H21N3O
Molar mass	259.353 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1N(CC2NCCCC2)CCN1C3=CC=CC=C3;
	InChI InChI=1S/C15H21N3O/c19-15-17(12-13-6-4-5-9-16-13)10-11-18(15)14-7-2-1-3-8-14/h1-3,7-8,13,16H,4-6,9-12H2; Key:MGPOBHIJMZQPIK-UHFFFAOYSA-N;
	(verify)

GSK-789,472 is a drug which acts as both a potent and selective partial agonist at the dopamine receptor D₂, as well as an antagonist at the related D₃ subtype, but with good selectivity over D₄ and other unrelated receptors.^[1]

References

↑ "The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure". Bioorganic & Medicinal Chemistry Letters 20 (6): 2013–6. March 2010. doi:10.1016/j.bmcl.2010.01.090. PMID 20153647.

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[pmid20153647-1] "The identification of a selective dopamine D2 partial agonist, D3 antagonist displaying high levels of brain exposure". Bioorganic & Medicinal Chemistry Letters 20 (6): 2013–6. March 2010. doi:10.1016/j.bmcl.2010.01.090. PMID 20153647.

[1]

Clinical data

ATC code	none
Identifiers
IUPAC name 4,5-dihydro-1-phenyl-3-(piperidin-2-yl)methylimidazol-2(1H)one
CAS Number	1257326-24-1
ChemSpider	59650715
Chemical and physical data
Formula	C₁₅H₂₁N₃O
Molar mass	259.353 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES O=C1N(CC2NCCCC2)CCN1C3=CC=CC=C3
InChI InChI=1S/C15H21N3O/c19-15-17(12-13-6-4-5-9-16-13)10-11-18(15)14-7-2-1-3-8-14/h1-3,7-8,13,16H,4-6,9-12H2 Key:MGPOBHIJMZQPIK-UHFFFAOYSA-N
(verify)

GSK-789,472

Topic: Chemistry

References