Galnon

Galnon
Identifiers
	IUPAC name 9H-fluoren-9-ylmethyl N-[(2S)-1-([(2S)-6-amino-1-[(4-methyl-2-oxochromen-7- yl)amino]-1-oxohexan-2-yl]amino)-3-cyclohexyl-1-oxopropan-2-yl]carbamate;
CAS Number	475115-35-6 ;
PubChem CID	5311268;
IUPHAR/BPS	6118;
ChemSpider	4470781 ;
ChEMBL	ChEMBL592414 ;
Chemical and physical data
Formula	C40H46N4O6
Molar mass	678.815 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Cc3cc(=O)oc6cc(ccc36)NC(=O)C(CCCCN)NC(=O)C(CC5CCCCC5)NC(=O)OCC1c2ccccc2-c4c1cccc4;
	InChI InChI=1S/C40H46N4O6/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)42-38(46)34(17-9-10-20-41)43-39(47)35(22-26-11-3-2-4-12-26)44-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33/h5-8,13-16,18-19,21,23,26,33-35H,2-4,9-12,17,20,22,24,41H2,1H3,(H,42,46)(H,43,47)(H,44,48)/t34-,35-/m0/s1 ; Key:IKNOZZKXIDSTRN-PXLJZGITSA-N ;
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Short description: Chemical compound

Galnon is a drug which acts as a selective, non-peptide agonist at the galanin receptors GAL_R.^[1]^[2] It has anticonvulsant, anxiolytic, anorectic and amnestic effects in animal studies.^[3]^[4]^[5]^[6]^[7]

References

↑ "Anticonvulsant activity of a nonpeptide galanin receptor agonist". Proceedings of the National Academy of Sciences of the United States of America 99 (10): 7136–41. May 2002. doi:10.1073/pnas.102163499. PMID 12011470. Bibcode: 2002PNAS...99.7136S.
↑ "Galnon--a low-molecular weight ligand of the galanin receptors". Neuropeptides 39 (3): 161–3. June 2005. doi:10.1016/j.npep.2004.12.019. PMID 15944006.
↑ "Regulation of feeding by galnon". Neuropeptides 38 (1): 55–61. February 2004. doi:10.1016/j.npep.2004.01.001. PMID 15003717.
↑ "Effect of galnon on induction of long-term potentiation in dentate gyrus of C57BL/6 mice". Neuropeptides 39 (3): 249–51. June 2005. doi:10.1016/j.npep.2004.12.010. PMID 15944018.
↑ "Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon". Neuropeptides 41 (5): 307–20. October 2007. doi:10.1016/j.npep.2007.05.001. PMID 17637475.
↑ "The role of the galaninergic system in modulating stress-related responses in an animal model of posttraumatic stress disorder". Biological Psychiatry 65 (5): 383–91. March 2009. doi:10.1016/j.biopsych.2008.10.034. PMID 19095221.
↑ "Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice". Psychopharmacology 204 (1): 95–102. May 2009. doi:10.1007/s00213-008-1438-7. PMID 19099295.

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Identifiers

IUPAC name 9H-fluoren-9-ylmethyl N-[(2S)-1-([(2S)-6-amino-1-[(4-methyl-2-oxochromen-7- yl)amino]-1-oxohexan-2-yl]amino)-3-cyclohexyl-1-oxopropan-2-yl]carbamate
CAS Number	475115-35-6^Y
PubChem CID	5311268
IUPHAR/BPS	6118
ChemSpider	4470781^N
ChEMBL	ChEMBL592414^N
Chemical and physical data
Formula	C₄₀H₄₆N₄O₆
Molar mass	678.815 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Cc3cc(=O)oc6cc(ccc36)NC(=O)C(CCCCN)NC(=O)C(CC5CCCCC5)NC(=O)OCC1c2ccccc2-c4c1cccc4
InChI InChI=1S/C40H46N4O6/c1-25-21-37(45)50-36-23-27(18-19-28(25)36)42-38(46)34(17-9-10-20-41)43-39(47)35(22-26-11-3-2-4-12-26)44-40(48)49-24-33-31-15-7-5-13-29(31)30-14-6-8-16-32(30)33/h5-8,13-16,18-19,21,23,26,33-35H,2-4,9-12,17,20,22,24,41H2,1H3,(H,42,46)(H,43,47)(H,44,48)/t34-,35-/m0/s1^N Key:IKNOZZKXIDSTRN-PXLJZGITSA-N^N
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