HEPPS (buffer)

HEPPS
Names
	Preferred IUPAC name 3-[4-(2-Hydroxyethyl)piperazin-1-yl]propane-1-sulfonic acid
	Other names HEPPS, EPPS
Identifiers
CAS Number	16052-06-5;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:42298 ;
ChemSpider	76886 ;
PubChem CID	85255;
UNII	8JN5PQW99C ;
	InChI InChI=1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) Key: OWXMKDGYPWMGEB-UHFFFAOYSA-N ; InChI=1/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15) Key: OWXMKDGYPWMGEB-UHFFFAOYAP;
	SMILES O=S(=O)(O)CCCN1CCN(CCO)CC1;
Properties
Chemical formula	C9H20N2O4S
Molar mass	252.33 g·mol−1
Melting point	(decomposes)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

HEPPS (EPPS) is a buffering agent used in biology and biochemistry. The pKa of HEPPS is 8.00. It is ones of Good's buffers.^[1]

Research on mice with Alzheimer's disease-like amyloid beta plaques has shown that HEPPS can cause the plaques to break up, reversing some of the symptoms in the mice.^[2]^[3]^[4] HEPPS was reported to dissociate amyloid beta oligomers in patients' plasma samples enabling blood diagnosis of Alzheimer's disease.^[5]^[6]^[7]

References

↑ Good, N. E; Winget, G. D; Winter, W; Connolly, T. N; Izawa, S; Singh, R. M (1966). "Hydrogen ion buffers for biological research". Biochemistry 5 (2): 467–77. doi:10.1021/bi00866a011. PMID 5942950.
↑ "Small Molecule Breaks Up Amyloid Aggregates In Mice". Chemical & Engineering News. http://cen.acs.org/articles/93/web/2015/12/Small-Molecule-Breaks-Amyloid-Aggregates.html. Retrieved 14 December 2015.
↑ Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications 6: 8997. doi:10.1038/ncomms9997. PMID 26646366. Bibcode: 2015NatCo...6.8997K.
↑ "Chemical clears Alzheimer's protein and restores memory in mice". MedicalXpress. http://medicalxpress.com/news/2015-12-chemical-alzheimer-protein-memory-mice.html.
↑ Kim, YoungSoo; Yoo, Yong Kyoung; Kim, Hye Yun; Roh, Jee Hoon; Kim, Jinsik; Baek, Seungyeop; Lee, Jinny Claire; Kim, Hye Jin et al. (2019-04-01). "Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system" (in en). Science Advances 5 (4): eaav1388. doi:10.1126/sciadv.aav1388. ISSN 2375-2548. PMID 31001580. Bibcode: 2019SciA....5.1388K.
↑ "Blood Test for Detecting Pre-symptomatic Alzheimer's Disease is Refined" (in en). https://www.technologynetworks.com/analysis/news/blood-test-for-detecting-pre-symptomatic-alzheimers-disease-is-refined-318368.
↑ "A possible blood test for early-stage Alzheimer's disease" (in en-us). https://medicalxpress.com/news/2019-04-blood-early-stage-alzheimer-disease.html.

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[1] Good, N. E; Winget, G. D; Winter, W; Connolly, T. N; Izawa, S; Singh, R. M (1966). "Hydrogen ion buffers for biological research". Biochemistry 5 (2): 467–77. doi:10.1021/bi00866a011. PMID 5942950.

[2] "Small Molecule Breaks Up Amyloid Aggregates In Mice". Chemical & Engineering News. http://cen.acs.org/articles/93/web/2015/12/Small-Molecule-Breaks-Amyloid-Aggregates.html. Retrieved 14 December 2015.

[3] Kim, Hye Yun; Kim, Hyunjin Vincent; Jo, Seonmi; Lee, C. Justin; Choi, Seon Young; Kim, Dong Jin; Kim, YoungSoo (8 December 2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications 6: 8997. doi:10.1038/ncomms9997. PMID 26646366. Bibcode: 2015NatCo...6.8997K.

[4] "Chemical clears Alzheimer's protein and restores memory in mice". MedicalXpress. http://medicalxpress.com/news/2015-12-chemical-alzheimer-protein-memory-mice.html.

[5] Kim, YoungSoo; Yoo, Yong Kyoung; Kim, Hye Yun; Roh, Jee Hoon; Kim, Jinsik; Baek, Seungyeop; Lee, Jinny Claire; Kim, Hye Jin et al. (2019-04-01). "Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system" (in en). Science Advances 5 (4): eaav1388. doi:10.1126/sciadv.aav1388. ISSN 2375-2548. PMID 31001580. Bibcode: 2019SciA....5.1388K.

[6] "Blood Test for Detecting Pre-symptomatic Alzheimer's Disease is Refined" (in en). https://www.technologynetworks.com/analysis/news/blood-test-for-detecting-pre-symptomatic-alzheimers-disease-is-refined-318368.

[7] "A possible blood test for early-stage Alzheimer's disease" (in en-us). https://medicalxpress.com/news/2019-04-blood-early-stage-alzheimer-disease.html.

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v t e Piperazines
Simple piperazines (no additional rings)	1-Cyclohexylpiperazine Aminoethylpiperazine Diethylcarbamazine HEPPS Midafotel Piperazine PIPES
Phenylpiperazines	Acaprazine Antrafenine Aripiprazole Batoprazine Bifeprunox BRL-15,572 Ciprofloxacin CSP-2503 Dapiprazole DCPP DMPP Diphenylpiperazine Dropropizine EGIS-12,233 Elopiprazole Eltoprazine Enpiprazole Ensaculin Etoperidone Flesinoxan Fluanisone Flibanserin Fluprazine Itraconazole Ketoconazole Levodropropizine Lorpiprazole mCPP Mefway MeOPP Mepiprazole Naftopidil Naluzotan Naphthylpiperazine Nefazodone Niaprazine Oxypertine Pardoprunox pCPP pFPP Posaconazole S-14,506 S-14,671 S-15,535 SB-258,585 SB-271,046 SB-357,134 SB-399,885 Sonepiprazole TFMPP Tolpiprazole Trazodone Urapidil Vesnarinone Vilazodone Vortioxetine WAY-100,135 WAY-100,635
Benzylpiperazines	2C-B-BZP Befuraline Bifeprunox Buclizine BZP Chlorbenzoxamine DBZP Fipexide Imatinib MBZP MDBZP Meclozine Methoxypiperamide Piberaline Piribedil Sunifiram Trimetazidine Vesnarinone
Diphenylalkylpiperazines (benzhydrylalkylpiperazines)	AD-1211 Almitrine Amperozide BRL-15,572 Buclizine BW373U86 Cetirizine Chlorbenzoxamine Chlorcyclizine Cinnarizine Clocinizine Cyclizine DBL-583 Diphenpipenol Diphenylmethylpiperazine Dotarizine DPI-221 DPI-287 DPI-3290 GBR-12,783 GBR-12,935 GBR-13,069 GBR-13,098 GBR-13,119 Hydroxyzine Lidoflazine Manidipine Meclozine MT-45 Oxatomide SNC-80 Vanoxerine
Pyrimidinylpiperazines	Buspirone Dasatinib Eptapirone Gepirone Ipsapirone Piribedil Prazitone Pyrimidinylpiperazine Revospirone Tandospirone Tirilazad Trimazosin Umespirone Zalospirone
Pyridinylpiperazines	Atevirdine Azaperone Delavirdine Mirtazapine Pyridinylpiperazine
Benzo(iso)thiazolyl piperazines	Lurasidone Perospirone Revospirone Tiospirone Ziprasidone
Tricyclics (piperazine attached via side chain)	Amoxapine Clopenthixol Clorotepine Clozapine Cyanothepin Doclothepin Docloxythepin Flupentixol Fluphenazine Isofloxythepin Loxapine Meperathiepin Metitepine Octomethothepin Olanzapine Opipramol Oxyclothepin Oxyprothepin Peradithiepin Perathiepin Perazine Perphenazine Pirenzepine Prochlorperazine Thiethylperazine Thiothixene Trifluoperazine Trifluthepin Zuclopenthixol
Others/Uncategorized	6-Nitroquipazine Azimilide Cinepazet Cinepazic acid Cinepazide Cyclohexylpiperazine EGIS-7625 Hexocyclium Indinavir JNJ-7777120 Lodenafil Mirodenafil PB-28 Quipazine Ranolazine SA-4503 Sildenafil Tadalafil Vardenafil VUF-6002 WY-46824 Zipeprol

HEPPS (buffer)

Topic: Chemistry

See also

References