Histamine trifluoromethyl toluidide
Topic: Chemistry
From HandWiki - Reading time: 4 min
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| Names | |
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| IUPAC name
6-[2-(1H-imidazol-5-yl)ethylamino]-N-[4-(trifluoromethyl)phenyl]heptanamide
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| Other names
HTFMT, HTMT
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| Identifiers | |
3D model (JSmol)
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PubChem CID
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| Properties | |
| C19H25F3N4O | |
| Molar mass | 382.42321 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). | |
 verify (what is   ?)
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| Infobox references | |
Tracking categories (test):
Histamine trifluoromethyl toluidide (HTFMT) is a mixed H1/H2 histamine agonist which is significantly more potent than histamine itself.[1]
It also produces additional actions which appear to be independent of histamine receptors.[2][3]
References
- ↑ Whyment, AD; Blanks, AM; Lee, K; Renaud, LP; Spanswick, D (Apr 2006). "Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors". Journal of Neurophysiology 95 (4): 2492–500. doi:10.1152/jn.01135.2004. PMID 16354729.
- ↑ Qiu, R; Melmon, KL; Khan, MM (Jun 1990). "Effects of histamine-trifluoromethyl-toluidide derivative (HTMT) on intracellular calcium in human lymphocytes.". Journal of Pharmacology and Experimental Therapeutics 253 (3): 1245–52. doi:10.1016/S0022-3565(25)13228-X. PMID 2359026.
- ↑ Kim, DC; Lee, SY; Jun, DJ; Kim, SH; Lee, JH; Hur, EM; Baek, NI; Kim, KT (Nov 2005). "Inhibition of store-operated calcium entry-mediated superoxide generation by histamine trifluoromethyltoluide independent of histamine receptors". Biochemical Pharmacology 70 (11): 1613–22. doi:10.1016/j.bcp.2005.09.001. PMID 16219299.
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