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Insect repellent

Topic: Chemistry

 From HandWiki - Reading time: 14 min
Short description: Substance which repels insects
A mosquito coil

An insect repellent (also commonly called "bug spray") is a substance applied to the skin, clothing, or other surfaces to discourage insects (and arthropods in general) from landing or climbing on that surface. Insect repellents help prevent and control the outbreak of insect-borne (and other arthropod-bourne) diseases such as malaria, Lyme disease, dengue fever, bubonic plague, river blindness, and West Nile fever. Pest animals commonly serving as vectors for disease include insects such as flea, fly, and mosquito; and ticks (arachnids). [citation needed]

Some insect repellents are insecticides (bug killers), but most simply discourage insects and send them flying or crawling away. Nearly any would be fatal upon reaching the median lethal dose, but classification as an insecticide implies death even at lower doses.

Effectiveness

Synthetic repellents tend to be more effective and/or longer lasting than "natural" repellents.[1][2]

For protection against mosquito bites, the U.S. Centers for Disease Control (CDC) recommends DEET, icaridin (picaridin, KBR 3023), oil of lemon eucalyptus (para-menthane-diol or PMD), IR3535 and 2-undecanone with the caveat that higher percentages of the active ingredient provide longer protection.[3]

In 2015, Researchers at New Mexico State University tested 10 commercially available products for their effectiveness at repelling mosquitoes. On the mosquito Aedes aegypti, the vector of Zika virus, only one repellent that did not contain DEET had a strong effect for the duration of the 240 minutes test: a lemon eucalyptus oil repellent. All DEET-containing mosquito repellents were active.[4]

In one comparative study from 2004, IR3535 was as effective or better than DEET in protection against Aedes aegypti and Culex quinquefasciatus mosquitoes.[5] Other sources (official publications of the associations of German physicians[6] as well as of German druggists[7]) suggest the contrary and state DEET is still the most efficient substance available and the substance of choice for stays in malaria regions, while IR3535 has little effect. However, some plant-based repellents may provide effective relief as well.[1][2][8] Essential oil repellents can be short-lived in their effectiveness.[9]

A test of various insect repellents by an independent consumer organization found that repellents containing DEET or icaridin are more effective than repellents with "natural" active ingredients. All the synthetics gave almost 100% repellency for the first 2 hours, where the natural repellent products were most effective for the first 30 to 60 minutes, and required reapplication to be effective over several hours.[10]

Although highly toxic to cats, permethrin is recommended as protection against mosquitoes for clothing, gear, or bed nets.[11] In an earlier report, the CDC found oil of lemon eucalyptus to be more effective than other plant-based treatments, with a similar effectiveness to low concentrations of DEET.[12] However, a 2006 published study found in both cage and field studies that a product containing 40% oil of lemon eucalyptus was just as effective as products containing high concentrations of DEET.[13] Research has also found that neem oil is mosquito repellent for up to 12 hours.[8] Citronella oil's mosquito repellency has also been verified by research,[14] including effectiveness in repelling Aedes aegypti,[15] but requires reapplication after 30 to 60 minutes.

There are also products available based on sound production, particularly ultrasound (inaudibly high-frequency sounds) which purport to be insect repellents. However, these electronic devices have been shown to be ineffective based on studies done by the United States Environmental Protection Agency and many universities.[16]

Safety issues

For humans

DEET
Icaridin
p-Menthane-3,8-diol (PMD)

Children may be at greater risk for adverse reactions to repellents, in part, because their exposure may be greater. Children can be at greater risk of accidental eye contact or ingestion. As with chemical exposures in general, pregnant women should take care to avoid exposures to repellents when practical, as the fetus may be vulnerable.

Some experts also recommend against applying chemicals such as DEET and sunscreen simultaneously since that would increase DEET penetration. Canadian researcher, Xiaochen Gu, a professor at the University of Manitoba's faculty of Pharmacy who led a study about mosquitos, advises that DEET should be applied 30 or more minutes later. Gu also recommends insect repellent sprays instead of lotions which are rubbed into the skin "forcing molecules into the skin".[17]

Regardless of which repellent product used, it is recommended to read the label before use and carefully follow directions.[18] Usage instructions for repellents vary from country to country. Some insect repellents are not recommended for use on younger children.[3]

In the DEET Reregistration Eligibility Decision (RED) the United States Environmental Protection Agency (EPA) reported 14 to 46 cases of potential DEET associated seizures, including 4 deaths. The EPA states: "... it does appear that some cases are likely related to DEET toxicity," but observed that with 30% of the US population using DEET, the likely seizure rate is only about one per 100 million users.[19]

The Pesticide Information Project of Cooperative Extension Offices of Cornell University states that, "Everglades National Park employees having extensive DEET exposure were more likely to have insomnia, mood disturbances and impaired cognitive function than were lesser exposed co-workers".[20]

The EPA states that citronella oil shows little or no toxicity and has been used as a topical insect repellent for 60 years. However, the EPA also states that citronella may irritate skin and cause dermatitis in certain individuals.[21] Canadian regulatory authorities concern with citronella based repellents is primarily based on data-gaps in toxicology, not on incidents.[22][23]

Within countries of the European Union, implementation of Regulation 98/8/EC,[24] commonly referred to as the Biocidal Products Directive, has severely limited the number and type of insect repellents available to European consumers. Only a small number of active ingredients have been supported by manufacturers in submitting dossiers to the EU Authorities.

In general, only formulations containing DEET, icaridin (sold under the trade name Saltidin and formerly known as Bayrepel or KBR3023), IR3535 and citriodiol (p-menthane-3,8-diol) are available. Most "natural" insect repellents such as citronella, neem oil, and herbal extracts are no longer permitted for sale as insect repellents in the EU due to their lack of effectiveness; this does not preclude them from being sold for other purposes, as long as the label does not indicate they are a biocide (insect repellent).[citation needed]

Toxicity for other animals

A 2018 study found that Icaridin, is highly toxic to salamander larvae, in what the authors described as conservative exposure doses.[25] The LC50 standard was additionally found to be completely inadequate in the context of finding this result.[26]

Permethrin is highly toxic to cats but not to dogs or humans.[27]

Common insect repellents

Common synthetic insect repellents

  • Benzaldehyde, for bees[28]
  • Butopyronoxyl (trade name Indalone). Widely used in a "6-2-2" mixture (60% Dimethyl phthalate, 20% Indalone, 20% Ethylhexanediol) during the 1940s and 1950s before the commercial introduction of DEET
  • DEET (N,N-diethyl-m-toluamide)
  • Dimethyl carbate
  • Dimethyl phthalate, not as common as it once was but still occasionally an active ingredient in commercial insect repellents
  • Ethyl butylacetylaminopropionate (IR3535 or 3-[N-Butyl-N-acetyl]-aminopropionic acid, ethyl ester)
  • Ethylhexanediol, also known as Rutgers 612 or "6–12 repellent," discontinued in the US in 1991 due to evidence of causing developmental defects in animals[29]
  • Icaridin, also known as picaridin, Bayrepel, and KBR 3023
  • Methyl anthranilate and other anthranilate-based insect repellents
  • Metofluthrin
  • Permethrin is a contact insecticide rather than a repellent
  • SS220 is a repellent being researched that has shown promise to provide significantly better protection than DEET
  • Tricyclodecenyl allyl ether, a compound often found in synthetic perfumes[30][31]

Common natural insect repellents

A cowhorn container for mosquito-repelling pitch oil (a by-product of the distillation of wood tar) on display at the Nordiska museum, Stockholm.[32]

Insect repellents from natural sources

A mosquito on a bottle of "natural" insect repellent

Several natural ingredients are certified by the United States Environmental Protection Agency as insect repellents, namely catnip oil, oil of lemon eucalyptus (OLE) (and its active ingredient p-Menthane-3,8-diol), oil of citronella, and 2-Undecanone, which is usually produced synthetically but has also been isolated from many plant sources.[37]

Many other studies have also investigated the potential of natural compounds from plants as insect repellents.[38][39][40] Moreover, there are many preparations from naturally occurring sources that have been used as a repellent to certain insects. Some of these act as insecticides while others are only repellent. Below is a list of some natural products with repellent activity:

Less effective methods

Some old studies suggested that the ingestion of large doses of thiamine (vitamin B1) could be effective as an oral insect repellent against mosquito bites. However, there is now conclusive evidence that thiamin has no efficacy against mosquito bites.[69][70][71][72] Some claim that plants such as wormwood or sagewort, lemon balm, lemon grass, lemon thyme, and the mosquito plant (Pelargonium) will act against mosquitoes. However, scientists have determined that these plants are "effective" for a limited time only when the leaves are crushed and applied directly to the skin.[73]

There are several, widespread, unproven theories about mosquito control, such as the assertion that vitamin B, in particular B1 (thiamine), garlic, ultrasonic devices or incense can be used to repel or control mosquitoes.[70][74] Moreover, manufacturers of "mosquito repelling" ultrasonic devices have been found to be fraudulent,[75] and their devices were deemed "useless" according to a review of scientific studies.[76]

Alternatives to repellent

People can reduce the number of mosquito bites they receive (to a greater or lesser degree) by:

  • Using a mosquito net
  • Wearing long clothing that covers the skin and is tucked in to seal up holes[77]
  • Avoiding the outdoors during dawn and dusk, when mosquitos are most active[77]
  • Keeping air moving to prevent mosquitos from landing, such as by using a fan[77]
  • Wearing light-colored clothing (light objects are harder for mosquitos to detect)[78]
  • Reducing exercise, which reduces output of carbon dioxide used by mosquitos for detection[78]

History

Testing and scientific certainty were desired at the end of the 1940s. To that end products meant to be used by humans were tested with model animals to speed trials. Eddy & McGregor 1949 and Wiesmann & Lotmar 1949 used mice, Wasicky et al. 1949 canaries and guinea pigs, Kasman et al. 1953 also guinea pigs, Starnes & Granett 1953 rabbits, and many used cattle.[79]

See also

References

  1. ↑ 1.0 1.1 "Comparative efficacy of insect repellents against mosquito bites". The New England Journal of Medicine 347 (1): 13–8. July 2002. doi:10.1056/NEJMoa011699. PMID 12097535. 
  2. ↑ 2.0 2.1 "Assessment of the efficacy of Quwenling as a Mosquito repellent". Phytotherapy Research 7 (1): 17–20. 1993. doi:10.1002/ptr.2650070106. 
  3. ↑ 3.0 3.1 "Updated Information regarding Insect Repellents". Centers for Disease Control and Prevention. 14 August 2017. https://www.cdc.gov/ncidod/dvbid/westnile/repellentupdates.htm. 
  4. ↑ Rodriguez, Stacy D.; Drake, Lisa L.; Price, David P.; Hammond, John I.; Hansen, Immo A. (October 2015). "The Efficacy of Some Commercially Available Insect Repellents for Aedes aegypti (Diptera: Culicidae) and Aedes albopictus (Diptera: Culicidae)". Journal of Insect Science 15 (1): 140. doi:10.1093/jisesa/iev125. PMID 26443777. 
  5. ↑ "Comparative efficacy of IR3535 and deet as repellents against adult Aedes aegypti and Culex quinquefasciatus". Journal of the American Mosquito Control Association 20 (3): 299–304. September 2004. PMID 15532931. 
  6. ↑ "Insektenschutz: Wie man das Stichrisiko senkt". 2013-07-22. http://www.aerzteblatt.de/archiv/143452/Insektenschutz-Wie-man-das-Stichrisiko-senkt. 
  7. ↑ "Repellentien und Insektizide: Erfolgreich gegen den Insektenangriff". http://www.pharmazeutische-zeitung.de/index.php?id=5363&type=0. 
  8. ↑ 8.0 8.1 "Mosquito repellent action of neem (Azadirachta indica) oil". Journal of the American Mosquito Control Association 9 (3): 359–360. 31 August 1993. PMID 8245950. 
  9. ↑ Sritabutra, Duangkamon; Soonwera, Mayura; Waltanachanobon, Sirirat; Poungjai, Supaporn (September 2011). "Evaluation of herbal essential oil as repellents against Aedes aegypti (L.) and Anopheles dirus Peyton & Harrion". Asian Pacific Journal of Tropical Biomedicine 1 (1): S124–S128. doi:10.1016/S2221-1691(11)60138-X. 
  10. ↑ "Test: Mosquito Repellents, The Verdict" Choice, The Australian Consumers Association
  11. ↑ "Protection against Mosquitoes, Ticks, & Other Arthropods", U.S. Centers for Disease Control
  12. ↑ "Insect Repellent Use and Safety". West Nile Virus. Centers for Disease Control and Prevention. 12 January 2007. https://www.cdc.gov/ncidod/dvbid/westnile/qa/insect_repellent.htm. 
  13. ↑ Carroll SP, Loye J, 2006, Journal of the American Mosquito Control Association 22(3):507–514, 510
  14. ↑ Jeong-Kyu KIM, Chang-Soo KANG, Jong-Kwon LEE, Young-Ran KIM, Hye-Yun HAN, Hwa Kyung YUN, Evaluation of Repellency Effect of Two Natural Aroma Mosquito Repellent Compounds, Citronella and Citronellal, Entomological Research 35 (2), 117–120, 2005
  15. ↑ Ibrahim Jantan, and Zaridah Mohd. Zaki, Development of environment-friendly insect repellents from the leaf oils of selected Malaysian plants, ASEAN Review of Biodiversity and Environmental Conservation (ARBEC), May 1998.
  16. ↑ "Mosquito repellents that emit high-pitched sounds don't prevent bites" (Press release). Eurekalert!. April 17, 2007.
  17. ↑ "How to choose the best bug repellent". Reader's Digest Association, Inc.. January 2000. http://www.besthealthmag.ca/best-you/prevention/how-to-choose-the-best-bug-repellent. "‘Anything intended for topical use only shouldn’t be going into the body,’ says Xiaochen Gu, a professor at the University of Manitoba’s faculty of pharmacy, who led the study." 
  18. ↑ ""Health Advisory: Tick and Insect Repellents", Information factsheet, Department of Health, New York State". http://www.health.ny.gov/publications/2737/. 
  19. ↑ "Reregistration Eligibility Decision: DEET." U.S. Environmental Protection Agency, Office of Prevention, Pesticides, and Toxic Substances. September 1998. pp39-40
  20. ↑ Deet
  21. ↑ 21.0 21.1 "Citronella (Oil of Citronella) (021901) Fact Sheet". United States Environmental Protection Agency. 16 February 2011. http://www.epa.gov/oppbppd1/biopesticides/ingredients/factsheets/factsheet_021901.htm. 
  22. ↑ Re-evaluation of Citronella Oil and Related Active Compounds for Use as Personal Insect Repellents. Pest Management Regulatory Agency (Canada). 17 September 2004. ISBN 978-0-662-38012-2. http://www.pmra-arla.gc.ca/english/pdf/pacr/pacr2004-36-e.pdf. 
  23. ↑ "So Then: Who’s Afraid of Citronella Oil? Update!" Cropwatch Newsletter Vol 2, Issue 1, No. 1
  24. ↑ "Directive 98/8/EC of the European Parliament and of the Council of 16 February 1998 concerning the placing of biocidal products on the market". Official Journal of the European Communities. 16 February 1998. http://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:1998:123:0001:0063:EN:PDF. 
  25. ↑ "High mortality in aquatic predators of mosquito larvae caused by exposure to insect repellent". Biology Letters 14 (10): 20180526. October 2018. doi:10.1098/rsbl.2018.0526. PMID 30381452. 
  26. ↑ "Widely used mosquito repellent proves lethal to larval salamanders". ScienceDaily. 31 October 2018. https://www.sciencedaily.com/releases/2018/10/181031080627.htm. 
  27. ↑ Roberts, Catherine (22 October 2018). "Should You Use Natural Tick Prevention for Your Dog or Cat?". Consumer Reports Inc.. https://www.consumerreports.org/pets/should-you-use-natural-tick-prevention-for-your-dog-or-cat/. 
  28. ↑ Evans, Elizabeth; Butler, Carol (2010-02-09). Why Do Bees Buzz?: Why Do Bees Buzz? Fascinating Answers to Questions about Bees. Rutgers University Press. pp. 177–178. ISBN 9780813549200. https://books.google.com/books?id=xzQ4NWlIrHwC&pg=PA177. 
  29. ↑ "Brown, Maryland Extension Service leaflet 10". http://www.entmclasses.umd.edu/peap/leaflets/PIL10.pdf. 
  30. ↑ Insect Repellents – Patent 6660288
  31. ↑ Detailed patent information
  32. ↑ Comparisons explanatory text in the display: https://commons.wikimedia.org/wiki/File:Oil_Jar_in_cow_horn_for_mosquito-repelling_pitch_oil.JPG
  33. ↑ "Birch bark used as mosquito repellent". http://www.sacredearth.com/ethnobotany/plantprofiles/birch.php. 
  34. ↑ Are Citronella Candles an Effective Mosquito Repellent?
  35. ↑ Micro Wave: Why Mosquitoes Bite You More Than Your Friends
  36. ↑ 36.0 36.1 U.S. Patent 5,738,863
  37. ↑ "Skin-Applied Repellent Ingredients". 18 July 2013. https://www.epa.gov/insect-repellents/skin-applied-repellent-ingredients. 
  38. ↑ "Exploring the Potentiality of Natural Products from Essential Oils as Inhibitors of Odorant-Binding Proteins: A Structure- and Ligand-Based Virtual Screening Approach To Find Novel Mosquito Repellents". ACS Omega 4 (27): 22475–22486. December 2019. doi:10.1021/acsomega.9b03157. PMID 31909330. 
  39. ↑ Oliveira, Pedro Lagerblad, ed (2013-09-06). "Promising Aedes aegypti repellent chemotypes identified through integrated QSAR, virtual screening, synthesis, and bioassay". PLOS ONE 8 (9): e64547. doi:10.1371/journal.pone.0064547. PMID 24039693. Bibcode: 2013PLoSO...864547O. 
  40. ↑ "Identification of novel bioinspired synthetic mosquito repellents by combined ligand-based screening and OBP-structure-based molecular docking". Insect Biochemistry and Molecular Biology 98: 48–61. July 2018. doi:10.1016/j.ibmb.2018.05.001. PMID 29751047. 
  41. ↑ 41.0 41.1 41.2 41.3 41.4 41.5 41.6 41.7 Abrol, D. P.; Shankar, Uma (2012) (in en). Integrated Pest Management: Principles and Practice. CABI. pp. 152–153. ISBN 978-1-84593-808-6. https://books.google.com/books?id=0V7QBa4PIXsC&q=Insect+repellent+Achillea+alpina&pg=PA152. 
  42. ↑ "Repellent activities of essential oils and monoterpenes against Culex pipiens pallens". Journal of the American Mosquito Control Association 18 (4): 348–51. December 2002. PMID 12542193. 
  43. ↑ Govindarajan M., Sivakumar R. " Adulticidal and repellent properties of indigenous plant extracts against Culex quinquefasciatus and Aedes aegypti (Diptera: Culicidae). Parasitol Res. 2011 Oct 20.
  44. ↑ Taverne, Janice (2001). "Malaria on the Web and the mosquito-repellent properties of basil". Trends in Parasitology 17 (6): 299–300. doi:10.1016/S1471-4922(01)01978-X. 
  45. ↑ "Isolation and identification of mosquito (Aedes aegypti ) biting deterrent fatty acids from male inflorescences of breadfruit (Artocarpus altilis (Parkinson) Fosberg)". Journal of Agricultural and Food Chemistry 60 (15): 3867–73. April 2012. doi:10.1021/jf300101w. PMID 22420541. 
  46. ↑ "A Granddad's Advice May Help Thwart Mosquitoes". www.sciencedaily.com. https://www.sciencedaily.com/releases/2006/02/060201233218.htm. 
  47. ↑ "Relative efficacy of various oils in repelling mosquitoes". Indian Journal of Malariology 32 (3): 104–11. September 1995. PMID 8936292. 
  48. ↑ "Cimex lectularius under Laboratory Conditions". Journal of Arthropod-Borne Diseases 12 (4): 387–397. December 2018. PMID 30918908. 
  49. ↑ 49.0 49.1 49.2 49.3 49.4 49.5 49.6 "Natural Mosquito Repellents". chemistry.about.com. http://chemistry.about.com/cs/howthingswork/a/aa050503a.htm. 
  50. ↑ "Catnip Repels Mosquitoes More Effectively Than DEET". www.sciencedaily.com. https://www.sciencedaily.com/releases/2001/08/010828075659.htm. 
  51. ↑ "Field evaluation of G10, a celery (Apium graveolens)-based topical repellent, against mosquitoes (Diptera: Culicidae) in Chiang Mai province, northern Thailand". Parasitology Research 104 (3): 515–21. February 2009. doi:10.1007/s00436-008-1224-9. PMID 18853188. 
  52. ↑ "Cinnamon Oil Kills Mosquitoes". www.sciencedaily.com. https://www.sciencedaily.com/releases/2004/07/040716081706.htm. 
  53. ↑ "R.E.D. FACTS: Limonene". EPA – United States Environmental Protection Agency. https://archive.epa.gov/pesticides/reregistration/web/pdf/3083fact.pdf. 
  54. ↑ Batish, Daizy R.; Singh, Harminder Pal; Kohli, Ravinder Kumar; Kaur, Shalinder (2008-12-10). "Eucalyptus essential oil as a natural pesticide". Forest Ecology and Management 256 (12): 2166–2174. doi:10.1016/j.foreco.2008.08.008. 
  55. ↑ Flower and Vegetable Oils, R.E.D. Facts, EPA
  56. ↑ "Identification of the active components of garlic causing repellent effect against the rice weevil and the wheat flour beetle". Nihon Oyo Doubutsu Konchu Gakkai Taikai Koen Youshi 42: 211. 1998. http://sciencelinks.jp/j-east/article/199916/000019991699A0654161.php. Retrieved 22 November 2007. 
  57. ↑ "An appropriate method for extracting the insect repellent citronellol from an indigenous plant (Pelargonium graveolens L'Her) for potential use by resource-limited animal owners". 2000. http://grande.nal.usda.gov/ibids/index.php?mode2=detail&origin=ibids_references&therow=132095. 
  58. ↑ Bentley, Ronald (2008). "A fresh look at natural tropolonoids". Nat. Prod. Rep. 25 (1): 118–138. doi:10.1039/B711474E. PMID 18250899. 
  59. ↑ Pohlit, Adrian; Lopes, Norberto; Gama, Renata; Tadei, Wanderli; de Andrade Neto, Valter (April 2011). "Patent Literature on Mosquito Repellent Inventions which Contain Plant Essential Oils – A Review". Planta Medica 77 (6): 598–617. doi:10.1055/s-0030-1270723. PMID 21328177. 
  60. ↑ "Repellency of oils of lemon eucalyptus, geranium, and lavender and the mosquito repellent MyggA natural to Ixodes ricinus (Acari: Ixodidae) in the laboratory and field". Journal of Medical Entomology 43 (4): 731–6. July 2006. doi:10.1603/0022-2585(2006)43[731:rooole2.0.co;2]. PMID 16892632. 
  61. ↑ Cook, Samantha M.; Jönsson, Martin; Skellern, Matthew P.; Murray, Darren A.; Anderson, Peter; Powell, Wilf (2007). "Responses of Phradis parasitoids to volatiles of lavender, Lavendula angustifolia – a possible repellent for their host, Meligethes aeneus". BioControl 52 (5): 591–598. doi:10.1007/s10526-006-9057-x. 
  62. ↑ "Formulation of an effective mosquito-repellent topical product from lemongrass oil". Phytomedicine 9 (3): 259–62. April 2002. doi:10.1078/0944-7113-00120. PMID 12046869. 
  63. ↑ "BIOPESTICIDES REGISTRATION ACTION DOCUMENT". U.S. Environmental Protection Agency. https://www3.epa.gov/pesticides/chem_search/reg_actions/registration/decision_PC-128838_10-Jun-08.pdf. 
  64. ↑ 64.0 64.1 "Repellent and Oviposition-Deterring Activity of Rosemary and Sweet Marjoram on the Spider Mites Tetranychus urticae and Eutetranychus orientalis (Acari: Tetranychidae)". Acta Phytopathologica et Entomologica Hungarica 36 (1–2): 155–164. 2001. doi:10.1556/APhyt.36.2001.1-2.18. http://real.mtak.hu/62071/1/aphyt.36.2001.1-2.18.pdf. 
  65. ↑ US EPA, OCSPP (10 August 2020). "Nootkatone Now Registered by EPA" (in en). https://www.epa.gov/pesticides/nootkatone-now-registered-epa. 
  66. ↑ "Larvicidal and mosquito repellent action of peppermint (Mentha piperita) oil". Bioresource Technology 71 (3): 267–271. 2000. doi:10.1016/S0960-8524(99)00079-6. 
  67. ↑ Nuwer, Rachel, Natural Mosquito Repellent’s Powers Finally Decoded, Scientific American, August 2021, originally entitled "Buzz Kill" when published in Scientific American 325, 2, 23 (August 2021), doi:10.1038/scientificamerican0821-23
  68. ↑ "Antifeedant and Repellent Effects of Pongam (Pongamia Pinnata) and Wild Sage (Lantana Camara) on Tea Mosquito Bug (Helopeltis Theivora)". Indian Journal of Agricultural Science 68 (5): 274. http://cat.inist.fr/?aModele=afficheN&cpsidt=10690847. Retrieved 22 November 2007. 
  69. ↑ BMJ Clinical Evidence
  70. ↑ 70.0 70.1 "Testing vitamin B as a home remedy against mosquitoes". Journal of the American Mosquito Control Association 21 (2): 213–7. June 2005. doi:10.2987/8756-971X(2005)21[213:TVBAAH2.0.CO;2]. PMID 16033124. 
  71. ↑ "Vitamin B1 is not a systemic mosquito repellent in man". Transactions of the St. John's Hospital Dermatological Society 55 (1): 99–102. 2005. PMID 4389912. 
  72. ↑ "Drugs and disease as mosquito repellents in man". The American Journal of Tropical Medicine and Hygiene 17 (3): 461–4. May 1968. doi:10.4269/ajtmh.1968.17.461. PMID 4385133. 
  73. ↑ Medscape: Medscape Access
  74. ↑ "Insect Repellents". DermNet NZ. 5 July 2010. http://dermnetnz.org/treatments/insect-repellents.html. 
  75. ↑ Lentek International-08/28/02
  76. ↑ "Electronic mosquito repellents for preventing mosquito bites and malaria infection". The Cochrane Database of Systematic Reviews 18 (2): CD005434. April 2007. doi:10.1002/14651858.CD005434.pub2. PMID 17443590. PMC 6532582. http://archive.lstmed.ac.uk/977/1/Electronic_mosquito_repellents.pdf. 
  77. ↑ 77.0 77.1 77.2 Natural & Alternative Mosquito Repellents
  78. ↑ 78.0 78.1 Micro Wave: Why Mosquitoes Bite You More Than Your Friends
  79. ↑ Dethier, V. G. (1956). "Repellents". Annual Review of Entomology (Annual Reviews) 1 (1): 181–202. doi:10.1146/annurev.en.01.010156.001145. ISSN 0066-4170. 

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