List of investigational anxiolytics
Topic: Chemistry
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This is a list of investigational anxiolytics, or anxiolytics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in parentheses.
Generalized anxiety disorder
- Riluzole sublingual (BHV-0223) – undefined mechanism of action[1]
- TGFK08AA – 5-HT1A receptor modulator[2]
- TGW00AA (FKW00GA) – 5-HT1A receptor agonist, 5-HT2A receptor antagonist [3]
Panic disorder
- Darigabat (PF-06372865) – GABAA receptor positive allosteric modulator [4]
- JNJ-61393215 – orexin OX1 receptor antagonist [5]
Post-traumatic stress disorder
- 7-Oxoprasterone (7-keto-DHEA; HBL-9001) – "immunomodulator" / undefined mechanism of action [6]
- BNC-210 (IW-2143) – "GABA modulator"[1] / undefined mechanism of action[2][7]
- Brexpiprazole (Lu AF41156, OPC-34712; Rexulti) – atypical antipsychotic / 5-HT1A, D2 and D3 receptor partial agonist and 5-HT2A, 5-HT2B, 5-HT7, α1-adrenergic, α2-adrenergic, and H1 receptor antagonist [8]
- Iloperidone (HP-873, ILO-522; Fanapt, Fiapta, Zomaril) – atypical antipsychotic / 5-HT2A, 5-HT6, 5-HT7, D2, D3, D4, and α1-adrenergic receptor antagonist [9]
- MDMA (Midomafetamine, 3,4-methylenedioxymethamphetamine, "ecstasy") – serotonin–norepinephrine–dopamine releasing agent and 5-HT1 and 5-HT2 receptor agonist – specifically under development as an aid to psychotherapy for post-traumatic stress disorder [10][3][4]
- NBTX-001 (Xenon) – NMDA receptor antagonist [11]
- Pomaglumetad methionil (DB-103, LY-2140023) – mGluR2 and mGluR3 agonist [12]
- Tianeptine oxalate/naloxone (TNX-601) – atypical μ-opioid receptor agonist [13]
Social anxiety disorder
- Fasedienol (Aloradine; PH94B; 4-androstadienol) – vomeropherine / neurosteroid[14]
- JNJ-42165279 – FAAH inhibitor[5][6]
- TGW00AA (FKW00GA) – 5-HT1A receptor agonist, 5-HT2A receptor antagonist [15]
Others/unspecified
- AVN-101 – 5-HT6 receptor antagonist [16]
- BNC-210 (IW-2143) – "GABA modulator"[1] / undefined mechanism of action / α7 subunit-containing nicotinic acetylcholine receptor antagonist[2][17]
- Deuterated etifoxine (GRX-917) – translocator protein (TSPO) agonist and GABAA receptor positive allosteric modulator[18][7]
- JNJ-42165279 – FAAH inhibitor[19]
- JNJ-61393215 – orexin OX1 receptor antagonist [20]
- MP-20X – CB1 and 5-HT1A receptor modulator [21]
- SRX-246 – vasopressin V1A receptor antagonist [22]
See also
References
- ↑ 1.0 1.1 Garakani, Amir; Murrough, James W.; Iosifescu, Dan V. (2014). "Advances in Psychopharmacology for Anxiety Disorders". FOCUS 12 (2): 152–162. doi:10.1176/appi.focus.12.2.152. ISSN 1541-4094.
- ↑ 2.0 2.1 Doggrell, S. A. (2007). Novel drugs and products in neuroscience. Drugs of the Future, 32(11), 1007-1017. https://journals.prous.com/journals/servlet/xmlxsl/pk_journals.xml_summary_pr?p_JournalId=2&p_RefId=3853&p_IsPs=Y
- ↑ "MDMA and PTSD treatment: "PTSD: From novel pathophysiology to innovative therapeutics"". Neurosci. Lett. 649: 176–180. 2017. doi:10.1016/j.neulet.2016.07.004. PMID 27394687.
- ↑ Philipps, Dave (29 November 2016). "F.D.A. Agrees to New Trials for Ecstasy as Relief for PTSD Patients". The New York Times. https://www.nytimes.com/2016/11/29/us/ptsd-mdma-ecstasy.html.
- ↑ "JNJ 42165279 - AdisInsight". https://adisinsight.springer.com/drugs/800036911.
- ↑ "A Safety and Efficacy Study of JNJ-42165279 in Participants With Social Anxiety Disorder | Clinical Research Trial Listing ( Claustrophobia ) ( NCT02432703 )". https://www.centerwatch.com/clinical-trials/listings/72570/phobic-disorders-safety-efficacy-study-jnj-42165279/.
- ↑ "Neurosteroids and translocator protein 18 kDa (TSPO) in depression: implications for synaptic plasticity, cognition, and treatment options". Eur Arch Psychiatry Clin Neurosci 273 (7): 1477–1487. December 2022. doi:10.1007/s00406-022-01532-3. PMID 36574032.
External links
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