List of opioids

Short description: None

This is a list of opioids, opioid antagonists and inverse agonists.

Opium and poppy straw derivatives

Crude opiate extracts whole opium products

B&O Supprettes
Diascordium
Dover's powder
Kendal Black Drop
Laudanum
Mithridate
Opium
Polish heroin (Compote, Kompot)
Paregoric
Poppy straw concentrate
Poppy tea
Smoking opium
Theriac

Natural opiates

Opium alkaloids

Structures

Morphides
Codeine	Morphine	Oripavine	Pseudomorphine	Thebaine

Alkaloid salts mixtures

Pantopon
Papaveretum (Omnopon)
Tetrapon

Semisynthetics including Bentley compounds

Morphine family

14-Hydroxymorphine ^[1]
2,4-Dinitrophenylmorphine
6-Methyldihydromorphine ^[2]
6-Methylenedihydrodesoxymorphine
6-Acetyldihydromorphine ^[3]
Azidomorphine
Chlornaltrexamine
Chloroxymorphamine ^[4]
Desomorphine (dihydrodesoxymorphine)
Dihydromorphine
Ethyldihydromorphine ^[5]^{[full citation needed]}
Hydromorphinol
Methyldesorphine
Morphine methylbromide
N-Phenethylnordesomorphine
N-Phenethyl-14-ethoxymetopon
N-Phenethylnormorphine
6-Nicotinoyldihydromorphine (metabolite of nicodicodeine)
RAM-378
Ro-1539

Structures of Morphine family

Morphine family
14-Hydroxymorphine	2,4-Dinitrophenylmorphine	6-Methyldihydromorphine	6-Methylenedihydrodesoxymorphine	6-Acetyldihydromorphine hydrochloride
Azidomorphine	Chlornaltrexamine	Chloroxymorphamine	Desomorphine (Dihydrodesoxymorphine)	Dihydromorphine
Ethyldihydromorphine	Hydromorphinol	Methyldesorphine	N-Phenethylnormorphine	6-nicotinoyldihydromorphine
RAM-378

3,6-diesters of morphine

Acetylpropionylmorphine
3,6-Dibutanoylmorphine
Diacetyldihydromorphine (dihydroheroin, acetylmorphinol)
Dibutyrylmorphine [1]
Dibenzoylmorphine (first designer drug)
Diformylmorphine
Dipropanoylmorphine
Heroin (diacetylmorphine)
Nicomorphine

Structures

3,6-diesters of morphine
Acetylpropionylmorphine	3,6-Dibutanoylmorphine	Diacetyldihydromorphine (dihydroheroin, acetylmorphinol)
Dibutyrylmorphine	Dibenzoylmorphine	Diformylmorphine
Dipropanoylmorphine	Heroin (diacetylmorphine)	Nicomorphine

Codeine-dionine family

6-Monoacetylcodeine
Benzylmorphine
Codeine methylbromide
Desocodeine [2] ^{[yes|permanent dead link|dead link}}]}
Dimethylmorphine (6-O-Methylcodeine)
Ethyldihydromorphine [3] ^{[yes|permanent dead link|dead link}}]}
Methyldihydromorphine (dihydroheterocodeine)
Ethylmorphine (dionine)
Heterocodeine
Isocodeine [4]
Pholcodine (morpholinylethylmorphine)
Myrophine
Thebacon
Transisocodeine [5]

Structures

Codeine-dionine family
6-Monoacetylcodeine	Benzylmorphine	Codeine methylbromide	Desocodeine	Dimethylmorphine (6-O-Methylcodeine)
Ethyldihydromorphine	Methyldihydromorphine (dihydroheterocodeine)	Ethylmorphine	Heterocodeine	Isocodeine
Pholcodine	Myrophine	Transisocodeine

Morphinones and morphols

14-Cinnamoyloxycodeinone
14-Ethoxymetopon
14-Methoxymetopon
14-Phenylpropoxymetopon
3-Acetyloxymorphone
3,14-Diacetyloxymorphone
7-Spiroindanyloxymorphone
8,14-Dihydroxydihydromorphinone [6]
Acetylcodone
Acetylmorphone
α-hydrocodol (=dihydrocodeine, )
Benzhydrocodone
Bromoisopropropyldihydromorphinone cas?
Codeinone
Codoxime
Conorfone (codorphone)
IBNtxA
Thebacon (acetyldihydrocodeinone, dihydrocodeinone enol acetate)
Hydrocodone
Hydromorphone
Hydroxycodeine [7]
Metopon (=methyldihydromorphinone)
Morphenol [8]
Morphinone
Morphol [9]
N-Phenethyl-14-ethoxymetopon
Noroxymorphone
Oxycodone
Oxymorphol
Oxymorphone
Pentamorphone
Semorphone

Structures

Morphinones and morphols
14-Cinnamoyloxycodeinone	14-Ethoxymetopon	14-Methoxymetopon	14-Phenylpropoxymetopon	7-Spiroindanyloxymorphone
8,14-Dihydroxydihydromorphinone	Acetylcodone	Acetylmorphone	α-hydrocodol (Dihydrocodeine)	Bromoisopropropyldihydromorphinone
Codeinone	Codorphone	Codol (Codeine Phosphate)	Codoxime	IBNtxA
Thebacon	Hydrocodone	Hydromorphone	Hydroxycodeine	Metopon (methyldihydromorphinone)
Morphenol	Morphinone	Morphol	N-Phenethyl-14-ethoxymetopon	Oxycodone
Oxymorphol	Oxymorphone	Pentamorphone	Semorphone

Morphides

α-Chlorocodide (= chlorocodide) [10]
β-Chlorocodide [11]
α-Chloromorphide (= chloromorphide)
Bromocodide [12]
Bromomorphide [13]
Chlorodihydrocodide [14]
Chloromorphide
Codide [15]

Structures

Morphides
α-chlorocodide	β-chlorocodide	Bromomorphide
Chlorodihydrocodide.	Chloromorphide	Codide

Dihydrocodeine series

Structures

Morphides
14-Hydroxydihydrocodeine	Acetyldihydrocodeine	Dihydrocodeine	Dihydrodesoxycodeine
Dihydroisocodeine	Nicocodeine	Nicodicodeine

Nitrogen morphine derivatives

Structures

Morphides
1-Nitrocodeine	Codeine-N-oxide	Morphine-N-oxide

Hydrazones

Oxymorphazone

Structures

Hydrazones
Oxymorphazone

Halogenated morphine derivatives

1-Bromocodeine
1-Chlorocodeine
1-Iodomorphine

Structures

Other open chain opioids
1-Bromocodeine	1-Chlorocodeine	1-Iodomorphine

Active opiate metabolites

Codeine-6-glucuronide
Codeine-N-oxide (genocodeine)[18]
Heroin-7,8-oxide [19]
Morphine-6-glucuronide
3-Monoacetylmorphine
6-Monoacetylmorphine
Morphine-N-oxide (genomorphine)
Naltrexol [20]
Norcodeine
Normorphine

Structures

Active opiate metabolites
Codeine-N-oxide	Heroin-7,8-oxide	Morphine-6-glucuronide	6-Monoacetylmorphine
Morphine-N-oxide	Naltrexol	Norcodeine	Normorphine

Morphinans

Morphinan series

3-Hydroxymorphinan
4-Chlorophenylpyridomorphinan [21]
Cyclorphan
Levargorphan [22]
Levorphanol
Levophenacylmorphan
Levomethorphan
Methorphan (racemethorphan)
Morphanol (racemorphanol)
Norlevorphanol
N-Methylmorphinan [23]
Oxilorphan
Phenomorphan
Proxorphan
Ro4-1539
Stephodeline [24] ^{[yes|permanent dead link|dead link}}]}Xorphanol

Structures

Other morphinans
4-chlorophenylpyridomorphinan	Cyclorphan	Dextrallorphan	Levargorphan	Levophenacylmorphan
Levomethorphan	Norlevorphanol	N-Methylmorphinan	Oxilorphan	Phenomorphan
Dextromethorphan 70 px\|Chemical structure of Levomethorphan. levomethorphan	Morphanol	Ro4-1539	Stephodeline	Xorphanol

Others

1-Nitroaknadinine * 14-episinomenine
5,6-Dihydronorsalutaridine
6-Keto Nalbuphine
Aknadinine
Butorphanol
Cephakicine
Cephasamine
Cyprodime
Drotebanol
Fenfangjine G
Ketorfanol
Nalbuphine
Nalbuphone
Tannagine

Structures

Other Morphinans
1-Nitroaknadinine	14-episinomenine	5,6-Dihydronorsalutaridine	6-Keto Nalbuphine	Aknadinine
Butorphanol	Cephakicine	Cephasamine	Cyprodime	Drotebanol
Fenfangjine G	Nalbuphine	Sinococuline	Sinomenine	Tannagine

Benzomorphans

5,9 alpha-diethyl-2-hydroxybenzomorphan (5,9-DEHB) [25]
8-Carboxamidocyclazocine (8-CAC)
Alazocine
Anazocine [26]
Bremazocine
Butinazocine [27]
Carbazocine [28]
Cogazocine
Cyclazocine
Dezocine
Eptazocine
Etazocine [29] ^{[yes|permanent dead link|dead link}}]}
Ethylketazocine [30]
Fedotozine
Fluorophen [31]
Gemazocine [32] ^{[yes|permanent dead link|dead link}}]}
Ibazocine [33] ^{[yes|permanent dead link|dead link}}]}
Ketazocine
Metazocine
Moxazocine [34]
Pentazocine
Phenazocine
Quadazocine [35]
SKF-10047

[36]-->

Structures

Benzomorphans
5,9 alpha-diethyl-2-hydroxybenzomorphan (5,9-DEHB)	8-Carboxamidocyclazocine	Alazocine	Anazocine	Bremazocine
Butinazocine	Carbazocine	Cogazocine	Cyclazocine	Dezocine
Eptazocine	Etazocine	Ethylketocyclazocine	Fedotozine	Fluorophen
Gemazocine	Ibazocine	Ketazocine	Metazocine	Moxazocine
Pentazocine	Phenazocine	Quadazocine	Thiazocine	Tonazocine
Volazocine	Zenazocine

4-Phenylpiperidines

Pethidines (meperidines)

4-Fluoropethidine
Allylnorpethidine
Anileridine
Benzethidine
Carperidine
Difenoxin
Diphenoxylate
Etoxeridine (carbetidine)
Furethidine
Hydroxypethidine (bemidone)
Morpheridine
Meperidine-N-oxide
Oxpheneridine (carbamethidine)
Pethidine (meperidine)
Pethidine intermediate A
Pethidine intermediate B (norpethidine)
Pethidine intermediate C (pethidinic acid)
Pheneridine
Phenoperidine
Piminodine
Properidine (ipropethidine)
Sameridine

Structures

Pethidines (meperidines)
4-Fluoropethidine	8-Carboxamidocyclazocine	Allylnorpethidine	Anileridine	Benzethidine
Carperidine	Difenoxin	Diphenoxylate	Etoxeridine	Furethidine
Hydroxypethidine	Morpheridine	Meperidine-N-oxide	Oxpheneridine	Pethidine
Pethidine intermediate A	Pethidine intermediate B	Pethidine intermediate C	Pheneridine	Phenoperidine
Piminodine	Properidine	Sameridine

Prodines

Structures

Prodines
Allylprodine	(α/β)-Meprodine	Desmethylprodine (MPPP)	PEPAP	Prodine
Prosidol	Prosidol

Ketobemidones

Structures

Ketobemidones
Acetoxyketobemidone	Droxypropine	Ketobemidone	Methylketobemidone	Propylketobemidone

Others

Structures

Other phenylpiperidines
Alvimopan	Loperamide	LS-115509	Picenadol

Open chain opioids

Amidones

Structures

Amidones
Dextromethadone	Dipipanone	Isomethadone	Levoisomethadone
Noracetylmethadol	Levomethadone	Methadone	Methadone intermediate
Normethadone	Norpipanone	Phenadoxone	Pipidone

Methadols

Structures

Other open chain opioids
Alphaacetylmethadol	Dimepheptanol	Levacetylmethadol	Noracetylmethadol

Moramides

Structures

Other open chain opioids
Desmethylmoramide	Dextromoramide	Levomoramide	Moramide intermediate	Racemoramide

Thiambutenes

Structures

Thiambutenes
Diethylthiambutene	Dimethylthiambutene	Ethylmethylthiambutene
Piperidylthiambutene	Thiambutene	Tipepidine

Phenalkoxams

Structures

Phenalkoxams
Error creating thumbnail: Unable to save thumbnail to destination Dextropropoxyphene (propoxyphene)	Dimenoxadol	Dioxaphetyl butyrate	Levopropoxyphene	Norpropoxyphene

Ampromides

Structures

Ampromides
Diampromide	Phenampromide	Propiram

Others

Structures

Other open chain opioids
Embutramide	IC-26	Isoaminile	Lefetamine	R-4066

Anilidopiperidines

Structures

Anilidopiperidines
3-Allylfentanyl	3-Methylfentanyl	3-Methylthiofentanyl	4-Phenylfentanyl	Alfentanil
Alphamethylacetylfentanyl	Alphamethylfentanyl	Alphamethylthiofentanyl	Benzylfentanyl	Betahydroxyfentanyl
Betahydroxythiofentanyl	Betamethylfentanyl	Brifentanil	Carfentanil	Fentanyl
Lofentanil	Mirfentanil	Ocfentanil	Ohmefentanyl	Parafluorofentanyl
Phenaridine	Remifentanil	Sufentanil	Thenylfentanyl	Thiofentanyl
Trefentanil

Oripavine derivatives

7-PET
Acetorphine
Alletorphine (N-allyl-noretorphine)
BU-48
Buprenorphine
Buprenorphine-3-glucuronide
Cyprenorphine
Dihydroetorphine
Etorphine
Homprenorphine
18,19-Dehydrobuprenorphine (HS-599) [43] [44]
N-cyclopropylmethylnoretorphine [45]
Nepenthone [46] [47]
Norbuprenorphine
Norbuprenorphine-3-glucuronide
Thevinone [48]
Thienorphine [49]

Structures

Oripavine derivatives
7-PET	Acetorphine	Alletorphine	BU-48	Buprenorphine
Cyprenorphine	Dihydroetorphine	Etorphine	Homprenorphine	18,19-Dehydrobuprenorphine
N-cyclopropylmethylnoretorphine	Nepenthone	Norbuprenorphine	Thevinone	Thienorphine

Phenazepanes

Structures

Phenazepanes
Ethoheptazine	Meptazinol	Metheptazine	Metethoheptazine	Proheptazine

Pirinitramides

Structures

Pirinitramides
Bezitramide	Piritramide

Benzimidazoles

Structures

Benzimidazoles
Clonitazene	Etonitazene	Isotonitazene	Metonitazene	Nitazene: R = hydrogen

Indoles

Structures

Indoles
18-Methoxycoronaridine	7-Acetoxymitragynine	7-Hydroxymitragynine	Akuammidine	Akuammine
Eseroline	Hodgkinsine	Mitragynine	Pericine	Pseudoakuammigine

Beta-Amino Ketones

3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one

Structures

	Indoles
3-(dimethylamino)-2,2-dimethyl-1-phenylpropan-1-one (Beta-amine ketone 'compound 29')

Diphenylmethylpiperazines

Structures

Diphenylmethylpiperazines
BW373U86	DPI-221	DPI-287	DPI-3290	SNC-80

Opioid peptides

Dynorphins

Structures

Dynorphins
Big dynorphin	Dynorphin A	Error creating thumbnail: Unable to save thumbnail to destination Dynorphin B

Endomorphins

Endorphins

α-Endorphin
β-Endorphin
γ-Endorphin
α-Neoendorphin
β-Neoendorphin

Structures

Dynorphins
Beta-endorphin	Alpha-endorphin	Gamma-endorphin	α-neoendorphin	β-neoendorphin

Enkephalins

Structures

Enkephalins
DADLE	DAMGO	Deltorphin	Met-enkephalin	Leu-enkephalin

Propeptides

Others / unknown

Structures

Other or unknown opioid peptides
Adrenorphin	Amidorphin	Casomorphin	DALDA	Deltorphin
Dermorphin	DPDPE	Endomorphin-1 135 px\|Chemical structure of Endomorphin-2. Endomorphin-2	Gliadorphin	Morphiceptin
Nociceptin	Octreotide	Opiorphin	Rubiscolin	TRIMU 5

Others

3-(3-Methoxyphenyl)-3-ethoxycarbonyltropane
AD-1211
AH-7921
Axomadol
Azaprocin
BDPC
Bisnortilidine [51] [52]
BRL-52537
Bromadol
Bromadoline
Ciprefadol
Ciramadol
Doxpicomine
Enadoline
Faxeladol
GR-89696
Herkinorin
ICI-199,441
ICI-204,448
Ketamine
KNT-42
LPK-26
Lufuradom
Metofoline
MT-45
Desmethylclozapine
Nexeridine
NNC 63-0532
Nortilidine
O-Desmethyltramadol
Phenadone
Phencyclidine
Prodilidine
Profadol
Ro64-6198
Salvinorin A
Salvinorin B ethoxymethyl ether
Salvinorin B methoxymethyl ether
SB-612,111
SC-17599
RWJ-394,674
TAN-67
Tapentadol
Thiobromadol (C-8813)
Tifluadom
Tilidine
Tramadol
Trimebutine
U-47700
U-50,488
U-69,593
Viminol
1-(4-Nitrophenylethyl)piperidylidene-2-(4-chlorophenyl)sulfonamide (W-18)

Opioid antagonists and inverse agonists

4-Caffeoyl-1,5-quinide
5'-Guanidinonaltrindole
β-Funaltrexamine
6β-Naltrexol
6β-Naltrexol-d4
Alvimopan
AT-076
Binaltorphimine
BU09059
Buprenorphine
Chlornaltrexamine
Clocinnamox
Cyclazocine
Cyprodime
Diacetylnalorphine [53]
Diprenorphine (M5050)
Fedotozine
ICI-174864
J-113,397
JDTic
JTC-801
Levallorphan
LY-2456302
LY-255582
Methocinnamox
Methylnaltrexone
ML350
Naldemedine
Nalfurafine
Nalmefene
Nalmexone [54]
Nalodeine (N-allylnorcodeine) [55]
Naloxazone
Naloxegol
Naloxol
Naloxonazine
Naloxone
Naloxone benzoylhydrazone
Nalorphine
Naltrexone
Naltriben
Naltrindole
Norbinaltorphimine
Oxilorphan
PF-4455242
S-allyl-3-hydroxy-17-thioniamorphinan (SAHTM)[56]
Samidorphan
SR-16430

Biased ligands

Receptor heteromer targeting ligands

6'-GNTI (δ-κ)
CYM-51010 (δ-μ)^[6]
NNTA (κ-μ)^[7]
IBNtxA (μ1G-NOP)

Uncategorized opioids

Structures

Uncategorized opioids
Alimadol	Anilopam	Asimadoline
FE 200665	Fedotozine	MCOPPB
Nalfurafine	Nalodeine	Nalorphine	Nalorphine dinicotinate
SoRI-9409

Combination drug formulations containing opioids

Buprenorphine/naloxone
Buprenorphine/samidorphan (ALKS-5461)
Co-codamol (codeine phosphate/paracetamol)
Co-codaprin (codeine phosphate/aspirin)
Co-dydramol (dihydrocodeine tartrate/paracetamol)
Co-proxamol (dextropropoxyphene/paracetamol)
Fentanyl/fluanisone
Hydrocodone/ibuprofen
Hydrocodone/paracetamol
Loperamide/simethicone
Morphine/naltrexone
Naltrexone/bupropion
Oxycodone/aspirin
Oxycodone/naloxone
Oxycodone/paracetamol

References

↑ ChemIndex CAS Registry Number 3371-56-0
↑ ChemIndex CAS Registry Number 509-56-8
↑ ChemIndex CAS Registry Number 63715-94-6
↑ NCBI PubChem SID 750205
↑ chembase ^{[yes|permanent dead link|dead link}}]} cbid_346222
↑ "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. 2013. doi:10.1073/pnas.1222044110. PMID 23818586. Bibcode: 2013PNAS..11012072G.
↑ "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. 2011. doi:10.1073/pnas.1016277108. PMID 21385944. Bibcode: 2011PNAS..108.5098Y.

External links

Carbonate derivatives of 14β-hydroxycodeine "viz., 14β-hydroxy-6-O-(methoxycarbonyl)codeine, 6-O-methoxycarbonyl-14β-(methoxycarbonyloxy)codeine, and 14β-acetoxy-6-O-methoxy-carbonylcodeine, potential substrates for ring C modification in morphinane (sic) alkaloids, were synthesized for the first time." Russian Chemical Bulletin. August 2008, Volume 57, Issue 8, pp 1773–1774. Date: 11 Aug 2009; I. V. Evsikova, S. K. Moiseev, P. V. Petrovskii, V. N. Kalinin. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 8, pp. 1739–1740

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Original source: https://en.wikipedia.org/wiki/List of opioids. Read more

[1] ChemIndex CAS Registry Number 3371-56-0

[2] ChemIndex CAS Registry Number 509-56-8

[3] ChemIndex CAS Registry Number 63715-94-6

[4] NCBI PubChem SID 750205

[5] se ^{[yes|permanent dead link|dead link}}]} cbid_346222

[pmid23818586-6] "Identification of a μ-δ opioid receptor heteromer-biased agonist with antinociceptive activity". Proc. Natl. Acad. Sci. U.S.A. 110 (29): 12072–7. 2013. doi:10.1073/pnas.1222044110. PMID 23818586. Bibcode: 2013PNAS..11012072G.

[pmid21385944-7] "N-naphthoyl-beta-naltrexamine (NNTA), a highly selective and potent activator of μ/kappa-opioid heteromers". Proc. Natl. Acad. Sci. U.S.A. 108 (12): 5098–103. 2011. doi:10.1073/pnas.1016277108. PMID 21385944. Bibcode: 2011PNAS..108.5098Y.

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[7]

v t e Opioid receptor modulators
MOR	Agonists (abridged; see here for a full list): 3-HO-PCP 7-Acetoxymitragynine 7-Hydroxymitragynine ψ-Akuammigine α-Chlornaltrexamine α-Narcotine Acetyldihydrocodeine Acetylfentanyl Acrylfentanyl Adrenorphin (metorphamide) AH-7921 Akuammicine Akuammidine Alfentanil Anileridine Apparicine β-Endorphin BAM-12P BAM-18P BAM-22P Benzhydrocodone Benzylmorphine Bezitramide Biphalin BU08070 Buprenorphine Butorphan Butorphanol Butyrfentanyl BW373U86 Carfentanil Casokefamide Cebranopadol Chloroxymorphamine Codeine DADLE DAMGO (DAGO) Dermorphin Desmetramadol (desmethyltramadol) Desomorphine Dextromoramide Dextropropoxyphene (propoxyphene) Dezocine Dimenoxadol Dimethylaminopivalophenone Eluxadoline Diamorphine (heroin) Dihydrocodeine Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diphenoxylate Dipipanone Dynorphin A Embutramide Endomorphin-1 Endomorphin-2 Eseroline Ethylmorphine Etorphine Fentanyl Fluorophen Frakefamide Furanylfentanyl Hemorphin-4 Herkinorin Hodgkinsine Hydrocodone Hydromorphinol Hydromorphone IBNtxA Ketamine Ketobemidone Kratom Laudanosine Lefetamine Leu-enkephalin Levacetylmethadol Levomethorphan Levorphanol Lexanopadol Loperamide Loxicodegol Matrine Meptazinol Met-enkephalin (metenkefalin) Methadone Metkefamide Metopon Mitragynine Mitragynine pseudoindoxyl Morphiceptin Morphine Nalbuphine NalBzOH Nalmexone Naltalimide Neopine NFEPP Nicocodeine Nicodicodine Nicomorphine NKTR-181 Norketamine Octreotide Oliceridine OM-3-MNZ Oripavine Oxycodone Oxymorphazone Oxymorphonazine Oxymorphone Oxymorphone phenylhydrazone OxyPNPH Papaver somniferum (opium) Pentazocine Pericine Pethidine (meperidine) Phenazocine Phencyclidine Piminodine Piritramide PL-017 Prodine Propiram PZM21 Racemethorphan Racemorphan Remifentanil Salsolinol SC-17599 Sinomenine Sufentanil Tapentadol Tetrahydropapaveroline TH-030418 Thebaine Thienorphine Tianeptine Tilidine Tramadol Trimebutine TRIMU 5 TRV734 Tubotaiwine U-47700 Valorphin Viminol Xorphanol PAMs: BMS-986121 BMS-986122 Antagonists: (3S,4S)-Picenadol 2-(S)-N,N-(R)-Viminol 3CS-nalmefene 4-Caffeoyl-1,5-quinide 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 6β-Naltrexol 6β-Naltrexol-d4 18-MC α-Gliadin β-Chlornaltrexamine β-Funaltrexamine Akuammine Alvimopan AM-251 Apigenin AT-076 Axelopran Bevenopran Catechin Catechin gallate Clocinnamox CTAP CTOP Cyclofoxy Cyprodime Diacetylnalorphine Diprenorphine ECG EGC Epicatechin Eptazocine Gemazocine Ginsenoside R Hyperoside Ibogaine Levallorphan Lobeline LY-255582 LY-2196044 Methocinnamox Methylnaltrexone Methylsamidorphan chloride Naldemedine Nalmefene Nalodeine (N-allylnorcodeine) Nalorphine Nalorphine dinicotinate Naloxazone Naloxegol Naloxol Naloxonazine Naloxone Naltrexazone Naltrexonazine Naltrexone Naltrindole Naringenin Noribogaine Oxilorphan Pawhuskin A Rimonabant Quadazocine Samidorphan Taxifolin Unknown/unsorted: Cannabidiol Coronaridine Cyproterone acetate Dihydroakuuamine Tabernanthine Tetrahydrocannabinol
DOR	Agonists: 3CS-nalmefene 6'-GNTI 7-SIOM ADL-5747 (PF-04856881) ADL-5859 Alazocine (SKF-10047) Amoxapine AR-M100390 (ARM390) AZD2327 β-Endorphin BAM-18P Biphalin BU-48 Butorphan Butorphanol BW373U86 Casokefamide Cebranopadol Codeine Cyclazocine DADLE Deltorphin A Deltorphin I Deltorphin II Desmethylclozapine Desmetramadol (desmethyltramadol) Dezocine Diamorphine (heroin) Dihydroetorphine Dihydromorphine DPDPE DPI-221 DPI-3290 DSLET Ethylketazocine Etorphine Fentanyl FIT Fluorophen Hemorphin-4 Hydrocodone Hydromorphone Ibogaine Isomethadone JNJ-20788560 KNT-127 Kratom Laudanosine Leu-enkephalin Levomethorphan Levorphanol Lexanopadol Lofentanil Met-enkephalin (metenkefalin) Metazocine Metkefamide Mitragynine Mitragynine pseudoindoxyl Morphine N-Phenethyl-14-ethoxymetopon Norbuprenorphine NalBzOH Oripavine Oxycodone Oxymorphone Pethidine (meperidine) Proglumide Racemethorphan Racemorphan RWJ-394674 Samidorphan SB-235863 SNC-80 SNC-162 TAN-67 (SB-205,607) TH-030418 Thebaine Thiobromadol (C-8813) Tonazocine Tramadol TRV250 Xorphanol Zenazocine Antagonists: 4',7-Dihydroxyflavone 5'-NTII 6β-Naltrexol 6β-Naltrexol-d4 α-Santolol β-Chlornaltrexamine Apigenin AT-076 Axelopran Bevenopran BNTX Catechin Catechin gallate Clocinnamox Diacetylnalorphine Diprenorphine ECG EGC Eluxadoline Epicatechin ICI-154129 ICI-174864 LY-255582 LY-2196044 Methylnaltrexone Methylnaltrindole N-Benzylnaltrindole Nalmefene Nalorphine Naltrexone Naltriben Naltrindole Naloxone Naringenin Noribogaine Pawhuskin A Quadazocine SDM25N SoRI-9409 Taxifolin Thienorphine Unknown/unsorted: 18-MC Cannabidiol Coronaridine Cyproterone acetate Tabernanthine Tetrahydrocannabinol
KOR	Agonists: 3CS-nalmefene 6'-GNTI 8-CAC 18-MC 14-Methoxymetopon β-Chlornaltrexamine β-Funaltrexamine Adrenorphin (metorphamide) Akuuamicine Alazocine (SKF-10047) Allomatrine Apadoline Asimadoline BAM-12P BAM-18P BAM-22P Big dynorphin Bremazocine BRL-52537 Butorphan Butorphanol BW373U86 Cebranopadol Ciprefadol CR665 Cyclazocine Cyclorphan Cyprenorphine Desmetramadol (desmethyltramadol) Diamorphine (heroin) Diacetylnalorphine Difelikefalin Dihydroetorphine Dihydromorphine Dinalbuphine sebacate Diprenorphine Dynorphin A Dynorphin B (rimorphin) Eluxadoline Enadoline Eptazocine Erinacine E Ethylketazocine Etorphine Fedotozine Fentanyl Gemazocine GR-89696 GR-103545 Hemorphin-4 Herkinorin HS665 Hydromorphone HZ-2 Ibogaine ICI-199,441 ICI-204,448 Ketamine Ketazocine Laudanosine Leumorphin (dynorphin B-29) Levallorphan Levomethorphan Levorphanol Lexanopadol Lofentanil LPK-26 Lufuradom Matrine MB-1C-OH Menthol Metazocine Metkefamide Mianserin Mirtazapine Morphine Moxazocine MR-2034 N-MPPP Nalbuphine NalBzOH Nalfurafine Nalmefene Nalodeine (N-allylnorcodeine) Nalorphine Naltriben Niravoline Norbuprenorphine Norbuprenorphine-3-glucuronide Noribogaine Norketamine Oripavine Oxilorphan Oxycodone Pentazocine Pethidine (meperidine) Phenazocine Proxorphan Racemethorphan Racemorphan RB-64 Salvinorin A (salvia) Salvinorin B ethoxymethyl ether Salvinorin B methoxymethyl ether Samidorphan Spiradoline (U-62,066) TH-030418 Thienorphine Tifluadom Tricyclic antidepressants (e.g., amitriptyline, desipramine, imipramine, nortriptyline) U-50488 U-54,494A U-69,593 Xorphanol Antagonists: 4′-Hydroxyflavanone 4',7-Dihydroxyflavone 5'-GNTI 6'-GNTI 6β-Naltrexol 6β-Naltrexol-d4 β-Chlornaltrexamine Buprenorphine/samidorphan Amentoflavone ANTI Apigenin Arodyne AT-076 Aticaprant Axelopran AZ-MTAB Binaltorphimine BU09059 Buprenorphine Catechin Catechin gallate CERC-501 (LY-2456302) Clocinnamox Cyclofoxy Dezocine DIPPA EGC ECG Epicatechin Hyperoside JDTic LY-255582 LY-2196044 LY-2444296 LY-2459989 LY-2795050 MeJDTic Methylnaltrexone ML190 ML350 MR-2266 N-Fluoropropyl-JDTic Naloxone Naltrexone Naltrindole Naringenin Norbinaltorphimine Noribogaine Pawhuskin A PF-4455242 RB-64 Quadazocine Taxifolin UPHIT Zyklophin Unknown/unsorted: Akuammicine Akuammine Coronaridine Cyproterone acetate Dihydroakuuamine Ibogamine Tabernanthine
NOP	Agonists: (Arg14,Lys15)Nociceptin ((pF)Phe⁴)Nociceptin(1-13)NH₂ (Phe¹Ψ(CH₂-NH)Gly²)Nociceptin(1-13)NH₂ Ac-RYYRWK-NH₂ Ac-RYYRIK-NH₂ BU08070 Buprenorphine Cebranopadol Dihydroetorphine Etorphine JNJ-19385899 Levomethorphan Levorphanol Levorphanol Lexanopadol MCOPPB MT-7716 NNC 63-0532 Nociceptin (orphanin FQ) Nociceptin (1-11) Nociceptin (1-13)NH₂ Norbuprenorphine Racemethorphan Racemorphan Ro64-6198 Ro65-6570 SCH-221510 SCH-486757 SR-8993 SR-16435 TH-030418 Antagonists: (Nphe¹)Nociceptin(1-13)NH₂ AT-076 BAN-ORL-24 BTRX-246040 (LY-2940094) J-113,397 JTC-801 NalBzOH Nociceptin (1-7) Nocistatin SB-612,111 SR-16430 Thienorphine Trap-101 UFP-101
Unsorted	β-Casomorphins Amidorphin BAM-20P Cytochrophin-4 Deprolorphin Gliadorphin (gluteomorphin) Gluten exorphins Hemorphins Kava constituents MEAGL MEAP NEM Neoendorphins Nepetalactone (catnip) Peptide B Peptide E Peptide F Peptide I Rubiscolins Soymorphins
Others	Enkephalinase inhibitors: Amastatin BL-2401 Candoxatril D -Phenylalanine Dexecadotril (retorphan) Ecadotril (sinorphan) Kelatorphan Racecadotril (acetorphan) RB-101 RB-120 RB-3007 Opiorphan Selank Semax Spinorphin Thiorphan Tynorphin Ubenimex (bestatin) Propeptides: β-Lipotropin (proendorphin) Prodynorphin Proenkephalin Pronociceptin Proopiomelanocortin (POMC) Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
See also: Receptor/signaling modulators • Signaling peptide/protein receptor modulators

List of opioids

Topic: Chemistry

Opium and poppy straw derivatives

Crude opiate extracts whole opium products

Natural opiates

Opium alkaloids

Alkaloid salts mixtures

Semisynthetics including Bentley compounds

Morphine family

3,6-diesters of morphine

Codeine-dionine family

Morphinones and morphols

Morphides

Dihydrocodeine series

Nitrogen morphine derivatives

Hydrazones

Halogenated morphine derivatives

Active opiate metabolites

Morphinan series

Others

Benzomorphans

Pethidines (meperidines)

Others

Open chain opioids

Amidones

Methadols

Moramides

Thiambutenes

Phenalkoxams

Ampromides

Others

Anilidopiperidines

Oripavine derivatives

Phenazepanes

Pirinitramides

Beta-Amino Ketones

Endorphins

Propeptides

Others / unknown

Others

Opioid antagonists and inverse agonists

Receptor heteromer targeting ligands

Uncategorized opioids

Combination drug formulations containing opioids

See also

References

External links