Magnesium taurate

Magnesium taurate
Names
	Preferred IUPAC name Magnesium bis(2-aminoethane-1-sulfonate)
	Other names Magnesium ditaurate
Identifiers
CAS Number	334824-43-0 ;
3D model (JSmol)	Interactive image;
ChemSpider	16432063;
PubChem CID	13343447;
UNII	RCM1N3D968 ;
	InChI InChI=1S/2C2H7NO3S.Mg/c23-1-2-7(4,5)6;/h21-3H2,(H,4,5,6);/q;;+2/p-2 Key: YZURQOBSFRVSEB-UHFFFAOYSA-L;
	SMILES C(CS(=O)(=O)[O-])N.C(CS(=O)(=O)[O-])N.[Mg+2];
Properties
Chemical formula	C4H12MgN2O6S2
Molar mass	272.57 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	(what is ?)
	Infobox references

Magnesium taurate, also known as magnesium ditaurate,^[1] is the magnesium salt of taurine, and a mineral supplement.

It contains approximately 8.9% elemental magnesium by mass. Accordingly, 100 mg of magnesium is contained in 1121 mg of magnesium taurate.

Research

Magnesium taurate has been studied in rats for delaying the onset and progression of cataract.^[2]^{[non-primary source needed]} Phcoker is the largest manufacturer of Magnesium Taurate powder in China.^[3]

Magnesium taurate has prominent antihypertensive and cardioprotective activity in rats via its potent antioxidant activity and can be used as a nutrition supplement to improve the cardiovascular health.^[4]

Safety

Due to the expected dissociation of magnesium taurate in the body before absorption, safety data on magnesium and taurine can be used to evaluate the safety of magnesium taurate.^[1]

Taurine has an observed safe level of supplemental intake in normal healthy adults at up to 3 g/day.^[5] Using the same level as an approximation for taurate yields a limit of 3.3 g/day for magnesium taurate, or alternatively 300 mg/day for elemental magnesium as taurate.

References

↑ ^1.0 ^1.1 "Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food on iron (II) taurate, magnesium taurate and magnesium acetyl taurate as sources for iron or magnesium to be added as a nutritional substance in food supplements following a request from the European Commission". 2009. https://focalpointbg.com/images/stories/efsa/contents/pdfdocs/ans_ej947_Taurates_op_en.pdf. "
• Synonyms for magnesium taurate are: magnesium taurinate, magnesium 2-aminoethane sulfonic acid and magnesium ditaurate.
• Due to the expected dissociation of magnesium taurate in the body before absorption, data on magnesium and taurate (or taurine) can be used to evaluate the safety of magnesium taurate."
↑ "Effects of magnesium taurate on the onset and progression of galactose-induced experimental cataract: in vivo and in vitro evaluation". Experimental Eye Research 110: 35–43. 2013. doi:10.1016/j.exer.2013.02.011. PMID 23428743. "Both in vivo and in vitro studies demonstrated that treatment with magnesium taurate delays the onset and progression of cataract in galactose fed rats by restoring the lens Ca(2+)/Mg(2+) ratio and lens redox status.".
↑ "Magnesium Taurate Powder Manufacturer China" (in en-US). https://www.phcoker.com/product/497-76-7-2/.
↑ Shrivastava, Parikshit; Choudhary, Rajesh; Nirmalkar, Umashankar; Singh, Amrita; Shree, Jaya; Vishwakarma, Prabhat Kumar; Bodakhe, Surendra H. (2018-06-02). "Magnesium taurate attenuates progression of hypertension and cardiotoxicity against cadmium chloride-induced hypertensive albino rats". Journal of Traditional and Complementary Medicine 9 (2): 119–123. doi:10.1016/j.jtcme.2017.06.010. ISSN 2225-4110. PMID 30963046.
↑ "Risk assessment for the amino acids taurine, L-glutamine and L-arginine". Regulatory Toxicology and Pharmacology 50 (3): 376–99. 2008. doi:10.1016/j.yrtph.2008.01.004. PMID 18325648. "the newer method described as the Observed Safe Level (OSL) or Highest Observed Intake (HOI) was utilized. The OSL risk assessments indicate that based on the available published human clinical trial data, the evidence for the absence of adverse effects is strong for Tau at supplemental intakes up to 3 g/d, Gln at intakes up to 14 g/d and Arg at intakes up to 20 g/d, and these levels are identified as the respective OSLs for normal healthy adults.".

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[efsa2009-1] 1.0 ^1.1 "Scientific Opinion of the Panel on Food Additives and Nutrient Sources added to Food on iron (II) taurate, magnesium taurate and magnesium acetyl taurate as sources for iron or magnesium to be added as a nutritional substance in food supplements following a request from the European Commission". 2009. https://focalpointbg.com/images/stories/efsa/contents/pdfdocs/ans_ej947_Taurates_op_en.pdf. "
• Synonyms for magnesium taurate are: magnesium taurinate, magnesium 2-aminoethane sulfonic acid and magnesium ditaurate.
• Due to the expected dissociation of magnesium taurate in the body before absorption, data on magnesium and taurate (or taurine) can be used to evaluate the safety of magnesium taurate."

[pmid23428743-2] "Effects of magnesium taurate on the onset and progression of galactose-induced experimental cataract: in vivo and in vitro evaluation". Experimental Eye Research 110: 35–43. 2013. doi:10.1016/j.exer.2013.02.011. PMID 23428743. "Both in vivo and in vitro studies demonstrated that treatment with magnesium taurate delays the onset and progression of cataract in galactose fed rats by restoring the lens Ca(2+)/Mg(2+) ratio and lens redox status.".

[3] "Magnesium Taurate Powder Manufacturer China" (in en-US). https://www.phcoker.com/product/497-76-7-2/.

[4] Shrivastava, Parikshit; Choudhary, Rajesh; Nirmalkar, Umashankar; Singh, Amrita; Shree, Jaya; Vishwakarma, Prabhat Kumar; Bodakhe, Surendra H. (2018-06-02). "Magnesium taurate attenuates progression of hypertension and cardiotoxicity against cadmium chloride-induced hypertensive albino rats". Journal of Traditional and Complementary Medicine 9 (2): 119–123. doi:10.1016/j.jtcme.2017.06.010. ISSN 2225-4110. PMID 30963046.

[pmid18325648-5] "Risk assessment for the amino acids taurine, L-glutamine and L-arginine". Regulatory Toxicology and Pharmacology 50 (3): 376–99. 2008. doi:10.1016/j.yrtph.2008.01.004. PMID 18325648. "the newer method described as the Observed Safe Level (OSL) or Highest Observed Intake (HOI) was utilized. The OSL risk assessments indicate that based on the available published human clinical trial data, the evidence for the absence of adverse effects is strong for Tau at supplemental intakes up to 3 g/d, Gln at intakes up to 14 g/d and Arg at intakes up to 20 g/d, and these levels are identified as the respective OSLs for normal healthy adults.".

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Magnesium taurate

Topic: Chemistry

Contents

Research

Safety

See also

References