Metixene

Metixene
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	N04AA03 (WHO) ;
Legal status
Legal status	BR: Class C1 (Other controlled substances) ;
Identifiers
	IUPAC name 1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine;
CAS Number	4969-02-2 ;
PubChem CID	4167;
IUPHAR/BPS	7232;
DrugBank	DB00340;
ChemSpider	4023;
UNII	32VY6L26ZW;
KEGG	D08209;
ChEBI	CHEBI:51024;
ChEMBL	ChEMBL1201342;
Chemical and physical data
Formula	C20H23NS
Molar mass	309.47 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN1CCCC(C1)CC2C3=CC=CC=C3SC4=CC=CC=C24;
	InChI InChI=1S/C20H23NS/c1-21-12-6-7-15(14-21)13-18-16-8-2-4-10-19(16)22-20-11-5-3-9-17(18)20/h2-5,8-11,15,18H,6-7,12-14H2,1H3; Key:MJFJKKXQDNNUJF-UHFFFAOYSA-N;
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Short description: Chemical compound

Metixene (brand names Methixart, CholinFall, Tremonil, Trest), also known as methixene, is an anticholinergic used as an antiparkinsonian agent.^[1] It has also been reported to induce incomplete autophagy and cell death in metastatic cancer and brain metastases. ^[2]

References

↑ "Metixene". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. 1999. p. 178. ISBN 978-94-011-4439-1. https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA178.
↑ Fares, Jawad (2023). "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases". Journal of Clinical Investigation. doi:10.1172/JCI161142. PMID 37847564. PMC 10721147. https://www.jci.org/articles/view/161142. Retrieved 3 November 2023.

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[1] "Metixene". Concise Dictionary of Pharmacological Agents: Properties and Synonyms. Dordrecht: Springer Netherlands. 1999. p. 178. ISBN 978-94-011-4439-1. https://books.google.com/books?id=tsjrCAAAQBAJ&pg=PA178.

[2] Fares, Jawad (2023). "Metixene is an incomplete autophagy inducer in preclinical models of metastatic cancer and brain metastases". Journal of Clinical Investigation. doi:10.1172/JCI161142. PMID 37847564. PMC 10721147. https://www.jci.org/articles/view/161142. Retrieved 3 November 2023.

[1]

[2]

Metixene

Topic: Chemistry

See also

References