Miotine

Miotine
Names
	IUPAC name [3-[1-(Dimethylamino)ethyl]phenyl] N-methylcarbamate
Identifiers
CAS Number	4464-16-8 ;
3D model (JSmol)	Interactive image;
ChemSpider	41955 ;
KEGG	C11763 ;
PubChem CID	46093;
UNII	9Z3ZT09RRU ;
	InChI InChI=1S/C12H18N2O2/c1-9(14(3)4)10-6-5-7-11(8-10)16-12(15)13-2/h5-9H,1-4H3,(H,13,15) Key: KQOUPMYYRQWZLI-UHFFFAOYSA-N ; InChI=1/C12H18N2O2/c1-9(14(3)4)10-6-5-7-11(8-10)16-12(15)13-2/h5-9H,1-4H3,(H,13,15) Key: KQOUPMYYRQWZLI-UHFFFAOYAX;
	SMILES CC(C1=CC(=CC=C1)OC(=O)NC)N(C)C;
Properties
Chemical formula	C12H18N2O2
Molar mass	222.288 g·mol−1
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

Miotine is an anticholinesterase drug. Miotine was the first synthetic carbamate that was used clinically.^[1]

Unlike the miotine analog neostigmine, it doesn't have a quaternary ammonium group to give it a permanent positive charge. It can exist as an uncharged free base which could allow it to cross the blood–brain barrier and cause unwanted central nervous system (CNS) side effects.^[2]

References

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Original source: https://en.wikipedia.org/wiki/Miotine. Read more

[1] "Archived copy". http://www.weizmann.ac.il/sb/faculty_pages/Sussman/papers/2002_Bar-On_Biochem.pdf.

[2] "An introduction to drugs,their action and discovery". http://media.wiley.com/product_data/excerpt/72/04700259/0470025972.pdf.

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Miotine

Topic: Chemistry

See also

References