Categories
NS-2710
Topic: Chemistry
From HandWiki - Reading time: 5 min
Short description: Chemical compound
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| Formula | C22H20N4O |
| Molar mass | 356.429 g·mol−1 |
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NS-2710 (LS-193,970) is an anxiolytic drug with a novel chemical structure, developed by the small pharmaceutical company NeuroSearch. It has similar effects to benzodiazepine drugs, but is structurally distinct and so is classed as a nonbenzodiazepine anxiolytic. NS-2710 is a potent but non-selective partial agonist at GABAA receptors, although with little efficacy at the α1 subtype and more at α2 and α3. It has anxiolytic effects comparable to chlordiazepoxide,[1] and while it is a less potent anticonvulsant than the related drug NS-2664, it has a much longer duration of action, and similarly to other α2/α3-preferring partial agonists produces little sedative effects or physical dependence.[2]
References
- ↑ "A comparison of the effects of psychotomimetics and anxiolytics on punished and unpunished responding maintained by fixed interval schedules of food reinforcement in the rat". Behavioural Pharmacology 17 (1): 87–99. February 2006. doi:10.1097/01.fbp.0000189812.77049.e5. PMID 16377966.
- ↑ "Do subtype-selective gamma-aminobutyric acid A receptor modulators have a reduced propensity to induce physical dependence in mice?". The Journal of Pharmacology and Experimental Therapeutics 316 (3): 1378–85. March 2006. doi:10.1124/jpet.105.094474. PMID 16352707.
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