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PX-3

Topic: Chemistry

 From HandWiki - Reading time: 7 min

Short description: Chemical compound
PX-3
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
UNII
Chemical and physical data
FormulaC24H28N4O2
Molar mass404.514 g·mol−1
3D model (JSmol)

PX-3 (also known as APP-CHMINACA) is an indazole-based synthetic cannabinoid. It is a potent agonist of the CB1 receptor with a binding affinity of Ki = 47.6 nM and was originally developed by Pfizer in 2009 as an analgesic medication.[1][2][3][4]

The acronym 'APP' signifies the 'amino', 'phenyl' and 'propanone' elements of the structure. Three related compounds, PX-1 (5F-APP-PICA, SRF-30), PX-2 (5F-APP-PINACA, FU-PX) and APP-FUBINACA were reported by the EMCDDA in late 2014.[5][6]

Legality

Sweden's public health agency suggested to classify APP-CHMINACA as hazardous substance on June 1, 2015.[7]

See also

References

  1. ↑ "APP-CHMINACA". Cayman Chemical. https://www.caymanchem.com/product/17614. 
  2. ↑ "Indazole derivatives" WO patent 2009106980
  3. ↑ "EWS Forum - In Belgien wurde die neue psychoaktive Substanz N-(2-amino-1-benzyl-2-oxo-ethyl)-1-(cyclohexylmethyl)indazole-3-carboxamide (APP-CHMINACA) identifiziert.". https://forum.goeg.at/EwsForum/default.aspx?g=posts&t=211. 
  4. ↑ "In Vitro Metabolic Profile Elucidation of Synthetic Cannabinoid APP-CHMINACA (PX-3)". Journal of Analytical Toxicology 44 (3): 226–236. April 2020. doi:10.1093/jat/bkz086. PMID 31665324. 
  5. ↑ "EWS Forum - In Schweden wurde die neue psychoaktive Substanz N-(1-amino-1-oxo-3-phenylpropan-2-yl)-1-(5-fluoropentyl)-1H-indole-3-carboxamide (5F-APP-PICA) identifiziert.". https://forum.goeg.at/EwsForum/default.aspx?g=posts&t=194. 
  6. ↑ "EWS Forum - In Schweden wurden folgende drei neue psychoaktive Substanzen identifiziert.". https://forum.goeg.at/EwsForum/default.aspx?g=posts&t=193. 
  7. ↑ "23 nya ämnen kan klassas som narkotika eller hälsofarlig vara". Folkhälsomyndigheten. https://www.folkhalsomyndigheten.se/nyheter-och-press/nyhetsarkiv/2015/juni/23-nya-amnen-kan-klassas-som-narkotika-eller-halsofarlig-vara. 



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