Triethylene glycol dimethyl ether

Triethylene glycol dimethyl ether
Names
	Preferred IUPAC name 2,5,8,11-Tetraoxadodecane
	Other names Triglyme; 1,2-Bis(2-methoxyethoxy)ethane
Identifiers
CAS Number	112-49-2 ;
3D model (JSmol)	Interactive image;
Abbreviations	TEGDME
ChEBI	CHEBI:31967;
ChemSpider	13835222;
PubChem CID	8189;
UNII	32YXG88KK0 ;
	InChI InChI=1S/C8H18O4/c1-9-3-5-11-7-8-12-6-4-10-2/h3-8H2,1-2H3 Key: YFNKIDBQEZZDLK-UHFFFAOYSA-N;
	SMILES COCCOCCOCCOC;
Properties
Chemical formula	C8H18O4
Molar mass	178.228 g·mol−1
Appearance	Colorless liquid
Density	0.986 g/cm3
Melting point	−45 °C (−49 °F; 228 K)
Boiling point	216 °C (421 °F; 489 K)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Triethylene glycol dimethyl ether (also called triglyme) is a glycol ether and solvent. It is used as a reaction medium in organic chemistry,^[1] as well as a component of certain brake fluids, paints, adhesives, and paint strippers.^[2]^[3]^[4]

Triglyme has also been investigated as a green alternative to traditional hypergolic rocket propellants.^[5]

References

↑ Fieser, Louis Frederick; Fieser, Mary (1967). Reagents for Organic Synthesis. Wiley. pp. 239,1110. https://books.google.com/books?id=zNXvAAAAMAAJ&dq=triglyme+solvents+table. Retrieved 2025-10-13.
↑ "Actual and Potential Uses of Fourteen Selected Glymes". Abt Associates. 9 September 2009. https://www.regulations.gov/document/EPA-HQ-OPPT-2009-0767-0014.
↑ "Ethylene Glycol Ethers; Significant New Use Rule". Environmental Protection Agency. 16 December 2014. https://www.federalregister.gov/documents/2014/12/16/2014-29429/ethylene-glycol-ethers-significant-new-use-rule.
↑ Tang, Shaokun; Zhao, Hua (2014). "Glymes as Versatile Solvents for Chemical Reactions and Processes: from the Laboratory to Industry". RSC Advances 4 (22). doi:10.1039/C3RA47191H.
↑ Moser, Abigayle; Ji, Christopher; Potthast, Kevin; Amin, Yash; Dalton, Robert; Damjanov, Andrej; Romanowski, Joshua; Grimsich, Tyler et al. (8 January 2026). "Development of an Optically Accessible Green Hypergolic Rocket Engine with Bi Swirl Injector". AIAA SciTech 2026 Forum. https://doi.org/10.2514/6.2026-1601.

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[Fieser1967-1] Fieser, Louis Frederick; Fieser, Mary (1967). Reagents for Organic Synthesis. Wiley. pp. 239,1110. https://books.google.com/books?id=zNXvAAAAMAAJ&dq=triglyme+solvents+table. Retrieved 2025-10-13.

[Abt2009-2] "Actual and Potential Uses of Fourteen Selected Glymes". Abt Associates. 9 September 2009. https://www.regulations.gov/document/EPA-HQ-OPPT-2009-0767-0014.

[EPA-SNUR2014-3] "Ethylene Glycol Ethers; Significant New Use Rule". Environmental Protection Agency. 16 December 2014. https://www.federalregister.gov/documents/2014/12/16/2014-29429/ethylene-glycol-ethers-significant-new-use-rule.

[TangZhao2014-4] Tang, Shaokun; Zhao, Hua (2014). "Glymes as Versatile Solvents for Chemical Reactions and Processes: from the Laboratory to Industry". RSC Advances 4 (22). doi:10.1039/C3RA47191H.

[5] Moser, Abigayle; Ji, Christopher; Potthast, Kevin; Amin, Yash; Dalton, Robert; Damjanov, Andrej; Romanowski, Joshua; Grimsich, Tyler et al. (8 January 2026). "Development of an Optically Accessible Green Hypergolic Rocket Engine with Bi Swirl Injector". AIAA SciTech 2026 Forum. https://doi.org/10.2514/6.2026-1601.

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Triethylene glycol dimethyl ether

Topic: Chemistry

See also

References