Valine

Valine

Skeletal formula of neutral valine Zwitterionic valine
Ball-and-stick model Space-filling model
Names
IUPAC name Valine
Other names 2-Amino-3-methylbutanoic acid 2-Aminoisovaleric acid Valic acid
Identifiers
CAS Number	L: 72-18-4 Y D/L: 516-06-3 Y D: 640-68-6 Y
3D model (JSmol)	L: Interactive image L Zwitterion: Interactive image
ChEBI	L: CHEBI:16414 Y
ChEMBL	L: ChEMBL43068 Y
ChemSpider	L: 6050 Y D/L: 1148 Y D: 64635 Y
DrugBank	L: DB00161 Y
EC Number	L: 200-773-6
IUPHAR/BPS	L: 4794
KEGG	L: D00039 Y
PubChem CID	L: 6287 D/L: 1182 D: 71563
UNII	L: HG18B9YRS7 Y D/L: 4CA13A832H Y D: Y14I1443UR Y
InChI InChI=1S/C5H11NO2/c1-3(2)4(6)5(7)8/h3-4H,6H2,1-2H3,(H,7,8)/t4-/m0/s1 Y Key: KZSNJWFQEVHDMF-BYPYZUCNSA-N Y D/L: Key: KZSNJWFQEVHDMF-UHFFFAOYSA-N D: Key: KZSNJWFQEVHDMF-SCSAIBSYSA-N
SMILES L: CC(C)[C@@H](C(=O)O)N L Zwitterion: CC(C)[C@@H](C(=O)[O-])[NH3+]
Properties[3]
Chemical formula	C5H11NO2
Molar mass	117.148 g·mol−1
Density	1.316 g/cm3
Melting point	298 °C (568 °F; 571 K) (decomposition)
Solubility in water	soluble, 85 g/L [1]
Acidity (pKa)	2.32 (carboxyl), 9.62 (amino)[2]
Magnetic susceptibility (χ)	-74.3·10−6 cm3/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Valine (symbol Val or V)^[4] is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH₃⁺ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO⁻ form under biological conditions), and a side chain isopropyl group, making it a non-polar aliphatic amino acid. It is essential in humans, meaning the body cannot synthesize it: it must be obtained from the diet. Human dietary sources are foods that contain protein, such as meats, dairy products, soy products, beans and legumes. It is encoded by all codons starting with GU (GUU, GUC, GUA, and GUG).

History and etymology

Valine was first isolated from casein in 1901 by Hermann Emil Fischer.^[5] The name valine comes from valeric acid, which in turn is named after the plant valerian due to the presence of the acid in the roots of the plant.^[6][7]

Nomenclature

According to IUPAC, carbon atoms forming valine are numbered sequentially starting from 1 denoting the carboxyl carbon, whereas 4 and 4' denote the two terminal methyl carbons.^[8]

Metabolism

Source and biosynthesis

Valine, like other branched-chain amino acids, is synthesized by bacteria and plants, but not by animals.^[9] It is therefore an essential amino acid in animals, and needs to be present in the diet. Adult humans require about 24 mg/kg body weight daily.^[10] It is synthesized in plants and bacteria via several steps starting from pyruvic acid. The initial part of the pathway also leads to leucine. The intermediate α-ketoisovalerate undergoes reductive amination with glutamate. Enzymes involved in this biosynthesis include:^[11]

1. Acetolactate synthase (also known as acetohydroxy acid synthase)
2. Acetohydroxy acid isomeroreductase
3. Dihydroxyacid dehydratase
4. Valine aminotransferase

Degradation

Like other branched-chain amino acids, the catabolism of valine starts with the removal of the amino group by transamination, giving alpha-ketoisovalerate, an alpha-keto acid, which is converted to isobutyryl-CoA through oxidative decarboxylation by the branched-chain α-ketoacid dehydrogenase complex.^[12] This is further oxidised and rearranged to succinyl-CoA, which can enter the citric acid cycle.

Synthesis

Racemic valine can be synthesized by bromination of isovaleric acid followed by amination of the α-bromo derivative^[13]

HO₂CCH₂CH(CH₃)₂ + Br₂ → HO₂CCHBrCH(CH₃)₂ + HBr

HO₂CCHBrCH(CH₃)₂ + 2 NH₃ → HO₂CCH(NH₂)CH(CH₃)₂ + NH₄Br

Medical significance

Metabolic diseases

The degradation of valine is impaired in the following metabolic diseases:

• Combined malonic and methylmalonic aciduria (CMAMMA)
• Maple syrup urine disease (MSUD)
• Methylmalonic acidemia
• Propionic acidemia

Insulin resistance

Lower levels of serum valine, like other branched-chain amino acids, are associated with weight loss and decreased insulin resistance: higher levels of valine are observed in the blood of diabetic mice, rats, and humans.^[14] Mice fed a BCAA-deprived diet for one day had improved insulin sensitivity, and feeding of a valine-deprived diet for one week significantly decreases blood glucose levels.^[15] In diet-induced obese and insulin resistant mice, a diet with decreased levels of valine and the other branched-chain amino acids resulted in a rapid reversal of the adiposity and an improvement in glucose-level control.^[16] The valine catabolite 3-hydroxyisobutyrate promotes insulin resistance in mice by stimulating fatty acid uptake into muscle and lipid accumulation.^[17] In mice, a BCAA-restricted diet decreased fasting blood glucose levels and improved body composition.^[18]

Hematopoietic stem cells

Dietary valine is essential for hematopoietic stem cell (HSC) self-renewal, as demonstrated by experiments in mice.^[19] Dietary valine restriction selectively depletes long-term repopulating HSC in mouse bone marrow. Successful stem cell transplantation was achieved in mice without irradiation after 3 weeks on a valine restricted diet. Long-term survival of the transplanted mice was achieved when valine was returned to the diet gradually over a 2-week period to avoid refeeding syndrome.

See also

• Valinol

References

External links

• Valine MS Spectrum
• Isoleucine and valine biosynthesis
• Valine's relationship to prions

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