WAY-208466

WAY-208466
Clinical data
ATC code	none;
Identifiers
	IUPAC name 2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-1-yl}-N,N-dimethylethanamine;
CAS Number	633304-27-5 ; 1207064-61-6 (2 HCl);
PubChem CID	10337743;
ChemSpider	8513202;
UNII	0AXW9ALG9W;
ChEMBL	ChEMBL571858;
Chemical and physical data
Formula	C17H18FN3O2S
Molar mass	347.41 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC=CC(=C3)F;

Short description: Chemical compound

WAY-208466 is a potent and highly selective full agonist of the 5-HT₆ receptor.^[1] It increases GABA levels in the cerebral cortex and tolerance does not appear to occur to this action upon chronic administration.^[1] Animal studies have shown that WAY-208466 produces antidepressant and anxiolytic effects in rodents and it may also be useful in the treatment of obsessive-compulsive disorder.^[1]^[2]

References

↑ ^1.0 ^1.1 ^1.2 "Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466". Neuropsychopharmacology 33 (6): 1323–35. May 2008. doi:10.1038/sj.npp.1301503. PMID 17625499.
↑ "Antidepressant and anxiolytic effects of selective 5-HT(6) receptor agonists in rats". Psychopharmacology 213 (2–3): 499–507. March 2010. doi:10.1007/s00213-010-1798-7. PMID 20217056.

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[pmid17625499-1] 1.0 ^1.1 ^1.2 "Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466". Neuropsychopharmacology 33 (6): 1323–35. May 2008. doi:10.1038/sj.npp.1301503. PMID 17625499.

[pmid20217056-2] "Antidepressant and anxiolytic effects of selective 5-HT(6) receptor agonists in rats". Psychopharmacology 213 (2–3): 499–507. March 2010. doi:10.1007/s00213-010-1798-7. PMID 20217056.

[1]

[2]

WAY-208466

Topic: Chemistry

See also

References

Clinical data

ATC code	none
Identifiers
IUPAC name 2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-1-yl}-N,N-dimethylethanamine
CAS Number	633304-27-5 1207064-61-6 (2 HCl)
PubChem CID	10337743
ChemSpider	8513202
UNII	0AXW9ALG9W
ChEMBL	ChEMBL571858
Chemical and physical data
Formula	C₁₇H₁₈FN₃O₂S
Molar mass	347.41 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CN(C)CCN1C=C(C2=C1N=CC=C2)S(=O)(=O)C3=CC=CC(=C3)F