WYE-687

WYE-687
Identifiers
	IUPAC name methyl N-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate;
CAS Number	1062161-90-3;
PubChem CID	25229450;
ChemSpider	24626255;
ChEMBL	ChEMBL561103;
Chemical and physical data
Formula	C28H32N8O3
Molar mass	528.617 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6;
	InChI InChI=1S/C28H32N8O3/c1-38-28(37)31-22-6-4-21(5-7-22)25-32-26(35-13-15-39-16-14-35)24-18-30-36(27(24)33-25)23-8-11-34(12-9-23)19-20-3-2-10-29-17-20/h2-7,10,17-18,23H,8-9,11-16,19H2,1H3,(H,31,37); Key:VDOCQQKGPJENHJ-UHFFFAOYSA-N;

Short description: Chemical compound

WYE-687 is a drug which acts as an inhibitor of both subtypes of the mechanistic target of rapamycin (mTOR), mTORC1 and mTORC2. It is being researched for potential applications in the treatment of various forms of cancer.^[1]^[2]^[3]

References

↑ "Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin". Cancer Research 69 (15): 6232–40. August 2009. doi:10.1158/0008-5472.CAN-09-0299. PMID 19584280.
↑ "Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent". Biochemical and Biophysical Research Communications 470 (2): 324–330. February 2016. doi:10.1016/j.bbrc.2016.01.054. PMID 26792718.
↑ "Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo". PLOS ONE 12 (3): e0172555. 2017. doi:10.1371/journal.pone.0172555. PMID 28257457. Bibcode: 2017PLoSO..1272555P.

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[1] "Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin". Cancer Research 69 (15): 6232–40. August 2009. doi:10.1158/0008-5472.CAN-09-0299. PMID 19584280.

[2] "Preclinical evaluation of WYE-687, a mTOR kinase inhibitor, as a potential anti-acute myeloid leukemia agent". Biochemical and Biophysical Research Communications 470 (2): 324–330. February 2016. doi:10.1016/j.bbrc.2016.01.054. PMID 26792718.

[3] "Concurrent inhibition of mTORC1 and mTORC2 by WYE-687 inhibits renal cell carcinoma cell growth in vitro and in vivo". PLOS ONE 12 (3): e0172555. 2017. doi:10.1371/journal.pone.0172555. PMID 28257457. Bibcode: 2017PLoSO..1272555P.

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Identifiers

IUPAC name methyl N-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate
CAS Number	1062161-90-3
PubChem CID	25229450
ChemSpider	24626255
ChEMBL	ChEMBL561103
Chemical and physical data
Formula	C₂₈H₃₂N₈O₃
Molar mass	528.617 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6
InChI InChI=1S/C28H32N8O3/c1-38-28(37)31-22-6-4-21(5-7-22)25-32-26(35-13-15-39-16-14-35)24-18-30-36(27(24)33-25)23-8-11-34(12-9-23)19-20-3-2-10-29-17-20/h2-7,10,17-18,23H,8-9,11-16,19H2,1H3,(H,31,37) Key:VDOCQQKGPJENHJ-UHFFFAOYSA-N

WYE-687

Topic: Chemistry

References