Zinc picolinate

Zinc picolinate
Identifiers
CAS Number	17949-65-4;
3D model (JSmol)	Interactive image;
ChemSpider	8080400;
PubChem CID	9904746;
UNII	ALO92O31SE;
	InChI InChI=1S/2C6H5NO2.Zn/c28-6(9)5-3-1-2-4-7-5;/h21-4H,(H,8,9);/q;;+2/p-2 Key: NHVUUBRKFZWXRN-UHFFFAOYSA-L;
	SMILES C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].[Zn+2];
Properties
Chemical formula	C12H12N2O6Zn
Molar mass	345.62 g·mol−1
Hazards
GHS pictograms
GHS Signal word	Warning
GHS hazard statements	H302, H315, H319, H335, H410
GHS precautionary statements	P261, P264, P270, P271, P273, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362, P391, P403+233, P405, P501
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

Zinc picolinate (or ZnPic) is the zinc coordination complex derived from picolinic acid and zinc(II). It has the formula Zn(NC
5H
4CO
2)
2(H
2O)
2. The complex adopts an octahedral molecular geometry, containing two bidentate picolinate ligands (conjugate base of picolinic acid) and two aquo ligands. Additionally, two water of crystallization are present, thus the compound crystallizes with the formula Zn(NC
5H
4CO
2)
2(H
2O)
2 · 2H₂O.^[1] It is a colorless solid.

Related compounds

Other zinc(II) complexes of picolinic acid have been described.^[2] Isostructural with the zinc complex are M(NC
5H
4CO
2)
2(H
2O)
2 · 2H₂O (M = Co and Ni).^[3]

Dietary supplement

Zinc picolinate has been used as a dietary zinc supplement.^[4]^[5]^[6]

References

↑ Lumme, Paavo; Lundgren, Georg; Mark, Wanda; Lundström, Hans; Borch, Gunner; Craig, J. Cymerman (1969). "The Crystal Structure of Zinc Picolinate Tetrahydrate, Zn(C₆H₄O₂N)₂(H₂O)₄". Acta Chemica Scandinavica 23: 3011–3022. doi:10.3891/acta.chem.scand.23-3011.
↑ Vargová, Zuzana; Zeleòák, Vladimı́r; Cı́Saøová, Ivana; Györyová, Katarı́na (2004). "Correlation of Thermal and Spectral Properties of Zinc(II) Complexes of Pyridinecarboxylic Acids with Their Crystal Sructures". Thermochimica Acta 423 (1–2): 149–157. doi:10.1016/j.tca.2004.03.016.
↑ Tella, Adedibu C.; Oladipo, Adetola C.; Adeyemi, Olalere G.; Oluwafemi, Oluwatobi S.; Oguntoye, Stephen O.; Alimi, Lukman O.; Ajayi, Joseph T.; Degni, Sylvestre K. (2017). "Solid State Synthesis, Spectroscopic and X-Ray Studies of Metal Complexes of 2-Picolinic Acid and Vapochromic Behavior of [Co(Pic)₂(H₂O)₂ ]·2H₂O". Solid State Sciences 68: 1–9. doi:10.1016/j.solidstatesciences.2017.03.017.
↑ "Zinc: Health Effects and Research Priorities for the 1990s". Environmental Health Perspectives 102 (Suppl 2): 5–46. June 1994. doi:10.1289/ehp.941025. PMID 7925188.
↑ "Double-Blind, Placebo-Controlled Trial of Zinc Picolinate for Taste Disorders". Acta Oto-Laryngologica. Supplementum 122 (546): 129–33. 2002. doi:10.1080/00016480260046517. PMID 12132610.
↑ "Comparative Absorption of Zinc Picolinate, Zinc Citrate and Zinc Gluconate in Humans". Agents and Actions 21 (1–2): 223–8. June 1987. doi:10.1007/BF01974946. PMID 3630857.

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[1] Lumme, Paavo; Lundgren, Georg; Mark, Wanda; Lundström, Hans; Borch, Gunner; Craig, J. Cymerman (1969). "The Crystal Structure of Zinc Picolinate Tetrahydrate, Zn(C₆H₄O₂N)₂(H₂O)₄". Acta Chemica Scandinavica 23: 3011–3022. doi:10.3891/acta.chem.scand.23-3011.

[2] Vargová, Zuzana; Zeleòák, Vladimı́r; Cı́Saøová, Ivana; Györyová, Katarı́na (2004). "Correlation of Thermal and Spectral Properties of Zinc(II) Complexes of Pyridinecarboxylic Acids with Their Crystal Sructures". Thermochimica Acta 423 (1–2): 149–157. doi:10.1016/j.tca.2004.03.016.

[3] Tella, Adedibu C.; Oladipo, Adetola C.; Adeyemi, Olalere G.; Oluwafemi, Oluwatobi S.; Oguntoye, Stephen O.; Alimi, Lukman O.; Ajayi, Joseph T.; Degni, Sylvestre K. (2017). "Solid State Synthesis, Spectroscopic and X-Ray Studies of Metal Complexes of 2-Picolinic Acid and Vapochromic Behavior of [Co(Pic)₂(H₂O)₂ ]·2H₂O". Solid State Sciences 68: 1–9. doi:10.1016/j.solidstatesciences.2017.03.017.

[4] "Zinc: Health Effects and Research Priorities for the 1990s". Environmental Health Perspectives 102 (Suppl 2): 5–46. June 1994. doi:10.1289/ehp.941025. PMID 7925188.

[5] "Double-Blind, Placebo-Controlled Trial of Zinc Picolinate for Taste Disorders". Acta Oto-Laryngologica. Supplementum 122 (546): 129–33. 2002. doi:10.1080/00016480260046517. PMID 12132610.

[6] "Comparative Absorption of Zinc Picolinate, Zinc Citrate and Zinc Gluconate in Humans". Agents and Actions 21 (1–2): 223–8. June 1987. doi:10.1007/BF01974946. PMID 3630857.

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Identifiers

CAS Number	17949-65-4
3D model (JSmol)	Interactive image
ChemSpider	8080400
PubChem CID	9904746
UNII	ALO92O31SE
InChI InChI=1S/2C6H5NO2.Zn/c28-6(9)5-3-1-2-4-7-5;/h21-4H,(H,8,9);/q;;+2/p-2 Key: NHVUUBRKFZWXRN-UHFFFAOYSA-L
SMILES C1=CC=NC(=C1)C(=O)[O-].C1=CC=NC(=C1)C(=O)[O-].[Zn+2]
Properties
Chemical formula	C₁₂H₁₂N₂O₆Zn
Molar mass	345.62 g·mol⁻¹
Hazards
GHS pictograms
GHS Signal word	Warning
GHS hazard statements	H302, H315, H319, H335, H410
GHS precautionary statements	P261, P264, P270, P271, P273, P280, P301+312, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362, P391, P403+233, P405, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Zinc picolinate

Topic: Chemistry

Related compounds

Dietary supplement

References