Atypical small acinar proliferation

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Atypical small acinar proliferation
Other namesASAP

In urologic pathology, atypical small acinar proliferation, is a collection of small prostatic glands, on prostate biopsy, whose significance is uncertain and cannot be determined to be benign or malignant.

ASAP, generally, is not considered a pre-malignancy, or a carcinoma in situ; it is an expression of diagnostic uncertainty,[1] and analogous to the diagnosis of ASCUS (atypical squamous cells of undetermined significance) on the Pap test.

Association with adenocarcinoma

On a subsequent biopsy, given the diagnosis of ASAP, the chance of finding prostate adenocarcinoma is approximately 40%; this is higher than if there is high-grade prostatic intraepithelial neoplasia (HGPIN).[2]

Management

ASAP is considered an indication for re-biopsy;[3] in one survey of urologists[4] 98% of respondents considered it a sufficient reason to re-biopsy.

See also

  • Sensitivity

References

External links

Classification
External resources




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