Atypical small acinar proliferation

In urologic pathology, atypical small acinar proliferation, is a collection of small prostatic glands, on prostate biopsy, whose significance is uncertain and cannot be determined to be benign or malignant.

ASAP, generally, is not considered a pre-malignancy, or a carcinoma in situ; it is an expression of diagnostic uncertainty,^[1] and analogous to the diagnosis of ASCUS (atypical squamous cells of undetermined significance) on the Pap test.

On a subsequent biopsy, given the diagnosis of ASAP, the chance of finding prostate adenocarcinoma is approximately 40%; this is higher than if there is high-grade prostatic intraepithelial neoplasia (HGPIN).^[2]

ASAP is considered an indication for re-biopsy;^[3] in one survey of urologists^[4] 98% of respondents considered it a sufficient reason to re-biopsy.

• Sensitivity

0.00 (0 votes) Original source: https://en.wikipedia.org/wiki/Atypical small acinar proliferation. Read more