Table of Contents Categories
  Encyclosphere.org ENCYCLOREADER
  supported by EncyclosphereKSF

Cytomegalovirus colitis

Topic: Medicine

 From HandWiki - Reading time: 5 min

Cytomegalovirus colitis
Other namesCMV colitis
Micrograph of CMV colitis. H&E stain.
SpecialtyInfectious diseases

Cytomegalovirus colitis (CMV colitis) is an inflammation of the colon.

Causes

Risk factors

The systemic use of corticosteroids in the context of inflammatory bowel disease can promote CMV infection in the colon.[1] The corticosteroids used as a primary treatment for flare-up events of inflammatory bowel disease reduce the autoimmune activity of the T lymphocytes and monocytes that contribute to the inflammation of the colon and small intestine. By inhibiting the function of these leukocytes, corticosteroids reduce the inflammation caused by IBD, but this immunosuppression enables CMV to infect the colon.[2] Similarly, use of the immunosuppressive drug that is required to decrease risk of rejection in patients who received transplant as Liver transplantation or Kidney transplantation is a risk factor for CMV infection.[3]

Diagnosis

Treatment

The usual treatment is antivirals, specifically ganciclovir or valganciclovir.[1] Severe CMV colitis may lead a colectomy.[4]

See also

References

  1. ↑ 1.0 1.1 "Cytomegalovirus colitis complicating inflammatory bowel disease". American Journal of Gastroenterology 101 (12): 2857–65. December 2006. doi:10.1111/j.1572-0241.2006.00869.x. PMID 17026558. 
  2. ↑ Jentzer, Alexandre; Veyrard, Pauline; Roblin, Xavier; Saint-Sardos, Pierre; Rochereau, Nicolas; Paul, Stéphane; Bourlet, Thomas; Pozzetto, Bruno et al. (2020-07-20). "Cytomegalovirus and Inflammatory Bowel Diseases (IBD) with a Special Focus on the Link with Ulcerative Colitis (UC)" (in en). Microorganisms 8 (7): 1078. doi:10.3390/microorganisms8071078. ISSN 2076-2607. PMID 32698383. 
  3. ↑ Zais IE, Sirotti A, Iesari S, Campioli E, Costantino A, Delbue S, Collini A, Guarneri A, Ambrogi F, Cacciola R, Ferraresso M, Favi E. Human cytomegalovirus-related gastrointestinal disease after kidney transplantation: A systematic review. Clin Transplant. 2023 Dec 8:e15218. doi: 10.1111/ctr.15218. Epub ahead of print. PMID 38063324.
  4. ↑ "Cytomegalovirus in inflammatory bowel disease: pathogen or innocent bystander?". Inflamm. Bowel Dis. 16 (9): 1620–7. September 2010. doi:10.1002/ibd.21275. PMID 20232408. 



Retrieved from "https://handwiki.org/wiki/index.php?title=Medicine:Cytomegalovirus_colitis&oldid=4171820"
Licensed under CC BY-SA 3.0 | Source: https://handwiki.org/wiki/Medicine:Cytomegalovirus_colitis
2 views |
↧ Download this article as ZWI file
Encyclosphere.org EncycloReader is supported by the EncyclosphereKSF