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Epidemiology of schizophrenia

Topic: Medicine

 From HandWiki - Reading time: 5 min
DALY for schizophrenia per 100,000 inhabitants in 2004.
  no data
  ≤ 185
  185–197
  197–207
  207–218
  218–229
  229–240
  240–251
  251–262
  262–273
  273–284
  284–295
  ≥ 295

Schizophrenia affects around 0.3–0.7% of people at some point in their life,[1] or 21 million people worldwide as of 2011 (about one of every 285).[2] By using precise methods in its diagnosis and a large, representative population, schizophrenia seems to occur with relative consistency over time during the last half-century.[3]

While it is claimed that schizophrenia occurs at similar rates worldwide, its prevalence and incidence varies across the world,[4] within countries,[5] and at the local and neighborhood level.[6] It causes approximately 1% of worldwide disability-adjusted life years (DALYs).[7] The rate of schizophrenia varies up to threefold depending on how it is defined.[1]

By age and gender

Schizophrenia is diagnosed 1.4 times more frequently in males than females, and typically appears earlier in men[7]—the peak ages of onset are 20–28 years for males and 26–32 years for females.[8] Onset in childhood is much rarer,[9] as is onset in middle- or old age.[10]

Generally, the mean age of first hospital admission for treatment of schizophrenia is between 25 and 35. Studies have suggested that lower income individuals tend to have their disorder diagnosed later after the onset of symptoms, relative to those of better economic standings. As a result, the lower social classes are more likely to be living with their illness untreated.[3]

It is generally accepted that women tend to present with schizophrenia anywhere between 4–10 years after their male counterparts.[11] However, using broad criteria for diagnosing schizophrenia shows that males have a bimodal age of onset, with peaks at 21.4 years and 39.2 years old, while females have a trimodal age of onset with peaks at 22.4, 36.6, and 61.5 years old.[12]

This additional post-menopausal peak of late-onset schizophrenia in women calls into question the etiology of the disease and raises a debate about "subtypes" of schizophrenia, with men and women being susceptible to different types (see Causes of Schizophrenia). This is further supported by the variability in presentation of the disease between the genders.[13]

Other theories that may explain this difference include protective or predisposing factors in men or women that may render them more (or less) susceptible to the disease at different points in life. For example, estrogen may be a protective factor for women, as estradiol has been found to be effective in treating schizophrenia when added to antipsychotic therapy.[13]

By country

In 2000, the World Health Organization found the prevalence and incidence of schizophrenia to be roughly similar around the world, with age-standardized prevalence per 100,000 ranging from 343 in Africa to 544 in Japan and Oceania for men and from 378 in Africa to 527 in Southeastern Europe for women.[14]

However, the impact of schizophrenia tends to be highest in Oceania, the Middle East, and East Asia, while the nations of Australia , Japan , the United States , and most of Europe typically have low impact. Despite relative geographical proximity, the DALY rate of schizophrenia in Indonesia nearly doubles that of Australia (the nations with the highest and lowest respective DALY rates). Discrepancies between DALY rates and prevalence may arise from differences in availability of medical treatment: years lived with mental disorders carry significantly higher DALY values when unmedicated than when medicated.[14]

The following tables record the age-standardised disability-adjusted life years rates per 100,000 inhabitants (recorded in 2004).[15]

United States

In 2010, there were approximately 397,200 hospitalizations for schizophrenia in the United States. About 88,600 (22.3%) were readmitted within 30 days.[16]

See also

  • Prevalence of mental disorders
  • Sex differences in schizophrenia

References

  1. ↑ 1.0 1.1 van Os J, Kapur S. Schizophrenia. Lancet. 2009;374(9690):635–45. doi:10.1016/S0140-6736(09)60995-8. PMID 19700006.
  2. ↑ "Schizophrenia". World Health Organization. 2011. http://www.who.int/mental_health/management/schizophrenia/en/. Retrieved February 27, 2011. 
  3. ↑ 3.0 3.1 Häfner H, an der Heiden W. Epidemiology of Schizophrenia. The Canadian Journal of Psychiatry. 1997;42:139–151. doi:10.1177/070674379704200204.
  4. ↑ Jablensky A, Sartorius N, Ernberg G, et al.. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten-country study. Psychological Medicine Monograph Supplement. 1992;20:1–97. doi:10.1017/S0264180100000904. PMID 1565705.
  5. ↑ Kirkbride JB, Fearon P, Morgan C, et al.. Heterogeneity in incidence rates of schizophrenia and other psychotic syndromes: findings from the 3-center AeSOP study. Archives of General Psychiatry. 2006;63(3):250–8. doi:10.1001/archpsyc.63.3.250. PMID 16520429.
  6. ↑ Kirkbride JB, Fearon P, Morgan C, et al.. Neighbourhood variation in the incidence of psychotic disorders in Southeast London. Social Psychiatry and Psychiatric Epidemiology. 2007;42(6):438–45. doi:10.1007/s00127-007-0193-0. PMID 17473901.
  7. ↑ 7.0 7.1 Picchioni MM, Murray RM. Schizophrenia. BMJ. 2007;335(7610):91–5. doi:10.1136/bmj.39227.616447.BE. PMID 17626963.
  8. ↑ Castle D, Wessely S, Der G, Murray RM. The incidence of operationally defined schizophrenia in Camberwell, 1965–84. The British Journal of Psychiatry. 1991;159:790–4. doi:10.1192/bjp.159.6.790. PMID 1790446.
  9. ↑ Kumra S, Shaw M, Merka P, Nakayama E, Augustin R. Childhood-onset schizophrenia: research update. Canadian Journal of Psychiatry. 2001;46(10):923–30. doi:10.1177/070674370104601004. PMID 11816313.
  10. ↑ Hassett Anne et al., ed (2005). Psychosis in the Elderly. London: Taylor and Francis. p. 6. ISBN 1-84184-394-6. https://books.google.com/?id=eLaMOJ9oj28C&printsec=frontcover&dq=Psychosis+in+the+Elderly. 
  11. ↑ Hafner H, Maurer K, Loffler W, et al.. The epidemiology of early schizophrenia: Influence of age and gender on onset and early course. The British Journal of Psychiatry. 1994;164(23):29–38. PMID 8037899.
  12. ↑ Castle D, Sham P, Murray R.. Differences in distribution of ages of onset in males and females with schizophrenia. Schizophrenia Research. 1998;33(3):179–183. doi:10.1016/s0920-9964(98)00070-x.
  13. ↑ 13.0 13.1 Kulkarni J, Riedel A, de Castella AR, et al.. Estrogen – A potential treatment for schizophrenia. Schizophrenia Research. 2001;48(1):137–144. doi:10.1016/s0920-9964(00)00088-8. PMID 11278160.
  14. ↑ 14.0 14.1 Ayuso-Mateos, Jose Luis. "Global burden of schizophrenia in the year 2000". World Health Organization. http://www.who.int/healthinfo/statistics/bod_schizophrenia.pdf. Retrieved February 27, 2013. 
  15. ↑ "Age-standardized DALYs per 100,000 by cause, and Member State, 2004". Global burden of disease: 2004 update. World Health Organization (WHO). 2004. http://www.who.int/entity/healthinfo/global_burden_disease/gbddeathdalycountryestimates2004.xls. Retrieved 2011-04-01. 
  16. ↑ Elixhauser A, Steiner C. Readmissions to U.S. Hospitals by Diagnosis, 2010. HCUP Statistical Brief #153. Agency for Healthcare Research and Quality. April 2013.

Further reading




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