List of vaccine excipients
Topic: Medicine
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This is a list of excipients per vaccine, as published by the United States Centers for Disease Control. Vaccine ingredients and production in other nations are substantially the same. Also listed are substances used in the manufacturing process.[1]
| Vaccine | Excipients |
|---|---|
| Adenovirus vaccine | This list refers to the type 4 and type 7 adenovirus vaccine tablets licensed in the US: Acetone, alcohol, anhydrous lactose, castor oil, cellulose acetate phthalate, dextrose, D-fructose, D-mannose, FD&C Yellow #6 aluminum lake dye, fetal bovine serum, human serum albumin, magnesium stearate, micro crystalline cellulose, plasdone C, Polacrilin potassium, potassium phosphate, sodium bicarbonate, sucrose |
| Anthrax vaccine (BioThrax) | Aluminum hydroxide, amino acids, benzethonium chloride, formaldehyde, inorganic salts and sugars, vitamins |
| BCG (Bacillus Calmette-Guérin) (Tice BCG) | Asparagine, citric acid, lactose, glycerin, iron ammonium citrate, magnesium sulfate, potassium phosphate |
| COVID-19 vaccines, mRNA-based (Pfizer-BioNTech COVID-19 Vaccine) (Moderna COVID-19 Vaccine) | Lipids, salts, sucrose, plus in the Moderna COVID-19 Vaccine: tromethamine, acids and acid stabilizers[2][3] |
| DTaP (Daptacel) | Aluminum phosphate, formaldehyde, Glutaraldehyde, 2-phenoxyethanol |
| DTaP (Infanrix) | Aluminum hydroxide, bovine extract, formaldehyde, glutaraldhyde, polysorbate 80 |
| DTaP (Tripedia) | Aluminum potassium sulfate, ammonium sulfate, bovine extract, formaldehyde, gelatin, peptone, polysorbate 80, sodium phosphate, thimerosal[4] |
| DTaP-Hib (TriHIBit) | Aluminum potassium sulfate, ammonium sulfate, bovine extract, formaldehyde or formalin, gelatin, polysorbate 80, sucrose, thimerosal[4] |
| DTaP-IPV (Kinrix) | Aluminum hydroxide, calf serum, formaldehyde, glutaraldehyde, lactalbumin hydrolysate, neomycin sulfate, polymyxin B, polysorbate 80 |
| DTaP-HepB-IPV (Pediarix) | Aluminum hydroxide, aluminum phosphate, calf serum, lactalbumin hydrolysate, formaldehyde, glutaraldhyde, neomycin sulfate, polymyxin B, polysorbate 80, yeast protein |
| DTaP-IPV-Hib (Pentacel) | Aluminum phosphate, bovine serum albumin, formaldehyde, glutaraldehyde, MRC-5 cellular protein, neomycin, polymyxin B sulfate, polysorbate 80, 2-phenoxyethanol |
| DT vaccine (diphtheria vaccine plus tetanus vaccine) (Sanofi) | Aluminum potassium sulfate, bovine extract, formaldehyde, thimerosal |
| DT vaccine (Massachusetts) | Aluminum hydroxide, formaldehyde or formalin |
| Hib vaccine (ActHIB) | Ammonium sulfate, formaldehyde, sucrose[5] |
| Hib vaccine (PedvaxHib) | Aluminum hydroxyphosphate sulfate[6] |
| Hib vaccine (Hiberix) | Formaldehyde, lactose[7] |
| Hib-HepB (Comvax) | Amorphous aluminum hydroxyphosphate sulfate, amino acids, dextrose, formaldehyde, hemin chloride, mineral salts, nicotinamide adenine dinucleotide, potassium aluminum sulfate, sodium borate, soy peptone, yeast protein |
| Hepatitis A vaccine (Havrix) | Aluminum hydroxide, amino acid supplement, formalin, MRC-5 cellular protein, neomycin sulfate, phosphate buffers, polysorbate 20 |
| Hepatitis A vaccine (Vaqta) | Amorphous aluminum hydroxyphosphate sulfate, bovine albumin or serum, formaldehyde, MRC-5 cellular protein, sodium borate |
| Hepatitis B vaccine (Engerix-B) | Aluminum hydroxide, phosphate buffers, yeast protein |
| Hepatitis B vaccine (Recombivax HB) | Amorphous aluminum hydroxyphosphate sulfate, amino acids, dextrose, formaldehyde, mineral salts, potassium aluminum sulfate, soy peptone, yeast protein |
| HepA-HepB vaccine (Twinrix) | Aluminum hydroxide, aluminum phosphate, amino acids, formalin, MRC-5 cells, neomycin sulfate, phosphate buffers, polysorbate 20, yeast protein |
| Human papillomavirus (HPV) (Cervarix) | Aluminum hydroxide, amino acids, lipids, mineral salts, sodium dihydrogen phosphate dehydrate, type 16 viral protein L1, type 18 viral protein L1, vitamins |
| Human papillomavirus (HPV) (Gardasil) | Amino acids, amorphous aluminum hydroxyphosphate sulfate, carbohydrates, L-histidine, mineral salts, polysorbate 80, sodium borate, vitamins, yeast protein |
| Influenza vaccine (Afluria) | Beta-propiolactone, calcium chloride, dibasic sodium phosphate, egg protein, monobasic potassium phosphate, monobasic sodium phosphate, neomycin sulfate, polymyxin B, potassium chloride, sodium taurodeoxychoalate, thimerosal (multi-dose vials only) |
| Influenza vaccine (Agriflu) | Egg proteins, formaldehyde, polysorbate 80, cetyltrimethylammonium bromide, neomycin sulfate, kanamycin |
| Influenza vaccine (Fluad) | Squalene, polysorbate 80, sorbitan trioleate, sodium citrate dehydrate, citric acid monohydrate, neomycin, kanamycin, barium, egg proteins, CTAB(cetyltrimethylammonium bromide), formaldehyde |
| Influenza vaccine (Fluarix) | Formaldehyde, octoxynol-10 (Triton X-100), α-tocopheryl hydrogen succinate, polysorbate 80 (Tween 80), hydrocortisone, gentamicin sulfate, ovalbumin, sodium deoxycholate, sucrose, phosphate buffer |
| Influenza vaccine (Flublok) | Monobasic sodium phosphate, dibasic sodium phosphate, polysorbate 20, baculovirus and host cell proteins, baculovirus and cellular DNA, Triton X-100, lipids, vitamins, amino acids, mineral salts |
| Influenza vaccine (Flucelvax) | Madin Darby Canine Kidney (MDCK) cell protein, MDCK cell DNA, polysorbate 80, cetyltrimethlyammonium bromide, β-propiolactone, phosphate buffer |
| Influenza vaccine (Flulaval) | Formaldehyde, á-tocopheryl hydrogen succinate, polysorbate 80, sodium deoxycholate, thimerosal, ovalbumin |
| Influenza vaccine (Fluvirin) | Beta-propiolactone, egg protein, neomycin, nonylphenol ethoxylate, polymyxin, thimerosal (multi-dose containers), thimerosal[4] (single-dose syringes) |
| Influenza vaccine (Fluzone) | Egg protein, formaldehyde, gelatin (standard formulation only), octylphenol ethoxylate (Triton X-100), sodium phosphate, thimerosal (multi-dose containers only) |
| Influenza vaccine (FluMist) | Arginine, dibasic potassium phosphate, egg protein, ethylenediaminetetraacetic acid, gentamicin sulfate, hydrolyzed porcine gelatin, monobasic potassium phosphate, monosodium glutamate, sucrose |
| Japanese encephalitis vaccine (JE-Vax) | Formaldehyde or formalin, gelatin, mouse serum protein, polysorbate 80, thimerosal |
| Japanese encephalitis vaccine (Ixiaro) | Aluminum hydroxide, bovine serum albumin, formaldehyde, protamine sulfate, sodium metabisulphite |
| Meningococcal vaccine (Menactra) | Formaldehyde (Each 0.5 mL dose may contain residual amounts of formaldehyde of less than 2.66 µg (0.000532%), by calculation), phosphate buffers[8] |
| Meningococcal vaccine (Menomune) | Lactose, thimerosal (multi-dose vial only) |
| Meningococcal vaccine (Menveo) | Amino acids, formaldehyde, yeast extract |
| MMR vaccine (MMR-II) | Amino acids, fetal bovine serum, glutamate, hydrolyzed gelatin, neomycin, recombinant human serum albumin, sodium phosphate, sorbitol, sucrose, vitamins |
| MMRV vaccine (ProQuad) | Bovine calf serum, dibasic potassium phosphate, dibasic sodium phosphate, human albumin, human serum albumin, hydrolyzed gelatin, monobasic potassium phosphate, monosodium L-glutamate, MRC-5 cellular protein, neomycin, sodium bicarbonate, sorbitol, sucrose, potassium chloride |
| Pneumococcal vaccine (Pneumovax) | Phenol |
| Pneumococcal vaccine (Prevnar) | Aluminum phosphate, ammonium sulfate, casamino acid, polysorbate 80, succinate buffer, yeast |
| Polio vaccine (IPV – Ipol) | Calf serum protein, formaldehyde, neomycin, 2-phenoxyethanol, polymyxin B, streptomycin |
| Polio vaccine (IPV – Poliovax) | sodium chloride |
| Rabies vaccine (Imovax) | Albumin, MRC-5 cells, neomycin sulfate, phenol |
| Rabies vaccine (RabAvert, Greedo) | Amphotericin B, beta-propiolactone, chicken protein, chlortetracycline, human serum albumin, neomycin, ovalbumin, polygeline (processed bovine 14 gelatin), potassium glutamate |
| Rotavirus vaccine (RotaTeq) | fetal bovine serum, sodium citrate, sodium phosphate monobasic monohydrate, sodium hydroxide, sucrose, polysorbate 80 |
| Rotavirus vaccine (Rotarix) | Amino acids, calcium carbonate, dextran, sorbitol, sucrose, vitamins, xanthan |
| Td vaccine (Decavac) | Aluminum potassium sulfate, bovine muscle tissue, formaldehyde, peptone, thimerosal[4] |
| Td vaccine (Massachusetts) | Aluminum phosphate, ammonium phosphate, bovine extracts, formaldehyde, thimerosal (some multi-dose vials) |
| Tdap vaccine (Adacel) | Aluminum phosphate, ammonium sulfate, formaldehyde, glutaraldehyde, 2-phenoxyethanol |
| Tdap vaccine (Boostrix) | Aluminum hydroxide, bovine extract, formaldehyde, glutaraldehyde, polysorbate 80 |
| Typhoid vaccine (inactivated – Typhim VI) | Disodium phosphate, monosodium phosphate, phenol, polydimethylsiloxane, hexadecyltrimethylammonium bromide |
| Typhoid vaccine (oral – Ty21a/Vivotif) | Amino acids, ascorbic acid, casein, dextrose, galactose, lactose, sucrose, yeast extract |
| Vaccinia (ACAM2000) | Glycerin, human serum albumin, mannitol, neomycin, phenol, polymyxin B |
| Varicella vaccine (Varivax) | Dibasic sodium phosphate, ethylenediamine tetra acetic acid[ sodium (EDTA), fetal bovine serum, gelatin, glutamate, monobasic potassium phosphate, monobasic sodium phosphate, monosodium L-glutamate, MRC-5 DNA and cellular protein, neomycin, phosphate, potassium chloride, sucrose |
| Yellow fever vaccine (YF-Vax) | Egg protein, gelatin, sorbitol |
| Zoster vaccine (Zostavax) | Bovine calf serum, dibasic sodium phosphate, hydrolyzed porcine gelatin, monosodium L-glutamate, MRC-5 DNA and cellular protein, monobasic potassium phosphate, neomycin, potassium chloride, sucrose |
See also
- Excipient
- Vaccine types
- Vaccination schedule
- Adjuvant
- Preservative
- Cell culture
- Growth medium
References
The initial list is based on information from the Centers for Disease Control and Prevention (CDC) and the Food and Drug Administration (FDA) and thus limited to US-approved vaccines.
- ↑ "Vaccine Excipient & Media Summary". https://www.cdc.gov/vaccines/pubs/pinkbook/downloads/appendices/B/excipient-table-2.pdf.
- ↑ Juan C. Ravell (January 11, 2021). "A Simple Breakdown of the Ingredients in the COVID Vaccines". Hackensack Meridian Health. https://www.hackensackmeridianhealth.org/HealthU/2021/01/11/a-simple-breakdown-of-the-ingredients-in-the-covid-vaccines/. Retrieved February 3, 2021.
- ↑ Moderna Covid-19 Vaccine Factsheet
- ↑ 4.0 4.1 4.2 4.3 Note: Thimerosal content less than 0.3 µg.
- ↑ "ActHIB". 24 May 2019. https://www.fda.gov/vaccines-blood-biologics/vaccines/acthib.
- ↑ "Haemophilus B Conjugate Vaccine". 22 July 2017. https://www.fda.gov/vaccines-blood-biologics/vaccines/haemophilus-b-conjugate-vaccine-meningococcal-protein-conjugate.
- ↑ "Hiberix". 30 April 2018. https://www.fda.gov/vaccines-blood-biologics/vaccines/hiberix.
- ↑ Menactra package insert. Sanofi Pasteur. 26 August 2014 v0.12.
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