Outline of life extension

Short description: Overview of and topical guide to life extension

The following outline is provided as an overview of and topical guide to life extension:

Life extension – study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan. Also known as anti-aging medicine, experimental gerontology, and biomedical gerontology.

Goals

Longevity

Strategies

Research and development

Timeline of senescence research

Available strategies

Calorie restriction or protein restriction or intermittent fasting
Exercise
Geroprotector
Senolytics

Potential future strategies

Cryonics
Genetic therapies
- Cloning and body part replacement
- Cell replacement therapies (CRT)
Strategies for engineered negligible senescence (SENS)
Digital immortality through mind uploading
Suspended animation
Immunisation

Aging

Hallmarks of aging

Altered intercellular communication
Cellular senescence
Deregulated nutrient sensing
Epigenetic alterations
Genomic instability
Loss of proteostasis
Mitochondrial dysfunction
Stem cell exhaustion
Telomere attrition

Causes of aging

Cross-links
- Crosslinking of DNA
Free radicals – atom, molecule, or ion that has unpaired valence electrons. With some exceptions, these unpaired electrons make free radicals highly chemically reactive towards other substances, or even towards themselves: their molecules will often spontaneously dimerize or polymerize if they come in contact with each other. They are countered to some extent by antioxidants.
Glycation
- Advanced glycation end-product
Lipofuscin
Viral infections (acute or chronic)

Theories of aging

Antagonistic pleiotropy theory of aging
Caloric restriction theory
Cross-linkage theory of aging
Death hormone theory
Disposable soma theory of aging
DNA damage theory of aging
Epigenetic clock theory of aging
Error catastrophe theory of aging
Errors and Repairs Theory
Free-radical theory of aging
Gene mutation theory
Genetic control theory
Glycation theory of aging
Hayflick limit theory
Inflammation theory of aging
Immunological theory of aging
Log-normal theory of mortality
Membrane theory of aging
Mitochondrial Free Radical Theory of Aging
Mitochondrial Theory of Aging
Mutation accumulation theory of aging
Neuroendocrine theory of aging
Order to disorder theory of aging
Rate of living theory
Redundant DNA theory
Reliability theory of aging and longevity
Reproductive-cell cycle theory
Somatic mutation theory of aging
Telomeric theory of aging
Theory of programmed death
Thermodynamic theory of aging
Thymic-stimulating theory
Waste accumulation theory

Organizations

Alcor Life Extension Foundation
Altos Labs
Alliance for Aging Research
American Academy of Anti-Aging Medicine
American Aging Association
BioViva
Buck Institute for Research on Aging
Calico
Cryonics Institute
International Longevity Alliance
LEV Foundation^[1]
Life Extension Advocacy Foundation
Life Extension Foundation
Methuselah Foundation – non-profit organization dedicated to extending the healthy human lifespan by advancing tissue engineering and regenerative medicine therapies. It was co-founded in 2003 by Aubrey de Grey and David Gobel, and is based in Springfield, Virginia, United States.
SENS Research Foundation – 501(c)(3) non-profit organization co-founded by Michael Kope, Aubrey de Grey, Jeff Hall, Sarah Marr and Kevin Perrott, which is based in Mountain View, California, United States. Its activities include research programs and public relations work for the application of regenerative medicine to aging.

Notable people

Aubrey de Grey
Leonard Hayflick
Zoltan Istvan
Saul Kent
Cynthia Kenyon
Durk Pearson
Sandy Shaw
David Andrew Sinclair
Roy Walford
Michael D. West

References

↑ Garth, Eleanor (2022-10-28). "Aubrey de Grey on longevity at scale" (in en-GB). Longevity.Technology - Latest News, Opinions, Analysis and Research. https://longevity.technology/news/aubrey-de-grey-on-longevity-at-scale.

External links

https://www.sens.org/

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[1] Garth, Eleanor (2022-10-28). "Aubrey de Grey on longevity at scale" (in en-GB). Longevity.Technology - Latest News, Opinions, Analysis and Research. https://longevity.technology/news/aubrey-de-grey-on-longevity-at-scale.

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