Interleukin
From Citizendium - Reading time: 1 min
Interleukins are cytokines that are made by one leukocyte, acting on other leukocytes).
| Name(s) | Source | Target | Function |
|---|---|---|---|
| Il-1a, IL-1b | monocytes, macrophages, B-lymphocytes, DC | TH cells, B cells, NK cells, general inflammation-susceptible | TH cell co-stimulation, B-lymphocyte maturation and proliferation, NK cell activation, general inflammation |
| IL-2 | Th1 cells | activated T- and B-lymphocytes, natural killer cells | growth, proliferation, activation |
| IL-3 | TH cells, NK cells | stem cells, mast cells | stem cell growth and differentiation, mast cells growth and histamine release |
| IL-4 | TH2 cells | activated B cells, macrophages, T cells | IgG1 and IgE synthesis ,macrophage MHC Class II, T cell growth, B cell growth |
| IL-5 | TH2 cells | activated B lymphocytes | proliferation and differentiation, IgA synthesis |
| IL-6 | monocytes, macrophages, TH2 lymphocytes, stromal cells | activated B cells, plasma cells, stem cells, | differentiate B lymphocytes into plasma cells, promotes immunoglobulin synthesis by B lymphocytes, plasma cell antibody secretion, stem cell differentiation, general acute phase response, increases hepcidin secretion |
| IL-7 | marrow and thymus stroma | stem cells | differentiation |
| IL-8 | macrophages and endothelial cells | neutrophils | chemotaxic attraction of neutrophils |
| IL-10 | Th2 cells | macrophages, B-cells | downregulate cytokine production by macrophages, activate B-lymphocytes |
| IL-12 | macrophages, B cells | activated Tc cells, natural killer cells | In combination with IL-2, differentiate Tc cells into CTL; activate NK |
| IL-13 | TH2 cells | Similar to IL-4 |
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Original source: https://citizendium.org/wiki/Interleukin
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Original source: https://citizendium.org/wiki/Interleukin
Status: article is cached
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