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    Makoto Furutani-Seiki

    Topic: Biography

     From Handwiki - Reading time: 5 min
    Makoto Furutani-Seiki
    NationalityJapanese
    Other namesFuruya-Makoto Kiyoki
    Alma materYamaguchi University, University of Tokyo
    Known forMolecular Biology

    Cell Biology Genetics Genomics Cancer Biology Mutation Gene Expression

    Cloning
    Scientific career
    FieldsImmunology

    Developmental Genetics Regenerative Medicine

    Cancer
    InstitutionsYamaguchi University

    University of Tokyo Max Planck Institute, Germany University of Freiburg, Germany Kumamoto University

    University of Bath, UK
    Doctoral advisorTomio Tada[1]
    Websitehttps://researchmap.jp/7000021820?lang=en

    Makoto Furutani-Seiki is Director of UK Research Centre for Regenerative Medicine and Biochemistry Research Division, University of Bath, UK.[2]

    Education

    Furutani-Seiki was educated at the Yamaguchi University[3] School of Medicine, Japan where he was awarded Doctor of Medicine (M.D) in 1985.[4][5][6] He completed his postgraduate study at the Department of Immunology, Graduate School of Medicine, University of Tokyo, Japan where he was awarded a Ph.D in Immunology supervised by the late Tomio Tada[7][8] in 1989.[9]

    Career and research

    Furutani-Seiki started his career in 1992, as a postdoc in Janni Nusslein-Volhard's lab at Max-Planck-Institute in Tübingen, he conducted a genome-wide mutagenesis[10] screen using medaka fish as a group leader of the Kondoh Differentiation Signalling ERATO project.[11][12][9]

    In 2007, he moved to University of Bath, UK, Centre for Regenerative Medicine [13] as a Medical Research Council Senior Research Fellow and continues his research at Yamaguchi University School of Medicine, Japan.[14][9][15]

    Furutani-Seiki research study investigates the molecular mechanisms of mechono-homeostasis in which extracellular mechanical cues are integrated with cell differentiation and proliferation to maintain tissue, organ and body form.[16]

    As part of his contribution to the field of Science, Furutani-Seiki discovered a single gene whose product is essential for the body and organs to keep their 3D shape and withstand external forces such as gravity.[17][18] The gene was discovered through the analysis of a medaka fish mutant with a unique flattened phenotype which was identified by the combination of the mutagenesis screen in zebrafish with another screen in medaka fish.[19][10][20][21][22][23] His work further investigates the single cell lineage and regionalisation of cell populations during medaka neurulation.[17][24]

    Furutani-Seiki led an international team of researchers from the University of Bath, UK Centre for Regenerative Medicine that identified a gene that helps the body resist gravity and demonstrated what happens when the system goes wrong.[25]

    His research contribution covers gravity response, mechanohomeostais, organoid, immunology,[26] cancer,[27] 3D organogenesis,[28] regeneration[29] and developmental genetics;[30] amongst others.[5][31]

    Awards and honours

    Furutani-Seiki is an alumnus of Kavli Frontiers of Science[32] and a member of the editorial board of Regenerative Medicine Research.[33] He's also a Senior Research Fellow UK of the Medical Research Council (MRC).[9] He's also a professional member of the American Association of Cancer Research[34] and the Molecular Biology Society of Japan.[34]

    References

    1. ↑ Taniguchi, Masaru (July 1, 2010). "Obituary for Professor Tomio Tada". International Immunology 22 (7): 541–542. doi:10.1093/intimm/dxq057. 
    2. ↑ "Frühere Forschungsgruppen Entwicklungsbiologie — Institut für Biologie I (Zoologie)". https://www.bio1.uni-freiburg.de/ebio/ebiogroup. 
    3. ↑ "Makoto Furutani-Seiki | Yamaguchi University | Research contributor in Zebrafish, Hippo signaling pathway" (in en). https://typeset.io/authors/makoto-furutani-seiki-2r9i0057wi. 
    4. ↑ "Seiki Makoto - My portal - researchmap". https://researchmap-jp.translate.goog/7000021820?lang=en&_x_tr_sl=ja&_x_tr_tl=en&_x_tr_hl=en&_x_tr_pto=sc. 
    5. ↑ 5.0 5.1 "Makoto Furutani-Seiki". https://0-scholar-google-com.brum.beds.ac.uk/citations?user=lhYUWTEAAAAJ&hl=en. 
    6. ↑ "NBRP Medaka" (in en). https://shigen.nig.ac.jp/medaka/strain/mta.jsp;jsessionid=627879B3F89F3AB3360A3F36E644B29E. 
    7. ↑ Taniguchi, Masaru (2010-07-01). "Obituary for Professor Tomio Tada". International Immunology 22 (7): 541–542. doi:10.1093/intimm/dxq057. ISSN 0953-8178. 
    8. ↑ "Mechanical Force Mediated 3D Organogenesis Withstanding Gravity Controlled by YAP - EPFL". https://memento.epfl.ch/event/mechanical-force-mediated-3d-organogenesis-withsta/. 
    9. ↑ 9.0 9.1 9.2 9.3 "CDB Symposium 2016". http://www.cdb.riken.jp/sympo2016/speakers/05j.html. 
    10. ↑ 10.0 10.1 Taniguchi, Yoshihito; Takeda, Shunichi; Furutani-Seiki, Makoto; Kamei, Yasuhiro; Todo, Takeshi; Sasado, Takao; Deguchi, Tomonori; Kondoh, Hisato et al. (2006-12-08). "Generation of medaka gene knockout models by target-selected mutagenesis". Genome Biology 7 (12): R116. doi:10.1186/gb-2006-7-12-r116. ISSN 1474-760X. PMID 17156454. PMC 1794429. https://doi.org/10.1186/gb-2006-7-12-r116. 
    11. ↑ "Former Groups — Institut für Biologie I (Zoologie)". https://www.bio1.uni-freiburg.de/ebio-en/ebiogroup-en. 
    12. ↑ "ZFIN Person: Furutani-Seiki, Makoto". https://zfin.org/ZDB-PERS-960805-194. 
    13. ↑ "Protocols and Video Articles Authored by Makoto Furutani-Seiki" (in en). https://www.jove.com/author/Makoto_Furutani-Seiki. 
    14. ↑ "Seiki Makoto - My portal - researchmap". https://researchmap.jp/7000021820?lang=en. 
    15. ↑ "Makoto Furutani-Seiki". https://scholar.google.com/citations?user=lhYUWTEAAAAJ&hl=en. 
    16. ↑ Asaoka, Yoichi; Furutani-Seiki, Makoto (2017-12-01). "YAP mediated mechano-homeostasis — conditioning 3D animal body shape" (in en). Current Opinion in Cell Biology. Cell Differentiation and Development 49: 64–70. doi:10.1016/j.ceb.2017.11.013. ISSN 0955-0674. PMID 29253723. https://www.sciencedirect.com/science/article/pii/S0955067417301473. 
    17. ↑ 17.0 17.1 "Single cell lineage and regionalization of cell populations during Medaka neurulation." (in en). https://www.bioseek.eu/us/eng/research/pubmed/Single_cell_lineage_and_regionalization_of_cell_populations_during_Medaka_neurulation_15148299. 
    18. ↑ Porazinski, Sean; Wang, Huijia; Asaoka, Yoichi; Behrndt, Martin; Miyamoto, Tatsuo; Morita, Hitoshi; Hata, Shoji; Sasaki, Takashi et al. (2015-03-16). "YAP is essential for tissue tension to ensure vertebrate 3D body shape". Nature 521 (7551): 217–221. doi:10.1038/nature14215. ISSN 1476-4687. PMID 25778702. PMC 4720436. Bibcode: 2015Natur.521..217P. https://www.scienceopen.com/document?vid=31159260-3b09-47f0-ac49-f1af34e0b249. 
    19. ↑ Hammerschmidt, M.; Pelegri, F.; Mullins, M.C.; Kane, D.A.; Brand, M.; van Eeden, F.J.; Furutani-Seiki, M.; Granato, M. et al. (1996-12-01). "Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio". Development 123 (1): 143–151. doi:10.1242/dev.123.1.143. ISSN 0950-1991. PMID 9007236. https://doi.org/10.1242/dev.123.1.143. 
    20. ↑ Haffter, P.; Odenthal, Jörg; Mullins, M. C.; Lin, Shuo; Farrell, Michael J.; Vogelsang, E.; Haas, F.; Brand, M. et al. (1996-11-01). "Mutations affecting pigmentation and shape of the adult zebrafish" (in en). Development Genes and Evolution 206 (4): 260–276. doi:10.1007/s004270050051. ISSN 1432-041X. PMID 24173565. https://doi.org/10.1007/s004270050051. 
    21. ↑ Furutani-Seiki, Makoto; Wittbrodt, Joachim (2004-07-01). "Medaka and zebrafish, an evolutionary twin study" (in en). Mechanisms of Development. Medaka 121 (7): 629–637. doi:10.1016/j.mod.2004.05.010. ISSN 0925-4773. PMID 15210172. 
    22. ↑ Porazinski, Sean R.; Wang, Huijia; Furutani-Seiki, Makoto (2011). Essential techniques for introducing medaka to a zebrafish laboratory--towards the combined use of medaka and zebrafish for further genetic dissection of the function of the vertebrate genome. Methods in Molecular Biology (Clifton, N.J.). 770. pp. 211–241. doi:10.1007/978-1-61779-210-6_8. ISBN 978-1-61779-209-0. https://pubmed.ncbi.nlm.nih.gov/21805266/. 
    23. ↑ Seo, Jungwon; Asaoka, Yoichi; Nagai, Yoko; Hirayama, Jun; Yamasaki, Tokiwa; Namae, Misako; Ohata, Shinya; Shimizu, Nao et al. (2010-07-01). "Negative regulation of wnt11 expression by Jnk signaling during zebrafish gastrulation". Journal of Cellular Biochemistry 110 (4): 1022–1037. doi:10.1002/jcb.22616. ISSN 1097-4644. PMID 20564202. https://pubmed.ncbi.nlm.nih.gov/20564202/. 
    24. ↑ Hirose, Yukihiro; Varga, Zoltan M.; Kondoh, Hisato; Furutani-Seiki, Makoto (2004-06-01). "Single cell lineage and regionalization of cell populations during Medaka neurulation". Development 131 (11): 2553–2563. doi:10.1242/dev.01140. ISSN 0950-1991. PMID 15148299. https://doi.org/10.1242/dev.01140. 
    25. ↑ "Gravity-resisting gene stops our bodies being squashed flat". https://www.bath.ac.uk/announcements/gravity-resisting-gene-stops-our-bodies-being-squashed-flat/. 
    26. ↑ Shibata, Kensuke; Shimizu, Takashi; Nakahara, Mashio; Ito, Emi; Legoux, Francois; Fujii, Shotaro; Yamada, Yuka; Furutani-Seiki, Makoto et al. (2022-10-01). "The intracellular pathogen Francisella tularensis escapes from adaptive immunity by metabolic adaptation" (in en). Life Science Alliance 5 (10): e202201441. doi:10.26508/lsa.202201441. ISSN 2575-1077. PMID 35667686. PMC 9170078. https://www.life-science-alliance.org/content/5/10/e202201441. 
    27. ↑ Kitagawa, Takao; Kobayashi, Daiki; Baron, Byron; Okita, Hajime; Miyamoto, Tatsuo; Takai, Rie; Paudel, Durga; Ohta, Tohru et al. (2022-05-16). "AT-hook DNA-binding motif-containing protein one knockdown downregulates EWS-FLI1 transcriptional activity in Ewing's sarcoma cells" (in en). PLOS ONE 17 (10): 2022.05.16.492174. doi:10.1101/2022.05.16.492174. PMID 36194562. PMC 9531837. https://www.biorxiv.org/content/10.1101/2022.05.16.492174v1. 
    28. ↑ Furutani-Seiki, Makoto; Sasado, Takao; Morinaga, Chikako; Suwa, Hiroshi; Niwa, Katsutoshi; Yoda, Hiroki; Deguchi, Tomonori; Hirose, Yukihiro et al. (July 2004). "A systematic genome-wide screen for mutations affecting organogenesis in Medaka, Oryzias latipes" (in English). Mechanisms of Development 121 (7–8): 647–658. doi:10.1016/j.mod.2004.04.016. ISSN 0925-4773. PMID 15210174. https://research.monash.edu/en/publications/a-systematic-genome-wide-screen-for-mutations-affecting-organogen. 
    29. ↑ Miyamoto, Tatsuo; Porazinski, Sean; Wang, Huijia; Borovina, Antonia; Ciruna, Brian; Shimizu, Atsushi; Kajii, Tadashi; Kikuchi, Akira et al. (2011-05-15). "Insufficiency of BUBR1, a mitotic spindle checkpoint regulator, causes impaired ciliogenesis in vertebrates". Human Molecular Genetics 20 (10): 2058–2070. doi:10.1093/hmg/ddr090. ISSN 0964-6906. PMID 21389084. https://doi.org/10.1093/hmg/ddr090. 
    30. ↑ Brand, M.; Heisenberg, C.P.; Warga, R.M.; Pelegri, F.; Karlstrom, R.O.; Beuchle, D.; Picker, A.; Jiang, Y.J. et al. (1996-12-01). "Mutations affecting development of the midline and general body shape during zebrafish embryogenesis". Development 123 (1): 129–142. doi:10.1242/dev.123.1.129. ISSN 0950-1991. PMID 9007235. https://doi.org/10.1242/dev.123.1.129. 
    31. ↑ "Makoto Furutani-seiki - Academia.edu". https://independent.academia.edu/MakotoFurutaniseiki. 
    32. ↑ "Makoto Furutani-Seiki". http://www.nasonline.org/programs/kavli-frontiers-of-science/frontiers-alumni/alumni-directory/makoto-furutani-seiki.html. 
    33. ↑ "Regenerative Medicine Research". https://www.regenmedres-journal.org/about-the-journal/editorial-board. 
    34. ↑ 34.0 34.1 "清木 誠 (Seiki Makoto) - 米国癌学会 - 所属学協会 - researchmap". https://researchmap.jp/7000021820/association_memberships/9919554. 

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