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    SLC45A4

    Topic: Biology

     From Handwiki - Reading time: 1 min
    Short description: Protein


    A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
    Generic protein structure example

    SLC45A4 is a member of the SLC45 family of solute carriers. Analysis of the protein function in a recombinant yeast expression assay show that it can: (i) transport a disaccharide, sucrose, as well simple sugars such as glucose and fructose (ii) perform secondary active transport in a proton-dependent manner.[1]

    It is associated with sugar transport in the spermatozoa.[2] Additionally, it has been identified as a necessary component in the cell death caused of the compound paraquat.[3]

    References

    1. ↑ "Proton-associated sucrose transport of mammalian solute carrier family 45: an analysis in Saccharomyces cerevisiae". The Biochemical Journal 464 (2): 193–201. December 2014. doi:10.1042/BJ20140572. PMID 25164149. 
    2. ↑ "+/sugar cotransporter in mammalian spermatozoa". Pflügers Archiv 469 (11): 1433–1442. November 2017. doi:10.1007/s00424-017-2024-9. PMID 28689241. 
    3. ↑ "A CRISPR screen identifies a pathway required for paraquat-induced cell death". Nature Chemical Biology 13 (12): 1274–1279. December 2017. doi:10.1038/nchembio.2499. PMID 29058724. 




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