Categories
  • Nociceptin receptor agonists
  • 4-Phenylpiperidines
  • Experimental drugs
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    AT-121

    Topic: Chemistry

     From Handwiki - Reading time: 1 min
    Short description: Chemical compound
    AT-121
    AT-121.svg
    Legal status
    Legal status
    • Investigational
    Identifiers
    CAS Number
    PubChem CID
    Chemical and physical data
    FormulaC24H38N4O3S
    Molar mass462.65 g·mol−1
    3D model (JSmol)

    AT-121 is an experimental analgesic. It was designed to be bifunctional, acting as an agonist at both the μ-opioid receptor and the nociceptin receptor.[1] The interaction with the nociceptin receptor is expected to block the abuse and dependence-related side effects that are typical of opioids.[2] A study in nonhuman primates found that AT-121 has morphine-like analgesic effects, but suppressed the addictive effects.[1][3]

    See also

    References

    1. ↑ 1.0 1.1 "A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates". Science Translational Medicine 10 (456): eaar3483. August 2018. doi:10.1126/scitranslmed.aar3483. PMID 30158150. 
    2. ↑ "Scientists take big step toward finding non-addictive painkiller". Science Daily. August 29, 2018. https://www.sciencedaily.com/releases/2018/08/180829143821.htm. 
    3. ↑ "Study: Non-addictive painkiller is safe, effective in animals". UPI. August 30, 2018. https://www.upi.com/Health_News/2018/08/30/Study-Non-addictive-painkiller-is-safe-effective-in-animals/4621535636997/. 



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