Categories
  • Abandoned drugs
  • Sulfur heterocycles
  • Trifluoromethyl compounds
  • Fluoroarenes
  • Sulfones
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    CX157

    Topic: Chemistry

     From Handwiki - Reading time: 2 min
    Short description: Chemical compound
    CX157
    CX157 structure.svg
    Clinical data
    Routes of
    administration    		Oral
    ATC code
    • none
    Legal status
    Legal status
    • In general: uncontrolled
    Identifiers
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    Chemical and physical data
    FormulaC14H8F4O4S
    Molar mass348.27 g·mol−1
    3D model (JSmol)
      (verify)

    CX157 (proposed trade name TriRima, formerly Tyrima) is a selective and reversible inhibitor of MAO-A (RIMA).[1] As of 2007 it was in phase II clinical trials for the treatment of depression.[2] In 2013, work on the drug was terminated.[1]

    References

    1. ↑ "Pharmacokinetics and oral bioavailability of CX157, a reversible selective MAO-A inhibitor, in primates". 2007 AAPS Annual Meeting & Exposition. 2007. http://www.aapsj.org/abstracts/AM_2007/AAPS2007-001233.PDF. Retrieved 2009-06-14. 
    2. ↑ Clinical trial number NCT00739908} for "A Study of CX157 (TriRima) for the Treatment of Depression (CX157-200)" at ClinicalTrials.gov





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