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  • Monoclonal antibodies
  • Abandoned drugs
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    Edobacomab

    Topic: Chemistry

     From Handwiki - Reading time: 1 min
    Short description: Monoclonal antibody
    Edobacomab
    Monoclonal antibody
    TypeWhole antibody
    SourceMouse
    Targetendotoxin
    Clinical data
    Routes of
    administration    		Intravenous infusion
    ATC code
    • none
    Identifiers
    CAS Number
    ChemSpider
    • none
    UNII
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    Edobacomab, codenamed E5, is a mouse monoclonal antibody that was investigated as a possible treatment for sepsis caused by Gram-negative bacterial infections.

    Further reading

    • "A controlled clinical trial of E5 murine monoclonal IgM antibody to endotoxin in the treatment of gram-negative sepsis. The XOMA Sepsis Study Group". JAMA 266 (8): 1097–102. August 1991. doi:10.1001/jama.266.8.1097. PMID 1865542. 
    • "A second large controlled clinical study of E5, a monoclonal antibody to endotoxin: results of a prospective, multicenter, randomized, controlled trial. The E5 Sepsis Study Group". Critical Care Medicine 23 (6): 994–1006. June 1995. doi:10.1097/00003246-199506000-00003. PMID 7774238. 
    • "E5 murine monoclonal antiendotoxin antibody in gram-negative sepsis: a randomized controlled trial. E5 Study Investigators". JAMA 283 (13): 1723–30. April 2000. doi:10.1001/jama.283.13.1723. PMID 10755499. 



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