Elfazepam
Topic: Chemistry
From Handwiki - Reading time: 4 minShort description: Chemical compound
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| Formula | C19H18ClFN2O3S |
| Molar mass | 408.87 g·mol−1 |
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Elfazepam[1] is a drug which is a benzodiazepine derivative.[2] Presumably it has sedative and anxiolytic actions like those of other benzodiazepines.
Orexigenic properties in animals.[3][4] The mechanism for increasing feed intake is not clear and has been subject of investigation.[5] It has been found that elfazepam suppresses gastric acid secretion.[6]
Synthesis
Benzophenone derivative 1 is reacted with a glycine equivalent masked as an oxazolidine-2,5-dione 2 to give the final product 3 Elfazepam.
References
- ↑ U.S. Patent 4,010,154
- ↑ Psychotropics.dk
- ↑ "A review of the behavioral and physiological responses to elfazepam, a chemical feed intake stimulant". Journal of Animal Science 49 (5): 1371–95. November 1979. doi:10.2527/jas1979.4951371x. PMID 396294.
- ↑ "Endotoxin-elicited fever and anorexia and elfazepam-stimulated feeding in sheep". Physiology & Behavior 27 (2): 271–7. August 1981. doi:10.1016/0031-9384(81)90269-9. PMID 7029576.
- ↑ "Abomasal function following injections of elfazepam and 9-aza-cannabinol". Pharmacology, Biochemistry, and Behavior 10 (1): 63–70. January 1979. doi:10.1016/0091-3057(79)90170-9. PMID 35793.
- ↑ "Feeding and depression of abomasal secretion in sheep elicited by elfazepam and 9-aza-cannabinol". Pharmacology, Biochemistry, and Behavior 11 (1): 51–6. July 1979. doi:10.1016/0091-3057(79)90296-x. PMID 493298.
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Original source: https://handwiki.org/wiki/Elfazepam
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Original source: https://handwiki.org/wiki/Elfazepam
Status: article is cached
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