Flusilazole

Flusilazole
Names
	Preferred IUPAC name 1-{[Bis(4-fluorophenyl)(methyl)silyl]methyl}-1H-1,2,4-triazole
	Other names DPX-H6573;
Identifiers
CAS Number	85509-19-9 ;
3D model (JSmol)	Interactive image;
ChEBI	CHEBI:81922 ;
ChemSpider	66326 ;
PubChem CID	73675;
UNII	F3WG2VVD87 ;
	InChI InChI=1S/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3 Key: FQKUGOMFVDPBIZ-UHFFFAOYSA-N ; InChI=1/C16H15F2N3Si/c1-22(12-21-11-19-10-20-21,15-6-2-13(17)3-7-15)16-8-4-14(18)5-9-16/h2-11H,12H2,1H3 Key: FQKUGOMFVDPBIZ-UHFFFAOYAI;
	SMILES c2ncnn2C[Si](C)(c(cc1)ccc1F)c3ccc(F)cc3;
Properties
Chemical formula	C16H15F2N3Si
Molar mass	315.392 g/mol
Solubility in water	41.9 mg/L (20°C)
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

Flusilazole (DPX-H6573) is an organosilicon fungicide invented by DuPont, which is used to control fungal infections on a variety of fruit and vegetable crops.^[1]^[2]^[3] It is moderately toxic to animals and has been shown to produce birth defects in high doses.^[4]^[5]

References

↑ Moberg, W. K.; Basarab, G. S.; Cuomo, J.; Liang, P. H. (1987). "Biologically Active Organosilicon Compounds". Synthesis and Chemistry of Agrochemicals. ACS Symposium Series. 355. pp. 288–301. doi:10.1021/bk-1987-0355.ch026. ISBN 9780841214347.
↑ "Baseline toxicity of several pesticides to Hyaliodes vitripennis (Say) (Hemiptera: Miridae)". Pest Management Science 57 (11): 1007–10. November 2001. doi:10.1002/ps.374. PMID 11721516.
↑ "Effects of fungicides on in vitro spore germination and mycelial growth of the phytopathogens Leptosphaeria maculans and L. biglobosa (phoma stem canker of oilseed rape)". Pest Management Science 66 (4): 396–405. April 2010. doi:10.1002/ps.1890. PMID 20013877.
↑ "Developmental toxic effects of antifungal flusilazole administered by gavage to mice". Birth Defects Research Part B: Developmental and Reproductive Toxicology 80 (1): 12–7. February 2007. doi:10.1002/bdrb.20098. PMID 17187383.
↑ "Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies". Toxicology in Vitro 25 (3): 745–753. January 2011. doi:10.1016/j.tiv.2011.01.005. PMID 21238576.

External links

Flusilazole in the Pesticide Properties DataBase (PPDB)

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[1] Moberg, W. K.; Basarab, G. S.; Cuomo, J.; Liang, P. H. (1987). "Biologically Active Organosilicon Compounds". Synthesis and Chemistry of Agrochemicals. ACS Symposium Series. 355. pp. 288–301. doi:10.1021/bk-1987-0355.ch026. ISBN 9780841214347.

[pmid11721516-2] "Baseline toxicity of several pesticides to Hyaliodes vitripennis (Say) (Hemiptera: Miridae)". Pest Management Science 57 (11): 1007–10. November 2001. doi:10.1002/ps.374. PMID 11721516.

[pmid20013877-3] "Effects of fungicides on in vitro spore germination and mycelial growth of the phytopathogens Leptosphaeria maculans and L. biglobosa (phoma stem canker of oilseed rape)". Pest Management Science 66 (4): 396–405. April 2010. doi:10.1002/ps.1890. PMID 20013877.

[pmid17187383-4] "Developmental toxic effects of antifungal flusilazole administered by gavage to mice". Birth Defects Research Part B: Developmental and Reproductive Toxicology 80 (1): 12–7. February 2007. doi:10.1002/bdrb.20098. PMID 17187383.

[pmid21238576-5] "Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies". Toxicology in Vitro 25 (3): 745–753. January 2011. doi:10.1016/j.tiv.2011.01.005. PMID 21238576.

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Flusilazole

Topic: Chemistry

References

External links