Categories
  • Sigma agonists
  • Carboxylate esters
  • 4-Morpholinyl compounds
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    PRE-084

    Topic: Chemistry

     From Handwiki - Reading time: 3 min
    Short description: Chemical compound
    PRE-084
    PRE-084 SVG file.svg
    Clinical data
    ATC code
    • none
    Identifiers
    CAS Number
    PubChem CID
    IUPHAR/BPS
    ChemSpider
    Chemical and physical data
    FormulaC19H27NO3
    Molar mass317.429 g·mol−1
    3D model (JSmol)
     ☒N☑Y (what is this?)  (verify)

    PRE-084 is a sigma receptor agonist, selective for the σ1 subtype. It has nootropic and antidepressant actions in animal studies, as well as antitussive and reinforcing effects.[1][2][3][4][5] PRE-084 increases the expression of GDNF.[6]

    References

    1. ↑ "PRE-084, a sigma selective PCP derivative, attenuates MK-801-induced impairment of learning in mice". Pharmacology Biochemistry and Behavior 49 (4): 859–69. December 1994. doi:10.1016/0091-3057(94)90235-6. PMID 7886099. https://zenodo.org/record/1258299. 
    2. ↑ Maurice T (November 2001). "Beneficial effect of the sigma(1) receptor agonist PRE-084 against the spatial learning deficits in aged rats". European Journal of Pharmacology 431 (2): 223–7. doi:10.1016/S0014-2999(01)01436-4. PMID 11728429. 
    3. ↑ "Antitussive activity of sigma-1 receptor agonists in the guinea-pig". British Journal of Pharmacology 141 (2): 233–40. January 2004. doi:10.1038/sj.bjp.0705605. PMID 14691051. 
    4. ↑ "Antidepressant-like effect of PRE-084, a selective sigma1 receptor agonist, in Albino Swiss and C57BL/6J mice". Pharmacological Reports 61 (6): 1179–83. 2009. doi:10.1016/S1734-1140(09)70181-1. PMID 20081254. 
    5. ↑ "Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaine". The Journal of Pharmacology and Experimental Therapeutics 332 (2): 515–24. February 2010. doi:10.1124/jpet.109.159236. PMID 19892920. 
    6. ↑ "Sigma receptor agonist 2-(4-morpholinethyl)1 phenylcyclohexanecarboxylate (Pre084) increases GDNF and BiP expression and promotes neuroprotection after root avulsion injury". J. Neurotrauma 28 (5): 831–40. May 2011. doi:10.1089/neu.2010.1674. PMID 21332255. 




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