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    TachoSil

    Topic: Chemistry

     From Handwiki - Reading time: 2 min
    Short description: Collagen sponge used in surgery
    TachoSil
    Combination of
    FibrinogenGlycoprotein
    ThrombinCoagulation factor
    Clinical data
    Trade namesTachosil
    AHFS/Drugs.comProfessional Drug Facts
    License data
    Routes of
    administration    		Epilesional
    ATC code
    Legal status
    Legal status
    Identifiers
    KEGG

    Tachosil is an equine collagen sponge coated with the human plasma-derived coagulation factors fibrinogen and thrombin.[2][5] It is used during surgery to stop local bleeding on internal organs (hemostasis).[2] Tachosil reacts upon contact with blood, other body fluids or saline to form a clot that glues it to the tissue surface.[4]

    Tachosil may cause an allergic reaction, thrombosis (blood clots), a blockage in the intestine when used during abdominal surgeries, the formation of scar tissue and foreign body granuloma (a type of inflammatory reaction).[4]

    Medical uses

    Tachosil is indicated in for supportive treatment in surgery for improvement of haemostasis, to promote tissue sealing and for suture support in vascular surgery where standard techniques are insufficient.[4] Tachosil is indicated in adults for supportive sealing of the dura mater to prevent postoperative cerebrospinal leakage following neurological surgery.[4]

    References

    1. ↑ "TachoSil sealant matrix - Summary of Product Characteristics (SmPC)". 31 January 2020. https://www.medicines.org.uk/emc/product/119/smpc. 
    2. ↑ 2.0 2.1 2.2 "Tachosil- thrombin human and fibrinogen patch". 16 February 2023. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=69e05cbe-615e-45af-ad7e-92e3650cafc8. 
    3. ↑ "Tachosil- thrombin human and fibrinogen patch". 2 November 2022. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=0c324332-290f-413f-820c-8c9a971a2766. 
    4. ↑ 4.0 4.1 4.2 4.3 4.4 "TachoSil EPAR". 17 September 2018. https://www.ema.europa.eu/en/medicines/human/EPAR/tachosil.  Text was copied from this source which is copyright European Medicines Agency. Reproduction is authorized provided the source is acknowledged.
    5. ↑ "Economic and outcomes consequences of Tachosil: a systematic review". Vascular Health and Risk Management 10: 569–75. 2014. doi:10.2147/VHRM.S63199. PMID 25246797. 




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