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    Blue nevus

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    Blue nevus
    Other names: Dendritic blue nevus, common blue nevus, dermal denf=dritic melanocytotic nevus, nevus of Jadassohn, Tièche nevus, Jadassohn-Tièche nevus[1]
    Blue nevus
    SpecialtyDermatology
    SymptomsSingle well-defined blue-black bump[1]
    ComplicationsRarely malignant transformation[2]
    TypesDendritic, cellular[1]
    CausesUnclear[2]
    Diagnostic methodVisualisation, dermoscopy[3]
    Differential diagnosisDermatofibroma, melanoma[2][4]
    TreatmentMonitoring, excision[2]
    PrognosisGood[2]
    FrequencyFemale>male[5]

    A blue nevus is a type of coloured mole, typically a single well-defined blue-black bump.[1]

    The blue colour is caused by the pigment being deep in the skin.[3]

    Diagnosis is by visualisation and dermoscopy.[3] A biopsy is sometimes performed, or the whole lesion surgically removed.[2] The outcome is generally good but there is a small chance of cancerous transformation.[2] Differential diagnosis includes dermatofibroma and melanoma.[2]

    Blue nevi are more common in females than males.[5] It was first studied in 1906 by Tièche, a student of Josef Jadassohn.[6]

    Classification[edit | edit source]

    Blue nevi may be divided into the following types:[7]: 701 

    • A patch blue nevus (also known as an "acquired dermal melanocytosis", and "dermal melanocyte hamartoma") is a cutaneous condition characterized by a diffusely gray-blue area that may have superimposed darker macules.[8]
    • A blue nevus of Jadassohn–Tièche (also known as a "common blue nevus", and "nevus ceruleus") is a cutaneous condition characterized by a steel-blue papule or nodule.[7]: 701 
    • A cellular blue nevus is a cutaneous condition characterized by large, firm, blue or blue-black nodules.[7]: 701 
    • An epithelioid blue nevus is a cutaneous condition most commonly seen in patients with the Carney complex.[7]: 701 
    • A deep penetrating nevus is a type of benign melanocytic skin tumor characterized, as its name suggests, by penetration into the deep dermis and/or subcutis. Smudged chromatic is a typical finding. In some cases mitotic figures or atypical melanocytic cytology are seen, potentially mimicking a malignant melanoma. Evaluation by an expert skin pathologist is advisable in some cases to help differentiate from invasive melanoma.[7]: 701 
    • An amelanotic blue nevus (also known as a "hypomelanotic blue nevus") is a cutaneous condition characterized by mild atypia and pleomorphism.[7]: 701 
    • A malignant blue nevus is a cutaneous condition characterized by a sheet-like growth pattern, mitoses, necrosis, and cellular atypia.[8][7]: 701 

    Signs and symptoms[edit | edit source]

    It is typically a single well-defined blue-black bump.[5]

    • Blue nevus

      Blue nevus

    • Blue naevus

      Blue naevus

    • Blue naevus

      Blue naevus

    Diagnosis[edit | edit source]

    Diagnosis is by visualisation and dermoscopy.[3] A biopsy is sometimes performed.[2]

    Dermoscopy[edit | edit source]

    • Blue naevus

      Blue naevus

    • Blue nevus and dermoscopy

      Blue nevus and dermoscopy

    Histopathology[edit | edit source]

    • Micrograph of a blue nevus showing the characteristic pigmented melanocytes between bundles of collagen. H&E stain.

      Micrograph of a blue nevus showing the characteristic pigmented melanocytes between bundles of collagen. H&E stain.

    • Blue nevus

      Blue nevus

    • Cellular blue nevus

      Cellular blue nevus

    • Epithelioid blue nevus

      Epithelioid blue nevus

    • Malignant blue nevus

      Malignant blue nevus

    Epidemiology[edit | edit source]

    Various differential diagnoses of pigmented skin lesions, by relative incidence and malignancy potential, including "Blue nevus" near top.

    Blue nevi are more common in females than males.[5]

    History[edit | edit source]

    It was first studied in 1906 by Tièche, a student of Josef Jadassohn.[6]

    See also[edit | edit source]

    References[edit | edit source]

    1. ↑ 1.0 1.1 1.2 1.3 DE, Elder; D, Massi; RA, Scolyer; R, Willemze (2018). "2. Melanocytic tumours: Blue nevus and cellular blue naevus". WHO Classification of Skin Tumours. Vol. 11 (4th ed.). Lyon (France): World Health Organization. pp. 126–129. ISBN 978-92-832-2440-2. Archived from the original on 2022-07-11. Retrieved 2022-08-20.
    2. ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Austad, Steve S.; Athalye, Leela (2021). "Blue Nevus". StatPearls. StatPearls Publishing. Archived from the original on 2021-10-13. Retrieved 2021-10-12.
    3. ↑ 3.0 3.1 3.2 3.3 "Blue naevus". dermnetnz.org. Archived from the original on 13 August 2021. Retrieved 12 October 2021.
    4. ↑ Blue+Nevi at the US National Library of Medicine Medical Subject Headings (MeSH)
    5. ↑ 5.0 5.1 5.2 5.3 Johnstone, Ronald B. (2017). "32. Lentigines and melanomas". Weedon's Skin Pathology Essentials (2nd ed.). Elsevier. p. 545. ISBN 978-0-7020-6830-0. Archived from the original on 2021-05-25. Retrieved 2021-09-25.
    6. ↑ 6.0 6.1 Sreeremya, S. (17 April 2018). "Blue Nevus". International Journal of Molecular Biotechnology. 4 (1): 1–4. doi:10.37628/ijmb.v4i1.255. Archived from the original on 13 October 2021. Retrieved 12 October 2021.
    7. ↑ 7.0 7.1 7.2 7.3 7.4 7.5 7.6 James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
    8. ↑ 8.0 8.1 Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. p. 1722. ISBN 978-1-4160-2999-1.

    External links[edit | edit source]

    Classification
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