Categories
  • Cannabinoids
    •   Encyclosphere.org ENCYCLOREADER
      supported by EncyclosphereKSF

    Ajulemic acid

    From Wikidoc - Reading time: 3 min
    Ajulemic acid
    File:Ajulemicacid.png
    Identifiers
    CAS Number
    PubChem CID
    E number{{#property:P628}}
    ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
    Chemical and physical data
    FormulaC25H36O4
    Molar mass400.551 g/mol

    Ajulemic acid (IP-751) is a synthetic cannabinoid derivative of the non-psychoactive THC metabolite 11-carboxy-THC which shows useful analgesic and anti-inflammatory effects without causing a subjective "high".[1] It is being developed for the treatment of neuropathic pain and inflammatory conditions such as arthritis.[2] It does not however share the anti-emetic effects of other cannabinoids but may be useful for treating pain and chronic inflammatory conditions where nausea is not present.[3] Side effects include dry mouth, tiredness and dizziness. The mechanism of action has not yet been established, but ajulemic acid may activate the CB1 receptor in a different way to psychoactive cannabinoids. [4]

    References[edit | edit source]

    1. ↑ Burstein SH, Karst M, Schneider U, Zurier RB. Ajulemic acid: A novel cannabinoid produces analgesia without a "high". Life Sciences. 2004 Aug 6;75(12):1513-22.
    2. ↑ Mitchell VA, Aslan S, Safaei R, Vaughan CW. Effect of the cannabinoid ajulemic acid on rat models of neuropathic and inflammatory pain. Neuroscience Letters. 2005 Jul 15;382(3):231-5.
    3. ↑ Burstein S. Ajulemic acid (IP-751): synthesis, proof of principle, toxicity studies, and clinical trials. AAPS Journal. 2005 Jun 29;7(1):E143-8.
    4. ↑ Vann RE, Cook CD, Martin BR, Wiley JL. Cannabimimetic properties of ajulemic acid. Journal of Pharmacology and Experimental Therapeutics. 2007 Feb;320(2):678-86.

    it:Acido ajulemico

    This article is licensed under CC BY-SA 3.0.
    Original source: https://wikidoc.org/Ajulemic acid
    Status: article is cached
    Encyclosphere.org EncycloReader is supported by the EncyclosphereKSF