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CA6

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Carbonic anhydrase VI
Identifiers
Symbols CA6 ; GUSTIN; MGC21256
External IDs Template:OMIM5 Template:MGI HomoloGene: 20324
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Carbonic anhydrase VI, also known as CA6, is a human gene.[1]

The protein encoded by this gene is one of several isozymes of carbonic anhydrase. This protein is found only in salivary glands and saliva and protein may play a role in the reversible hydratation of carbon dioxide though its function in saliva is unknown.[1]

References[edit | edit source]

  1. ↑ 1.0 1.1 "Entrez Gene: CA6 carbonic anhydrase VI".

Further reading[edit | edit source]

  • Nishimori I, FujikawaAdachi K, Onishi S, Hollingsworth MA (1999). "Carbonic anhydrase in human pancreas: hypotheses for the pathophysiological roles of CA isozymes". Ann. N. Y. Acad. Sci. 880: 5–16. PMID 10415846.
  • Kivela J, Parkkila S, Parkkila AK; et al. (1999). "Salivary carbonic anhydrase isoenzyme VI". J. Physiol. (Lond.). 520 Pt 2: 315–20. PMID 10523402.
  • Nishimori I, Onishi S (2001). "Carbonic anhydrase isozymes in the human pancreas". Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 33 (1): 68–74. PMID 11303978.
  • Breton S (2002). "The cellular physiology of carbonic anhydrases". JOP. 2 (4 Suppl): 159–64. PMID 11875253.
  • Aldred P, Fu P, Barrett G; et al. (1991). "Human secreted carbonic anhydrase: cDNA cloning, nucleotide sequence, and hybridization histochemistry". Biochemistry. 30 (2): 569–75. PMID 1899030.
  • Parkkila S, Kaunisto K, Rajaniemi L; et al. (1990). "Immunohistochemical localization of carbonic anhydrase isoenzymes VI, II, and I in human parotid and submandibular glands". J. Histochem. Cytochem. 38 (7): 941–7. PMID 2113069.
  • Murakami H, Sly WS (1987). "Purification and characterization of human salivary carbonic anhydrase". J. Biol. Chem. 262 (3): 1382–8. PMID 2433278.
  • Sutherland GR, Baker E, Fernandez KE; et al. (1989). "The gene for human carbonic anhydrase VI(CA6) is on the tip of the short arm of chromosome 1". Cytogenet. Cell Genet. 50 (2–3): 149–50. PMID 2505973.
  • Ogawa Y, Hong SS, Toyosawa S; et al. (1993). "Immunoelectron microscopy of carbonic anhydrase isozyme VI in human submandibular gland: comparison with isozymes I and II". J. Histochem. Cytochem. 41 (3): 343–51. PMID 8429198.
  • Kivelä J, Parkkila S, Waheed A; et al. (1998). "Secretory carbonic anhydrase isoenzyme (CA VI) in human serum". Clin. Chem. 43 (12): 2318–22. PMID 9439449.
  • White PS, Jensen SJ, Rajalingam V; et al. (1998). "Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2". Cytogenet. Cell Genet. 81 (1): 60–4. PMID 9691177.
  • Thatcher BJ, Doherty AE, Orvisky E; et al. (1998). "Gustin from human parotid saliva is carbonic anhydrase VI". Biochem. Biophys. Res. Commun. 250 (3): 635–41. doi:10.1006/bbrc.1998.9356. PMID 9784398.
  • Leinonen J, Kivelä J, Parkkila S; et al. (1999). "Salivary carbonic anhydrase isoenzyme VI is located in the human enamel pellicle". Caries Res. 33 (3): 185–90. PMID 10207193.
  • Redman RS, Peagler FD, Johansson I (2000). "Immunohistochemical localization of carbonic anhydrases I, II, and VI in the developing rat sublingual and submandibular glands". Anat. Rec. 258 (3): 269–76. PMID 10705347.
  • Leinonen J, Parkkila S, Kaunisto K; et al. (2001). "Secretion of carbonic anhydrase isoenzyme VI (CA VI) from human and rat lingual serous von Ebner's glands". J. Histochem. Cytochem. 49 (5): 657–62. PMID 11304804.
  • Karhumaa P, Leinonen J, Parkkila S; et al. (2001). "The identification of secreted carbonic anhydrase VI as a constitutive glycoprotein of human and rat milk". Proc. Natl. Acad. Sci. U.S.A. 98 (20): 11604–8. doi:10.1073/pnas.121172598. PMID 11553764.

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