IgA nephropathy historical perspective

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Ali Poyan Mehr, M.D. [2] Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]

Overview[edit | edit source]

IgA nephropathy (Berger disease) was first described by Jean Berger, a pathologist, and Nicole Hinglais, an electron microscopist, in 1968 in France.

Historical Perspective[edit | edit source]

• In 1968, IgA nephropathy was first described by Jean Berger, a pathologist, and Nicole Hinglais, an electron microscopist, in France.^[1][2][3][4]

• IgA nephropathy was originally described by Berger and Hinglais in 1968. In the original one-page article titled “Les depots intercapillaires d'IgA-IgG” in the “journal d’Urologie-Nephrologie”, the authors described the renal disease under light microscopy showing focal and segmental mesangial proliferation with expansion of the matrix. Under electron microscopy, they noted the predominance of IgA deposits in the renal mesangium that were associated with the presence of less significant presence of IgG and C3.
• In 1969, following the first description of IgA nephropathy, the association of IgA nephropathy with Henoch-Schönlein purpura was described by Berger.^[1]

References[edit | edit source]

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