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NID2

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Nidogen 2 (osteonidogen)
Identifiers
Symbols NID2 ;
External IDs Template:OMIM5 Template:MGI HomoloGene: 40575
RNA expression pattern
File:PBB GE NID2 204114 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Nidogen 2 (osteonidogen), also known as NID2, is a human gene.[1]

Basement membranes, which are composed of type IV collagens (see MIM 120130), laminins (see LAMC1; MIM 150290), perlecan (HSPG2; MIM 142461), and nidogen (see NID1; MIM 131390), are thin pericellular protein matrices that control a large number of cellular activities, including adhesion, migration, differentiation, gene expression, and apoptosis.[supplied by OMIM][1]

References[edit | edit source]

  1. ↑ 1.0 1.1 "Entrez Gene: NID2 nidogen 2 (osteonidogen)".

Further reading[edit | edit source]

  • Ulazzi L, Sabbioni S, Miotto E; et al. (2007). "Nidogen 1 and 2 gene promoters are aberrantly methylated in human gastrointestinal cancer". Mol. Cancer. 6: 17. doi:10.1186/1476-4598-6-17. PMID 17328794.
  • Nischt R, Schmidt C, Mirancea N; et al. (2007). "Lack of nidogen-1 and -2 prevents basement membrane assembly in skin-organotypic coculture". J. Invest. Dermatol. 127 (3): 545–54. doi:10.1038/sj.jid.5700562. PMID 17008882.
  • Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
  • Rual JF, Venkatesan K, Hao T; et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
  • Miosge N, Sasaki T, Timpl R (2003). "Evidence of nidogen-2 compensation for nidogen-1 deficiency in transgenic mice". Matrix Biol. 21 (7): 611–21. PMID 12475645.
  • Miosge N, Holzhausen S, Zelent C; et al. (2002). "Nidogen-1 and nidogen-2 are found in basement membranes during human embryonic development". Histochem. J. 33 (9–10): 523–30. PMID 12005023.
  • Tu H, Sasaki T, Snellman A; et al. (2002). "The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin". J. Biol. Chem. 277 (25): 23092–9. doi:10.1074/jbc.M107583200. PMID 11956183.
  • Sasaki T, Göhring W, Mann K; et al. (2002). "Short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin and proteins". J. Mol. Biol. 314 (4): 751–63. doi:10.1006/jmbi.2001.5176. PMID 11733994.
  • Sasaki T, Göhring W, Miosge N; et al. (1999). "Tropoelastin binding to fibulins, nidogen-2 and other extracellular matrix proteins". FEBS Lett. 460 (2): 280–4. PMID 10544250.
  • Kohfeldt E, Sasaki T, Göhring W, Timpl R (1998). "Nidogen-2: a new basement membrane protein with diverse binding properties". J. Mol. Biol. 282 (1): 99–109. doi:10.1006/jmbi.1998.2004. PMID 9733643.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. PMID 8889548.

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