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    Pheochromocytoma risk factors

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    Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2] Ifrah Fatima, M.B.B.S[3]

    Overview[edit | edit source]

    The most potent risk factor for pheochromocytoma is a family history of multiple endocrine neoplasias, Von Hippel-Lindau disease, neurofibromatosis type 1, hereditary paraganglioma syndromes.

    Risk Factors[edit | edit source]

    The most potent risk factor in the development of pheochromocytoma is a family history of multiple endocrine neoplasias, Von Hippel-Lindau disease, neurofibromatosis type 1 or hereditary paraganglioma syndromes.

    Common Risk Factors[edit | edit source]

    Less Common Risk Factors[edit | edit source]

    • Less common risk factors in the development of pheochromocytoma include harboring the following genes:
      • SDHA
      • SDHAF2
      • TMEM127 (transmembrane protein 127)
      • MAX (myc-associated factor X)
      • FH (fumarate hydratase)
      • PDH1, PDH2 (pyruvate dehydrogenase)
      • HIF1alpha (hypoxia-inducible factor)
      • MDH2 (malate dehydrogenase)
      • KIF1Bß (kinesin family member) genes. [2]

    References[edit | edit source]

    1. ↑ Gimm O (2005). "Pheochromocytoma-associated syndromes: genes, proteins and functions of RET, VHL and SDHx". Fam Cancer. 4 (1): 17–23. doi:10.1007/s10689-004-5740-1. PMID 15883706.
    2. ↑ Jameson, J (2017). Harrison's Principles of Internal Medicine 19th Edition and Harrison's Manual of Medicine 19th Edition VAL PAK. New York: McGraw-Hill Medical. ISBN 978-1260128857.
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