Categories
  • Secondary alcohols
  • Naphthalenes
  • Nitriles
  • Selective androgen receptor modulators
  • Tropanes
    •   Encyclosphere.org ENCYCLOREADER
      supported by EncyclosphereKSF

    AC-262,536

    From Wikipedia - Reading time: 7 min
    AC-262,536
    AC-262,356.svg
    Identifiers
    IUPAC name
    • 4-[(1R,3S,5S)-3-hydroxy-8-azabicyclo[3.2.1]octan-8-yl]naphthalene-1-carbonitrile
    CAS Number
    PubChem CID
    ChemSpider
    UNII
    ChEMBL
    Chemical and physical data
    FormulaC18H18N2O
    Molar mass278.355 g·mol−1
    3D model (JSmol)
    SMILES
    • OC1C[C@@H]2CC[C@H](C1)N2c3ccc(C#N)c4ccccc34
    InChI
    • InChI=1S/C18H18N2O/c19-11-12-5-8-18(17-4-2-1-3-16(12)17)20-13-6-7-14(20)10-15(21)9-13/h1-5,8,13-15,21H,6-7,9-10H2/t13-,14+,15+
    • Key:ATKWLNSCJYLXPF-FICVDOATSA-N
      (verify)

    AC-262536 is a drug developed by Acadia Pharmaceuticals which acts as a selective androgen receptor modulator (SARM). Chemically it possesses endo-exo isomerism, with the endo form being the active form. It acts as a partial agonist for the androgen receptor with a Ki of 5nM, and no significant affinity for any other receptors tested. In animal studies it produced a maximal effect of around 66% of the anabolic action of testosterone, but only around 27% of its potency as an androgen.[1][2]

    See also[edit]

    • ACP-105
    • Enobosarm
    • JNJ-28330835
    • Ligandrol

    References[edit]

    1. ^ Cutler C, Viljanto M, Taylor P, Habershon-Butcher J, Muir T, Biddle S, Van Eenoo P (February 2021). "Equine metabolism of the selective androgen receptor modulator AC-262536 in vitro and in urine, plasma and hair following oral administration". Drug Testing and Analysis. 13 (2): 369–385. doi:10.1002/dta.2932. hdl:1854/LU-8694577. PMID 32959959. S2CID 221842707.
    2. ^ Stacchini C, Botrè F, Comunità F, de la Torre X, Dima AP, Ricci M, Mazzarino M (February 2021). "Simultaneous detection of different chemical classes of selective androgen receptor modulators in urine by liquid chromatography-mass spectrometry-based techniques". Journal of Pharmaceutical and Biomedical Analysis. 195: 113849. doi:10.1016/j.jpba.2020.113849. PMID 33383501. S2CID 229941017.
    Stub icon

    This drug article relating to the genito-urinary system is a stub. You can help Wikipedia by expanding it.

    • v
    • t
    • e
    This article is licensed under CC BY-SA 3.0.
    Original source: https://en.wikipedia.org/wiki/AC-262,536
    Status: article is cached
    Encyclosphere.org EncycloReader is supported by the EncyclosphereKSF