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    Bentracimab

    From Wikipedia - Reading time: 6 min
    "REVERSE-IT" redirects here. For the Himiko Kikuchi album, see Himiko Kikuchi.
    Bentracimab
    Monoclonal antibody
    TypeFab fragment
    SourceHuman
    TargetTicagrelor, AR-C124910XX (the active metabolite)[1]
    Clinical data
    Other namesPB2452, MEDI2452
    Routes of
    administration    		Intravenous infusion
    ATC code
    • None
    Legal status
    Legal status
    • Investigational
    Identifiers
    CAS Number
    PubChem SID
    DrugBank
    UNII
    KEGG
    Chemical and physical data
    FormulaC2095H3240N560O674S12
    Molar mass47440.93 g·mol−1

    Bentracimab is a monoclonal antibody medication which has been shown in phase one and two clinical trials to function as a reversal agent for the anti–blood clotting drug ticagrelor (which acts as a P2Y12 inhibitor and is sold under the brand name Brilinta among others).[2] It is under investigation for use in major, life-threatening bleeding in patients being treated with ticagrelor.[3][4] It is not commercially available.

    See also[edit]

    • Other reversal agents for antithrombotic drugs
      • Andexanet alfa
      • Ciraparantag
      • Vitamin K
      • Idarucizumab

    References[edit]

    1. ^ "Specialist Pharmacy Service: Bentracimab". National Health Service. 10 January 2021.
    2. ^ "EU patients enrolled in REVERSE-IT trial of bentracimab for reversal of antiplatelet effects of ticagrelor". Cardiovascular News. 2021-01-29.
    3. ^ Clinical trial number NCT04286438 for "A Phase 3, Multicenter, Open-Label, Single-Arm Study of Bentracimab (PB2452) in Ticagrelor-Treated Patients With Uncontrolled Major or Life-Threatening Bleeding or Requiring Urgent Surgery or Invasive Procedure (REVERSE-IT Trial)" at ClinicalTrials.gov
    4. ^ Makhdoum A, Dhingra NK, Kirubaharan A, Eikelboom R, Luc J, Dagher O, et al. (August 2021). "Ticagrelor use and practice patterns among Canadian cardiac surgeons". Journal of Cardiac Surgery. 36 (8): 2793–2801. doi:10.1111/jocs.15636. PMID 34028081.


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