FENDRR

FENDRR
Identifiers
Aliases	FENDRR, FOXF1-AS1, TCONS_00024240, lincFOXF1, onco-lncRNA-21, FOXF1 adjacent non-coding developmental regulatory RNA, FOXF1AS1
External IDs	OMIM: 614975; GeneCards: FENDRR; OMA:FENDRR - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	86,509,099 bp
RNA expression pattern
	Top expressed in
	right lung; ; muscle layer of sigmoid colon; ; gastric mucosa; ; epithelium of colon; ; upper lobe of left lung; ; transverse colon; ; rectum; ; urinary bladder; ; gallbladder; ; body of stomach;
	n/a
	More reference expression data
	n/a
Orthologs
	400550
	n/a
	ENSG00000268388
	n/a
	n; a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

FOXF1 adjacent non-coding developmental regulatory RNA is a long non-coding RNA that in humans is encoded by the FENDRR gene. ^[3]

Function

This gene produces a spliced long non-coding RNA transcribed bidirectionally with FOXF1 on the opposite strand. A similar gene in mouse is essential for normal development of the heart and body wall. The encoded transcript is thought to act by binding to polycomb repressive complex 2 (PRC2) and/or TrxG/MLL complexes to promote the methylation of the promoters of target genes, thus reducing their expression. It has been suggested that this transcript may play a role in the progression of gastric cancer. Alternatively spliced transcript variants have been identified.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000268388 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: FOXF1 adjacent non-coding developmental regulatory RNA". Retrieved 2016-11-10.

FENDRR

Function

References

Further reading